A5100715296- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Urinary and Genital Oncology Studies
- Extracellular vesicles in disease
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Ureteral procedures and complications
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Mass Spectrometry Techniques and Applications
- Urologic and reproductive health conditions
- Cancer Immunotherapy and Biomarkers
- Historical Studies in Science
- Genetic and Kidney Cyst Diseases
- Glutathione Transferases and Polymorphisms
- Vascular Tumors and Angiosarcomas
- Chromosomal and Genetic Variations
- Nuclear Receptors and Signaling
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Phytochemicals and Antioxidant Activities
- Vascular Malformations and Hemangiomas
Zhejiang Provincial People's Hospital
2015-2025
Hangzhou Medical College
2018-2025
Bengbu Medical College
2020
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Nanjing Medical University
2011
Sir Run Run Shaw Hospital
2005
Zhejiang University
2005
Duke University
1996
MicroRNAs (miRNAs) have been widely studied in various human cancers, including bladder cancer. Previous report revealed that miR-125a-5p is downregulated urothelial carcinomas. However, the biological function and molecular mechanism of cancer has not elucidated. Therefore, this study focused on role The expression levels were firstly tested one normal cell line four lines with qRT-PCR. relative lower was detected cells. To confirm effects ectopic behaviors cells, gain-of-function assays...
C-C chemokine receptor type 7 (CCR7) overexpression correlated with lymphatic metastasis and poor prognosis is a major obstacle to bladder cancer treatment. Recent studies have revealed that miR-199a-5p was significantly abnormal expressed in several solid tumors functioned as oncogene or tumor suppressor. This study aimed further investigate the effects of on cell mediated by CCR7 cancer.Quantitative Real Time PCR (qRT-PCR) firstly performed identified expression human samples lines....
Abstract Objective To investigate the clinical effect and safety of “Y-shaped” end-to-side ureteral anastomosis with robotic endoscopic technique in radical cystectomy (RC) urinary diversion (UD) elderly obese patients bladder cancer. Materials methods We retrospectively reviewed records 10 cancer who underwent robot-assisted laparoscopic under general anesthesia at Zhejiang Provincial People’s Hospital (Affiliated Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China, 310014) from...
This work analyzes the role of versican (VCAN) on bladder cancer (BLCA). Versican is a chondroitin sulfate proteoglycan which important for tumorigenesis and development cancer. However, expression VCAN human (BLCA) has been rarely reported.The clinical significance in BLCA determined by our bioinformatics tools. Then, we performed immunohistochemical staining (IHC) analyzed correlation between clinicopathological features.The results reveal that high mRNA level was significantly associated...
Abstract Prostate cancer (PCa) is the second leading cause of death in men America, and there are no curative options for metastatic castration-resistant prostate (mCRPC). Docetaxel (DTX) has been used as a standard chemotherapy mCRPC. However, resistance to DTX significant clinical problem half patients fail respond therapy. The TR4 nuclear receptor reported play an important role PCa progression, however, its linkage remains unclear. Here we found that was upregulated after mCRPC cells...
Cutaneous lichen amyloidosis (CLA) has been reported in some multiple endocrine neoplasia type 2A (MEN 2A) families affected by specific germline RET mutations C634F/G/R/W/Y or V804M, as a characteristic of the clinical manifestation ‘MEN with CLA’, one four variants MEN 2A, which was strictly located scapular region upper back.This study reports large south-eastern Chinese pedigree 17 individuals carrying 2A-harboring C611Y (c.1832G>A) mutation Sanger sequencing. One individual presented...
Benign uretero-ileal anastomotic stricture (UIAS) is a potentially serious complication that can arise after radical cystectomy (RC) and subsequent urinary diversion. To preserve residual renal function improve prognosis, it crucial to derive insights from experience tailor individualized treatment strategies for different patients.
Human enhancer of filamentation 1 (HEF1) is a multidomain scaffolding protein that has been thought to play an important role in the tumor progression various cancers. HEF1 expression not previously reported urinary bladder carcinoma, and little known about its prognostic significance. The aim this study was evaluate patterns carcinoma investigate analyzed by immunohistochemistry using tissue microarray. A significant relationship between sex, size, number tumors, invasion depth, lymph node...
Some studies have found that thequinone oxidoreductase 1 (NQO1) SNP609 is associated with an increased risk for several malignancies. Numerous epidemiological evaluated the association between NQO1 C609T polymorphism and of prostate cancer. However, results these been conflicting. The aim this study was to provide a more precise estimation its relationship cancer using meta-analysis.Electronic searches databases were conducted all publications on before May 2013. odds ratio (OR) 95%...
Turmeric (Curcuma longa L.), a spice and food coloring agent in preparation, contains carotenoid pigment called curcumin. Curcumin has attracted extensive research interest owing to its health benefits, ranging from neuroprotection chemoprevention antioxidation. It also exhibits anti-cancer effects due capacity inhibit cancer cell proliferation stimulate apoptosis. However, the health-promoting of curcumin are limited by poor aqueous solubility low oral bioavailability. This article presents...
The aim of this study to determine the expression MMP-28 in bladder urothelial carcinoma and analyze correlation between clinicopathological characteristics human carcinoma, its relationship with patient prognosis.A total 491 surgically resected cancer samples 80 normal tissue adjacent tumor were stained by immunohistochemistry. these was quantitated, value as a marker prognosis assessed.The urinary higher than mucosa. high level significantly correlated histology grade, lymphatic...