A5082439687- Pluripotent Stem Cells Research
- Neuroendocrine Tumor Research Advances
- Neurogenesis and neuroplasticity mechanisms
- Chemical synthesis and alkaloids
- Psychedelics and Drug Studies
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Electrochemical Analysis and Applications
- Heavy Metal Exposure and Toxicity
- Microtubule and mitosis dynamics
- Eating Disorders and Behaviors
- Phagocytosis and Immune Regulation
- Gut microbiota and health
- Congenital heart defects research
- Pancreatic function and diabetes
- Single-cell and spatial transcriptomics
- Insect and Pesticide Research
- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- Chemical Reactions and Isotopes
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Cell death mechanisms and regulation
- Developmental Biology and Gene Regulation
- Epigenetics and DNA Methylation
Friedrich-Alexander-Universität Erlangen-Nürnberg
2024-2025
Imperial College London
2024-2025
Central Institute of Mental Health
2022
Heidelberg University
2022
German Cancer Research Center
2022
University Hospital Heidelberg
2022
University of Bonn
1981-2018
Heterozygous mutations of TCF4 in humans cause Pitt–Hopkins syndrome, a neurodevelopmental disease associated with intellectual disability and brain malformations. Although most studies focus on the role neural stem cells neurons, we here set out to assess implication for oligodendroglial differentiation. We discovered that both monoallelic biallelic result diminished capacity differentiate human progenitor toward myelinating oligodendrocytes through forced expression transcription factors...
Malformations of human cortical development (MCD) can cause severe disabilities. The lack human-specific models hampers our understanding the molecular underpinnings intricate processes leading to MCD. Here, we use cerebral organoids derived from patients and genome edited-induced pluripotent stem cells address pathophysiological changes associated with a complex MCD caused by mutations in echinoderm microtubule-associated protein-like 1 (EML1) gene. EML1-deficient display ectopic neural...
The importance of the gut in regulating brain–body immune axis is becoming increasingly evident. Interestingly, brain and share many common signaling molecules, with serotonin being one most notable. In fact, primary source body. However, studying dynamics a human-specific context remains challenge. Human stem cell-derived models provide promising avenue for signal transmission well-controlled, vitro environments. this study, we report first fast-scan cyclic voltammetry (FSCV) measurements...
Generation of amyloid-β peptides (Aβs) by proteolytic cleavage the protein precursor (AβPP), especially increased production Aβ 42 /Aβ 43 over 40 , and their aggregation as oligomers plaques, represent a characteristic feature Alzheimer’s disease (AD). In familial AD (FAD), altered originates from specific mutations AβPP or presenilins 1/2 (PS1/PS2), catalytic subunits γ-secretase. sporadic AD, origin Aβs remains unknown. We hypothesize that ‘human chemical exposome’ contains products able...
Abstract Enteroendocrine cells (EECs) are specialized intestinal hormone-secreting that play critical roles in metabolic homeostasis, digestion, and gut-brain communication. They detect diverse stimuli including endocrine, immune, neuronal, microbial, dietary signals, through a complex array of receptors, ion channels, transporters, to modulate the release over 20 hormones. These molecular sensors serve as potential drug targets hormone secretion, but until recently, catalogues such human...
Symmetric and asymmetric cell divisions are conserved strategies for stem expansion the generation of more committed progeny, respectively. Here, we demonstrate that in human neural cells (NSCs), lysosomes asymmetrically inherited during mitosis. We show contain Notch receptors activation occurs acidic lysosome environment. The asymmetry correlates with expression target gene HES1 activity signaling daughter cells. Furthermore, an was also observed a organoid model brain development mitotic...
Abstract In humans, most neurons are born during embryonic development and have to persist throughout the entire lifespan of an individual. Thus, human develop elaborate survival strategies protect against accidental cell death. We set out decipher developmental adaptations resulting in neuronal resilience. demonstrate that, time course maturation, install a complex complementary anti-apoptotic signaling network. This includes i.) downregulation central proteins intrinsic apoptosis pathway...
Abstract The plant homeodomain finger protein Phf8 is a histone demethylase implicated by mutation in mice and humans neural crest defects neurodevelopmental disturbances. Considering its widespread expression cell types of the central nervous system, we set out to determine role oligodendroglial cells clarify whether are possible contributing factor Phf8‐dependent disorders. Using loss‐ gain‐of‐function approaches lines primary cultures, show that promotes proliferation rodent...
Abstract The importance of the gut in regulating brain-body-immune axis is becoming increasingly evident. Interestingly, brain and share many common signalling molecules, with serotonin being one most notable. In fact, primary source body. However, studying dynamics a human-specific context remains challenge. Human stem cell-derived models provide promising avenue for signal transmission well-controlled, vitro environments. this study, we report first fast-scan cyclic voltammetry (FSCV)...
Neuroplasticity, the ability of nervous system to adapt throughout an organism's lifespan, offers potential as both a biomarker and treatment target for neuropsychiatric conditions. Psychedelics, burgeoning category drugs, are increasingly prominent in psychiatric research, prompting inquiries into their mechanisms action. Distinguishing themselves from traditional medications, psychedelics demonstrate rapid enduring therapeutic effects after single or few administrations, believed stem...
<title>Abstract</title> Enteroendocrine cells (EECs) are specialized intestinal hormone-secreting that play critical roles in metabolic homeostasis, digestion, and gut-brain communication. They detect diverse stimuli including endocrine, immune, neuronal, microbial, dietary signals, through a complex array of receptors, ion channels, transporters, to modulate the release over 20 hormones. These molecular sensors serve as potential drug targets hormone secretion, but until recently,...