A5010705806- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Nitric Oxide and Endothelin Effects
- Global Health and Surgery
- Foreign Body Medical Cases
- COVID-19 and healthcare impacts
- Tracheal and airway disorders
- SARS-CoV-2 detection and testing
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Infection Control and Ventilation
- Voice and Speech Disorders
- Anesthesia and Sedative Agents
- Global Health Workforce Issues
- Cardiac Arrest and Resuscitation
- Speech Recognition and Synthesis
- Fibroblast Growth Factor Research
- Surgical Sutures and Adhesives
- Diversity and Career in Medicine
- Respiratory Support and Mechanisms
- Cardiovascular Function and Risk Factors
- Travel-related health issues
- Venous Thromboembolism Diagnosis and Management
University of Utah
2011-2024
University of Utah Health Care
2021
Creative Commons
2021
Barro Colorado Island
2021
Yahoo (United Kingdom)
2020
Cornell University
2020
Harvard University
2016
Boston Children's Hospital
2016
University of Rwanda
2016
Non‐technical summary We investigated the role of thin fibre muscle afferents in circulatory response to exercise humans. The results not only document importance continuous afferent feedback from working human skeletal achieve appropriate haemodynamic and ventilatory responses but also suggest that relative contribution this mechanism is larger than traditionally accepted.
Passive limb movement elicits a robust increase in blood flow (LBF) and vascular conductance (LVC), but the peripheral mechanisms associated with this LBF LVC are unknown. This study sought to determine contribution of nitric oxide (NO) movement-induced document potential for passive-limb assess NO-mediated vasodilatation therefore NO bioavailability. Six subjects underwent passive knee extension without synthase (NOS) inhibition via intra-arterial infusion N(G)-monomethyl-L-arginine...
The purpose of this investigation was to partially remove feedback from type III/IV skeletal muscle afferents and determine how influences the central peripheral hemodynamic responses passive leg movement. Heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial pressure, vascular conductance (LVC), blood flow (LBF) were measured during 2 min knee extension in eight young men before after intrathecal fentanyl injection. Passive movement increased HR by 14 beats/min baseline...
The endothelin-1 vasoconstrictor pathway contributes to age-related elevations in resting peripheral vascular tone primarily through activation of the endothelin subtype A (ETA) receptor. However, regulatory influence ETA-mediated vasoconstriction during exercise elderly is unknown. Thus, 17 healthy volunteers (n = 8 young, 24±2 years; n 9 old, 70±2 years), we examined leg blood flow, mean arterial pressure, arterial–venous oxygen (O2) difference, and O2 consumption (VO2) at rest...
The cardiovascular response to exercise is governed by a combination of vasodilating and vasoconstricting influences that optimize exercising muscle perfusion while protecting mean arterial pressure (MAP). degree which endogenous endothelin (ET)-1, the body's most potent vasoconstrictor, participates in this unknown. Thus, eight young (24 ± 2 yr), healthy volunteers, we examined leg blood flow, MAP, tissue oxygenation, heart rate, arterial-venous O difference, consumption, pH, net ET-1...
Aging is characterized by increased sympatho-excitation, expressed through both the α-adrenergic and RAAS (renin-angiotensin-aldosterone) pathways. Although independent contribution of these two pathways to elevated vasoconstriction with age may be substantial, significant cross-talk exists that could produce potentiating effects. To examine this interaction, 14 subjects (n=8 young, n=6 old) underwent brachial artery catheterization for administration AngII (angiotensin II; 0.8-25.6 ng/dl...
Rwanda currently faces a severe shortage of trained medical personnel, including physician anesthesiologists. The recruitment residents into the anesthesia program has been consistently low. This study aimed at determining factors that influence undergraduates' decision to pursue as career choice.A questionnaire was created and administered final year undergraduate students University Rwanda. based on identified from literature review key informant interviews. translated, field-tested,...
The consequence of elevated oxidative stress on exercising skeletal muscle blood flow as well the transport and utilization O2 in patients with chronic obstructive pulmonary disease (COPD) is not understood. present study examined impact an oral antioxidant cocktail (AOC) leg (LBF) consumption during dynamic exercise 16 COPD healthy subjects. Subjects performed submaximal (3, 6, 9 W) single-leg knee extensor while LBF (Doppler ultrasound), mean arterial pressure, vascular conductance,...
Effective rescue after failed intubation is important to limit the number of attempts and patient risk. Nothing known about Total Control Introducer's (TCI) effectiveness as an device. A single system's airway management database was studied. The TCI used for in 34 cases. Overall success 33 (97%). First-pass 32 successful 12 (100%) video direct laryngoscopy had failed. In this case series, found be a highly effective technique laryngoscopy.
Both altered shear rate and endothelin-1 (ET-1) are associated with the age-related development of atherosclerosis. However, role ET-1, a potent endogenous vasoconstrictor, in altering humans, especially atherosclerotic-prone vasculature leg, is unknown. Therefore, this study examined contribution ET-1 to alterations common femoral artery (CFA) rate.BQ-123, specific endothelin type A (ET(A)) receptor antagonist, was infused into CFA, diameter blood velocity were measured by Doppler...
We describe the first use of an articulating Total Control Introducer (TCI) and video laryngoscope (VL) to guide intubation a patient with known difficult airway. The was 84-year-old woman Mallampati IV airway assessment, small mouth opening, limited neck extension, micrognathia. utilized VL visualize glottis TCI for endotracheal tube placement. Anteflexion retroflexion introducer tip allowed dynamic navigation through upper into trachea. Intubation performed on attempt without complications.
We would like to thank Cook et al. for their consensus guidelines managing the airway in patients with COVID-19 1. Airway management patient is a point of risk concentration providers, and medical systems. Time essence if systems are turn tide collapse seen Wuhan, Italy, Spain now, New York. highlight two points arising from our reading these guidelines. First, failure minimise aggregate poses strategic threat systems; two, it critical include mental bandwidth saturation as contamination. In...
Tracheal intubation requires solving 2 problems: visualization of the glottis and navigation an endotracheal tube into trachea. Even when is solved, around a tumor can remain problem while accessing We report successful patient with supraglottic using modified combined technique involving video laryngoscope for in combination Total Control Introducer precision tracheal access.
Background & Objectives: Induction of anesthesia is a time increased risk for surgical patients, especially in resource poor settings. Some this may be due to errors preparation, and the use checklists an effective strategy reduction. We hypothesized that performance Pre-anesthetic Patient Safety (PIPS) checklist would reduce preparation as well problems such cardiopulmonary instability. Materials Methods: A pre-checklist group was established by observing 72 non-consecutive inductions...
We investigated the role of somatosensory feedback on hemodynamic and ventilatory responses to exercise. Nine males performed knee-extensor exercise (15/30/45 W, 3-min each) with without lumbar intrathecal fentanyl (L3–L4) impairing central projection spinal μ-opioid receptor-sensitive muscle afferents. Femoral venous arterial catheterization was combined Doppler femoral blood flow measures (FBF). Pulmonary/hemodynamic variables were recorded continuously, FBF simultaneously taken during...
Introduction: Studies point to the potential advantages of a combined technique using video laryngoscopes (VL) and dynamic stylets for difficult intubations. This study compares outcomes three advanced intubation techniques: (video laryngoscope + stylet), awake fiberoptic bronchoscope (FOB), asleep FOB when used as primary technique. Methods: Airway notes 138,387 consecutive anesthesia cases at single academic medical center were filtered use FOB, or approach potentially The was defined VL...
<sec> <title>UNSTRUCTURED</title> What does the COVID-19 false-negative exposure problem mean in context of a local anesthesia practice? We present customizable online calculator designed to quantify and better understand individual aggregate provider risk. </sec>
Article| July 2022 Fail Often. Hold Fast! Sean Runnels, MD, D.ABA Search for other works by this author on: This Site PubMed Google Scholar ASA Monitor 2022, Vol. 86, 1–8. https://doi.org/10.1097/01.ASM.0000842008.60155.f4 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share MailTo Twitter LinkedIn Cite Get Permissions Citation Runnels; Fast!. 2022; 86:1–8 doi: Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers...
What does the COVID-19 false-negative exposure problem mean in context of a local anesthesia practice? We present customizable online calculator designed to quantify and better understand individual aggregate provider risk.