A5074677778- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Nutrition and Health in Aging
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Gastrointestinal motility and disorders
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Heart Failure Treatment and Management
- Diabetes and associated disorders
- Muscle metabolism and nutrition
- Lipid metabolism and disorders
- Bariatric Surgery and Outcomes
- Biochemical effects in animals
- Glycogen Storage Diseases and Myoclonus
- Dietary Effects on Health
Inserm
2019-2025
Université Claude Bernard Lyon 1
2019-2025
Nutrition, Diabète et Cerveau
2019-2024
Objective Hepatic steatosis accompanying obesity is a major health concern, since it may initiate non-alcoholic fatty liver disease (NAFLD) and associated complications like cirrhosis or cancer. Intestinal gluconeogenesis (IGN) recently described function that contributes to the metabolic benefits of specific macronutrients as protein soluble fibre, via initiation gut-brain nervous signal triggering brain-dependent regulations peripheral metabolism. Here, we investigate effects IGN on...
Atrial natriuretic peptide (ANP) is a cardiac hormone controlling blood volume and pressure in mammals. It still unclear whether ANP controls cold-induced thermogenesis vivo. Here, we show that acute cold exposure induces secretion mice humans. Genetic inactivation of promotes intolerance suppresses half brown adipose tissue (BAT) activation mice. While white adipocytes are resistant to ANP-mediated lipolysis at thermoneutral temperature mice, renders fully responsive activate thermogenic...
Abstract Objective Intestinal gluconeogenesis (IGN), via the initiation of a gut‐brain nervous circuit, accounts for metabolic benefits linked to dietary proteins or fermentable fiber in rodents and has been positively correlated with rapid amelioration body weight after gastric bypass surgery humans obesity. In particular, activation IGN moderates development hepatic steatosis accompanying this study, we investigated specific effects on adipose tissue metabolism, independent its induction...
Type 2 diabetes (T2D) and obesity are strongly associated with low natriuretic peptide (NP) plasma levels a down-regulation of NP guanylyl cyclase receptor-A (GCA) in skeletal muscle adipose tissue. However, no study has so far provided evidence for causal link between atrial (ANP)/GCA deficiency T2D pathogenesis. Here, we show that both systemic ANP/GCA deficiencies mice promote metabolic disturbances prediabetes. Skeletal insulin resistance is further altered mitochondrial function...
Thyroid hormone (T3) and its nuclear receptors (TR) are important regulators of energy expenditure adaptive thermogenesis, notably through their action in the brown adipose tissue (BAT). However, T3 acts many other peripheral central tissues which also involved expenditure. The general picture how regulates BAT thermogenesis is currently not fully established, due to absence extensive omics analyses lack specific mice model. Here, we first used transcriptome cistrome establish list T3/TR...
Abstract Intestinal gluconeogenesis (IGN), gastric bypass (GBP) and gut microbiota positively regulate glucose homeostasis diet-induced dysmetabolism. GBP modulates microbiota, whether IGN could shape it has not been investigated. We studied microbiome in wild type IGN-deficient mice, undergoing or not, fed on either a normal chow (NC) high-fat/high-sucrose (HFHS) diet. also fecal urine metabolome NC-fed mice. had different effect the of mice with NC HFHS inactivation increased abundance...
Roux-en-Y gastric surgery (RYGB) promotes a rapid and sustained weight loss amelioration of glucose control in obese patients. A high number molecular hypotheses were previously tested using duodenal-jejunal bypass (DJB) performed various genetic models mice with knockouts for hormones or receptors. The data globally negative inconsistent. Therefore, the mechanisms remained elusive. Intestinal gluconeogenesis is gut function that has been suggested to contribute metabolic benefits RYGB...
<b><i>Introduction:</i></b> Intestinal gluconeogenesis (IGN) exerts metabolic benefits in energy homeostasis via the neural sensing of portal glucose. <b><i>Objective:</i></b> The aim this work was to determine central mechanisms involved effects IGN on control homeostasis. <b><i>Methods:</i></b> We investigated glucose infusion into vein, at a rate that mimics IGN, conscious wild-type, leptin-deficient...
Protein-enriched diets improve glycemic control in diabetes or emotional behavior depressive patients. In mice, these benefits depend on intestinal gluconeogenesis activation by di-/tripeptides. Intestinal di-/tripeptides absorption is carried out the peptide transporter 1, PEPT1. The lack of PEPT1 might thus alter glucose and balance.
ABSTRACT Objective Intestinal gluconeogenesis, via the initiation of a gut-brain nervous circuit, accounts for metabolic benefits linked to dietary proteins or fermentable fibre in rodents and has been positively correlated with rapid amelioration body weight after gastric bypass surgery obese humans. In particular, activation intestinal gluconeogenesis moderates development hepatic steatosis accompanying obesity. this study, we investigated specific effects on adipose tissue metabolism,...
Abstract Atrial natriuretic peptide (ANP) is a cardiac hormone controlling blood volume and arterial pressure in mammals. It unclear whether how ANP controls cold-induced thermogenesis vivo . Here we show that acute cold exposure induces secretion mice humans. Genetic inactivation of promotes intolerance suppresses about half brown adipose tissue (BAT) activation mice. While white adipocytes are resistant to ANP-mediated lipolysis at thermoneutral temperature mice, renders fully responsive...
Abstract Thyroid hormone (T3) and its nuclear receptors (TR) are important regulators of energy expenditure adaptive thermogenesis, notably through their action in the brown adipose tissue (BAT). However, T3 acts many other peripheral central tissues which also involved expenditure. The general picture how regulates BAT thermogenesis is currently not fully established, due to absence extensive omics analyses lack specific mice model. Here, we first used transcriptome cistrome establish list...