A5102008586- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Prostate Cancer Treatment and Research
- Advanced Vision and Imaging
- Generative Adversarial Networks and Image Synthesis
- Advanced Battery Technologies Research
- Semiconductor Lasers and Optical Devices
- Advanced Photonic Communication Systems
- RNA Research and Splicing
- Optical Network Technologies
- Drilling and Well Engineering
- Oil and Gas Production Techniques
- Advancements in Battery Materials
- Urologic and reproductive health conditions
- Face recognition and analysis
- Model Reduction and Neural Networks
- Extracellular vesicles in disease
- Sarcoma Diagnosis and Treatment
- Video Analysis and Summarization
- Hippo pathway signaling and YAP/TAZ
- Fuel Cells and Related Materials
- Prostate Cancer Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Power System Optimization and Stability
National Clinical Research Center for Digestive Diseases
2024
Peking University
2020-2024
Peking University Shenzhen Hospital
2023-2024
Peking University First Hospital
2020-2024
Hong Kong University of Science and Technology
2023
University of Hong Kong - Shenzhen Hospital
2023
Nankai University
2023
Hebei University of Technology
2022
Huazhong University of Science and Technology
2016-2021
Tongji Hospital
2016-2021
Previous studies report that miR-1-3p, a member of the microRNA-1 family (miR-1), and functions as tumor suppressor in several different cancers. However, little is known regarding biological role intrinsic regulatory mechanisms miR-1-3p prostate cancer (PCa). In this study, expression levels were first examined PCa cell lines tissues by RT-qPCR bioinformatics. The vitro vivo functional effect was further. A luciferase reporter assay conducted to confirm target associations. We found...
Benign prostatic hyperplasia (BPH) occurs when there is an imbalance between the proliferation and death of prostate cells, which regulated tightly by estrogen signaling. However, role G protein-coupled receptor (GPER) in cell survival remains ambiguous. In this study, we observed that prostates with epithelial showed increased yes-associated protein 1 (YAP) expression decreased levels GPER. Blocking YAP through genetic or drug interventions led to reduced apoptosis cells. Interestingly,...
Recent studies indicate mammalian target of rapamycin (mTOR) may play an important role in PCa progression and drug resistance. Here, we investigated the effects a novel mTORC1/C2 dual inhibitor, AZD2014, on naive docetaxel (Doc)-pre-treated castration-resistant (CRPC) cells explored its therapeutic potential CRPCs. In current study, AZD2014 has greater inhibitory effect against 4EBP1 AKT phosphorylation than CRPC prevented feedback activation signalling. Importantly, suppressed cell growth...
Text-to-image generation models can create high-quality images from input prompts. However, they struggle to support the consistent of identity-preserving requirements for storytelling. Existing approaches this problem typically require extensive training in large datasets or additional modifications original model architectures. This limits their applicability across different domains and diverse diffusion configurations. In paper, we first observe inherent capability language models,...
Diffusion priors have been used for blind face restoration (BFR) by fine-tuning diffusion models (DMs) on datasets to recover low-quality images. However, the naive application of DMs presents several key limitations. (i) The prior has inferior semantic consistency (e.g., ID, structure and color.), increasing difficulty optimizing BFR model; (ii) reliance hundreds denoising iterations, preventing effective cooperation with perceptual losses, which is crucial faithful restoration. Observing...
A significant research effort is focused on exploiting the amazing capacities of pretrained diffusion models for editing images. They either finetune model, or invert image in latent space model. However, they suffer from two problems: (1) Unsatisfying results selected regions, and unexpected changes nonselected regions. (2) require careful text prompt where should include all visual objects input image. To address this, we propose improvements: Only optimizing value linear network...
Recent advances in 3D-aware generative models (3D-aware GANs) combined with Neural Radiance Fields (NeRF) have achieved impressive results. However no prior works investigate GANs for 3D consistent multiclass image-to-image 121) translation. Naively using 2D-121 translation methods suffers from unrealistic shape/identity change. To perform 121 translation, we decouple this learning process into a GAN step and step. In the first step, propose two novel techniques: new conditional architecture...
The recently identified phenomenon of double-stranded RNA (dsRNA)-mediated gene activation (RNAa) has been studied extensively, as it is present in humans, mice, and Caenorhabditis elegans, suggesting that dsRNA-mediated RNAa an evolutionarily conserved mechanism. Previous studies have shown dsP21-322 can induce tumor suppressor p21 expression several human cancer cells. Nonetheless, the role dsRNAs expression, including their target molecules associated key factors, remains poorly...
<b><i>Introduction:</i></b> Prostatic stromal tumor of uncertain malignant potential (STUMP) is a rare disease that may coexist with prostate sarcoma (PSS). We aimed to analyze the histological and clinical features STUMP. <b><i>Methods:</i></b> Twenty-three patients diagnosed STUMP from 2008 2019 were included. Clinicopathological follow-up information was collected. In subgroup analysis, we divided into pure group (<i>N</i> = 18)...
Glioblastoma downregulated RNA (GLIDR) is a newly discovered long non-coding (lncRNA) that its increased expression indicates poor prognosis of prostate cancer (PCa). However, the effect GLIDR on PCa cells not clear. Our study investigated role and molecular mechanism in cells. The results showed levels were higher samples than control. could regulate invasive potential, epithelial-to-mesenchymal transition (EMT) proliferation PC-3 LnCaP Besides, weaken inhibitory effects miR-128-3p...
Abstract Background Heterogeneous nuclear ribonucleoprotein K (HnRNPK) is a nucleic acid-binding protein that regulates diverse biological events. Pathologically, HnRNPK proteins are frequently overexpressed and clinically correlated with poor prognosis in various types of human cancers therefore pursued as attractive therapeutic targets for select patients. However, both the transcriptional regulation degradation prostate cancer remain poorly understood. Methods qRT-PCR was used to detect...
Distributed Generation (DG) can bring support to distribution system, meanwhile, it unbalancedness in power source, load and line. Traditional flow algorithms are not applicable the weakly meshed system with DGs. First, this paper present a direct algorithm based on BIBC matrix BCBV matrix. With some improvement is unbalanced system. Then sensitivity compensation method, improve three phase algorithm, make deal DGs of wind turbines, photovoltaic fuel cells, storage battery, microturbines,...
The accuracy of battery modeling plays a decisive role in the reliable operation and accurate state evaluation battery. In practical applications, most existing models do not consider hysteresis effect which is an important factor affecting model. To relieve negative effects effect, new equivalent circuit model (ECM) proposed. Specifically, open‐circuit voltage submodel considering temperature charge are developed. When two submodels combined with traditional ECM, can simulate behavior well...
Prostate cancer (PCa) poses a serious burden to men. Interferon-β (IFN-β) is implicated in cell growth. This study hence explored the regulation of IFN-β-modified human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) PCa cells. In vitro-cultured hUCMSCs were transfected with pcDNA3.1-IFN-β plasmid or IFN-β siRNA. hUCMSC-Exos extracted by ultracentrifugation and identified. cells (PC3 LNCap) treated Exos. Cellular internalization Exos was detected uptake assay. Cell...
The success of recent text-to-image diffusion models is largely due to their capacity be guided by a complex text prompt, which enables users precisely describe the desired content. However, these struggle effectively suppress generation undesired content, explicitly requested omitted from generated image in prompt. In this paper, we analyze how manipulate embeddings and remove unwanted content them. We introduce two contributions, refer as $\textit{soft-weighted regularization}$...
Recent advances in 3D-aware generative models (3D-aware GANs) combined with Neural Radiance Fields (NeRF) have achieved impressive results. However no prior works investigate GANs for 3D consistent multi-class image-to-image I2I) translation. Naively using 2D-I2I translation methods suffers from unrealistic shape/identity change. To perform I2I translation, we decouple this learning process into a GAN step and step. In the first step, propose two novel techniques: new conditional...
Due to the Multipoint-to-Point nature of uplink, upstream data transmission in a GPON system is burst-mode, and both guard time preamble are much shorter(32 bits 44 respectively).This burst-mode uplink brings many challenges for design receiver. This paper presents an improved main amplifier which fit AC-coupled optical receiver with short constant. Simulation analysis this scheme at aspect pattern dependent jitter also presented. Finally, simulation results provided show feasibility scheme.
Due to the Multipoint-to-Point nature of uplink, upstream data transmission in a GPON system is burst-mode, and both guard time preamble are short. This burst-mode uplink brings many challenges for design receiver. paper presents newly designed AC-coupled optical The receiver uses large constant high-speed reset switch. concept cumulative bit difference pattern-dependent jitter also put forwarded this paper. Finally, simulation results provided show feasibility scheme.
You have accessJournal of UrologyProstate Cancer: Advanced (including Drug Therapy) I (PD10)1 Apr 2020PD10-02 THE MTORC1/2 DUAL INHIBITOR AZD2014 WITH POTENT ANTITUMOR ACTIVITY IN DOCETAXEL SENSITIVE/RESISTANT PROSTATE CANCER VITRO Senmao Li, Shuai Hu, Wei Yu, and Jie Jin* LiSenmao Li More articles by this author , HuShuai Hu YuWei Yu Jin*Jie View All Author Informationhttps://doi.org/10.1097/JU.0000000000000844.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack...