A5027012483- Estrogen and related hormone effects
- Neurological Disorders and Treatments
- Medical and Biological Sciences
- Chemical Reactions and Isotopes
- Biomarkers in Disease Mechanisms
- Diabetes and associated disorders
- Cellular transport and secretion
- Thermal Regulation in Medicine
- Pancreatic function and diabetes
- S100 Proteins and Annexins
- Wound Healing and Treatments
- Photosynthetic Processes and Mechanisms
- Mesenchymal stem cell research
- Free Radicals and Antioxidants
- Biochemical effects in animals
- Immune Response and Inflammation
- Spine and Intervertebral Disc Pathology
- Vitamin C and Antioxidants Research
- Immunotoxicology and immune responses
- Nanoparticle-Based Drug Delivery
- Heme Oxygenase-1 and Carbon Monoxide
- Spinal Cord Injury Research
- Nerve Injury and Rehabilitation
- Reproductive System and Pregnancy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Moscow State University of Medicine and Dentistry
2018-2023
Research Institute of Human Morphology
2004-2023
Ministry of Health of the Russian Federation
2020
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
2015
Agricultural Academy
2014
Pirogov Russian National Research Medical University
1994-2008
Morpho (United States)
1995
Cytestrole acetate (CA), in the structure of which steroidal antiestrogen component is associated with bis-β-cloroethylamino group, exhibits a strong cytotoxic activity against hormone-dependent cancer cell lines (CaOV, HeLa, MCF-7). In doxorubicin-resistant MCF-7 cells, CA potentiates effect etoposide and doxorubicin, IC50 for these cells 40 times lower than that tamoxifen (TAM). transplantable mice breast adenocarcinoma Ca-755, therapeutic dose 25 mg/kg when administered subcutaneously oil...
This study was aimed at the screening of a hormonal agent possessing maximum cytostatic activity with respect to cancer (MCF-7 breast cancer) cells and minimum normal (rat skin fibroblasts). The investigated substances included gestagens, androstenes antiestrogencytostatics. It is established that antiestrogencytostatics are most active cytostatics agents against MCF-7 cells. Gestagens did not produce any action upon fibroblasts. influence hormone on cell viability studied in combination...
The aim of the study is to define value sex hormone receptors expression level in serous ovarian cancer tumor cells for different variants genetic instability cellular substrate and evaluate its pathogenetic role biological "behavior" tumor. Material methods . surgical biopsy material from 89 patients with was performed histological preparations stained hematoxylin eosin by Felgen method. Subsequently, degree differentiation, mitotic regime ploidy evaluated, as well immunohistochemical...
Changes in microcirculation and impairment of microvascular wall the mesentery liver white rats under photodynamic conditions have been investigated with help biomicroscopy electron microscopy. Hematoporphyrin derivative, photosan II, photofrin chlorine E6 concentrations from 0.01 to 50 mg/kg animal body weight used as photosensitizers (PS). The total energy delivered was up 100 J/cm2. Under conditions, thrombocyte aggregation is induced, which leads periwall depositions. This process causes...
BACKGROUND: Currently, the incidence of benign ovarian tumors has increased, and numerous studies have reported its negative effect on womens reproductive health. In modern literature, approximately 30% patients with neoplasms problems. presence diseases, changes in endometrium alter receptivity, thereby reducing chances successful conception gestation gaining increasing attention. Patients seeking to preserve their function prefer organ-preserving surgical interventions; however, clinical...