Ultrasound elastography is an imaging procedure that can assess the biomechanical characteristics of different tissues. The aim this study was to define diagnostic value endobronchial ultrasound (EBUS) strain ratio mediastinal lymph nodes in patients with a suspicion lung cancer. values ratios were compared EBUS brightness mode (B-mode) features selected and their cytological diagnoses.This prospective, single-centre enrolled indication for biopsy staging after non-invasive workup tumour....

In spite of significant improvement after multi-modality treatment, prognosis most patients with glioblastoma remains poor. Standard clinical prognostic factors (age, gender, extent surgery and performance status) do not clearly predict long-term survival. The aim this case-control study was to evaluate immuno-histochemical genetic characteristics the tumour as additional in glioblastoma.Long-term survivor group were 40 survival longer than 30 months. Control shorter matched according...

After a favorable experience with gemcitabine at low dose in prolonged infusion combination cisplatin for advanced non-small-cell lung cancer, here, we present the results from phase II trial patients malignant pleural mesothelioma. Eligible had biopsy-proven mesothelioma, were chemo-naive, Eastern Cooperative Oncology Group performance status 0-2, normal hematopoietic liver and renal function, gave informed consent. Treatment consisted of 250 mg/m 6-h on days 1 8 75 day 2 3-week cycle four...

Small cell lung cancer (SCLC) represents approximately 13 to 18% of all cancers. It is the most aggressive among cancers, mostly presented at an advanced stage, with median survival rates 10 to12 months in patients treated standard chemotherapy and radiotherapy. In 15-20% brain metastases are present already time primary diagnosis; however, it unclear how much influences outcome disease according other metastatic localisation. The objective this analysis was evaluate SCLC by specific therapy...

Platinum-based therapy is widely used in the treatment of malignant mesothelioma (MM); however, efficacy and toxicity platinum agents vary greatly between patients. The aim our study was to evaluate influence pathway polymorphisms on outcome patients with MM.In total, 133 MM treated (n = 97) or without 36) platinum-based were genotyped for common XPD, ERCC1, GSTP1 polymorphisms, as well GSTM1 GSTT1 gene deletion. Haplotype analysis carried out assess combined effect nucleotide excision...

Osteosarcoma is the most common primary bone malignancy that occurs mostly in adolescents. Treatment protocols usually include multiagent preoperative and postoperative chemotherapy based on methotrexate, cisplatin, doxorubicin ifosfamide. Despite a favourable prognosis, there are considerable interindividual differences treatment outcome. Genetic variability of enzymes involved metabolism transport methotrexate could contribute towards observed response to chemotherapy. Our aim was evaluate...

Identification of biomarkers that could predict gemcitabine efficacy and toxicity is a key issue in the development individualized therapy. The aim our study was to evaluate influence pathway polymorphisms on treatment outcome patients with malignant mesothelioma (MM).In total, 107 MM, treated gemcitabine-platinum chemotherapy, were genotyped for 11 deoxycytidine kinase, ribonucleotide reductase M1 (RRM1), cytidine deaminase genes using KASPar assays. Binary logistic regression used selected...

Malignant pleural mesothelioma is a rare tumour with increasing frequency throughout the world. Due to long latency after exposure asbestos, restrictions in production and use of asbestos have not yet alleviated burden mesothelioma. During last decade, several trials confirmed benefit systemic treatment drugs such as doublets cisplatina gemcitabine or pemetrexed for carefully selected patients good performance status. The purpose this survey was assess impact whole national population...

Among attempts to delay development of resistance tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC) activating mutations epidermal growth factor receptor (EGFR), intercalated therapy has not been properly evaluated. In a phase II trial, 38 EGFR mutated NSCLC stage were treated 4 6 3-weekly cycles schedule gemcitabine (1250 mg/m2, days 1 and 4), cisplatin (75 day 2) erlotinib (150 mg, 5 – 15), followed by continuous as maintenance. addition...

After monotherapy with gemcitabine in low dose long infusion, promising results a variety of advanced chemoresistant tumors have been reported. In previous phase I trial on heavily pre-treated patients, maximum tolerated (MTD) 6 h infusion was 250 mg/m. The objective our I-II to test the combination 6-h and cisplatin treatment non-small cell lung cancer (NSCLC). Eligible patients were chemonaive, had locally or metastatic NSCLC, Eastern Oncology Cooperative Group performance status 0-2...

Soluble mesothelin-related peptides (SMRP) are a potential tumor marker for malignant mesothelioma. The aim of this study was to determine the differences in SMRP levels patients with mesothelioma before treatment and various responses investigate whether level could be useful evaluating response treatment. included treated at Institute Oncology Ljubljana between March 2007 December 2009. Blood samples were collected and/or determined using ELISA assay based upon combination two monoclonal...

Soluble mesothelin-related peptides (SMRP) are a potential tumor marker for malignant mesothelioma. The aim of this study was to determine the differences in SMRP levels patients with mesothelioma before treatment and various responses investigate whether level could be useful evaluating response treatment. included treated at Institute Oncology Ljubljana between March 2007 December 2009. Blood samples were collected and/or determined using ELISA assay based upon combination two monoclonal...

Fibulin-3 is a new potential biomarker for malignant mesothelioma (MM). This study evaluated the applicability of fibulin-3 plasma levels as response to treatment and its prognostic value progressive disease within 18 months. The in comparison with or addition soluble mesothelin-related peptides (SMRP) was also assessed.The included 78 MM patients treated at Institute Oncology Ljubljana between 2007 2011. samples obtained before various responses were measured enzyme-linked immunosorbent...

We present experience from a phase II randomized clinical trial, comparing standard gemcitabine as monotherapy with low-dose in long infusion doublet cisplatin at reduced dose for patients non-small cell lung cancer (NSCLC) and who are unfit platin-based chemotherapy. Eligible had microscopically confirmed NSCLC stage IIIB (wet) or IV, were chemo-naive, poor performance status presented significant comorbidity. Standard treatment gemcitabine, 1250 mg/m 20-30 min on days 1 8 (arm A) was...

Abstract Background Asbestos exposure has been proposed as a risk factor for shorter telomere length. The aim of our study was to investigate whether length in leukocytes and hTERT genetic polymorphisms may serve potential biomarkers the developing asbestos-related diseases progression chemotherapy response rate malignant mesothelioma (MM). Subjects methods We conducted two retrospective studies. In first study, case-control were determined patients with MM, subjects pleural plaques controls...

Is there any progress in routine management of lung cancer patients? A comparative analysis an institution 1996 and 2006Background. The aim the study was to establish eventual patients over a ten-year period at University Clinic for Respiratory Allergic Diseases Golnik, Slovenia, comparing results 345 patients, diagnosed (with performed 2002), 405 2006 2008).Patients methods. both analysed groups were comparable age number stage I II, but relatively more females, with better performance...

3T MRI in evaluation of asbestos-related thoracic diseases - preliminary resultsDisclosure No potential conflicts interest were disclosed. Background. high-field magnetic resonance imaging (MRI) scanners have recently become available for the clinical use and are being increasingly applied field whole-body chest as well. The aim this study was to evaluate diagnostic 3 T a complementary modality CT detecting pathological changes diseases.Patients methods. Fifteen patients with disease...

Background. Survivin is an inhibitor of apoptosis protein involved in the regulation cell proliferation that could be used as a marker for cancer diagnosis or prognosis. Our aim was to evaluate whether serum survivin levels influence outcome cisplatin-based chemotherapy patients with malignant mesothelioma (MM). Methods. Serum were determined using human enzyme-linked immunosorbent assay 78 MM before chemotherapy, after and at disease progression. The on tumor response survival evaluated...

A combination of pemetrexed and cisplatin has been shown to improve the outcome in patients with malignant pleural mesothelioma (MPM), however, there is a great heterogeneity treatment response among patients. The aim our study was evaluate influence polymorphisms folate pathway transporter genes on Slovenian MPM.MPM treated course prospective randomized clinical trial were genotyped for nineteen five six genes. Logistic regression used assess efficacy toxicity, while Cox determine their...

Aim: We evaluated the influence of genetic variability in translesion polymerases REV1 and REV3L on outcome cisplatin treatment malignant mesothelioma patients. Materials & methods: In total, 139 patients were genotyped for seven tag SNPs REV3L. Logistic regression Cox used to assess outcome. Results: Polymorphic rs3087403 allele TGT haplotype associated with increased risk leukopenia (p = 0.013 p 0.047, respectively) neutropenia 0.048 0.024, respectively). rs465646, rs462779 CCGG...