A5101500349- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Bacillus and Francisella bacterial research
- Carbon and Quantum Dots Applications
- Genomics and Phylogenetic Studies
- Sperm and Testicular Function
- Bacterial biofilms and quorum sensing
- Clostridium difficile and Clostridium perfringens research
- Burn Injury Management and Outcomes
- Enzyme Production and Characterization
- Aquaculture disease management and microbiota
- Antimicrobial agents and applications
- Escherichia coli research studies
- Nanoparticles: synthesis and applications
- Polyomavirus and related diseases
- Ovarian cancer diagnosis and treatment
- Insect and Pesticide Research
- Endometriosis Research and Treatment
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Nanocluster Synthesis and Applications
- Reproductive Health and Technologies
- Crop Yield and Soil Fertility
- Bioenergy crop production and management
- Microplastics and Plastic Pollution
Panjab University
2008-2024
Klebsiella pneumoniae causes infections in humans especially immunocompromised patients. About 80 % of nosocomial caused by K. are due to multidrug-resistant strains. The emergence antibiotic-resistant bacterial strains necessitates the exploration alternative antibacterial therapies, which led our group study ability viruses (known as bacteriophages or simply phages) treat mice challenged with pneumoniae. Phage SS specific for B5055 was isolated and characterized, its potential a...
This study was planned to evaluate the efficacy of silver nitrate and gentamicin in treatment burn wound infection compare it with phage therapy using an isolated well-characterized Klebsiella-specific phage, Kpn5. A full-thickness induced mice infected Klebsiella pneumoniae B5055 via topical route. Different concentrations or were applied topically daily after establishment infection. Phage Kpn5 mixed hydrogel also at m.o.i. 200 on site. The these antimicrobial agents assessed basis...
Burn wound infection remains the principal cause of death in burn patients. Efficacy honey and aloe vera gel was evaluated treatment induced with Klebsiella pneumoniae B5055 their efficacy compared an isolated well-characterized specific phage Kpn5.A full thickness mice infected K. via topical route. The natural antimicrobial agents (honey gel) topically applied daily Kpn5 suspended hydrogel a single time on wound. these assessed basis percentage that survived following treatment.In...
Hospital-acquired infections (HAIs) pose a significant risk to global health, impacting millions of individuals globally. These have increased rates morbidity and mortality due the prevalence widespread antimicrobial resistance (AMR). Graphene-based nanoparticles (GBNs) are known possess extensive properties by inflicting damage cell membrane, suppressing virulence, inhibiting microbial biofilms. Developing alternative therapies for HAIs addressing AMR can be made easier more affordable...
Maize is an economically important cereal crop, whose adaptability to a variety of agroecological zones and uses as food, feed, input in various industries has ensured its global importance. In this study, the implications raised bed planting (RBP) system on smallholder maize farming Bihar, India, for four consecutive Rabi seasons were evaluated from 2020–2021 2023–2024. The research focuses key parameters such productivity, profitability, water use efficiency (WUE), nutrient (NUE) present...
Context: Gynecological disorders represent a complex set of malignancies that result from diverse array molecular changes affecting the lives over million women worldwide. Ovarian, Endometrial, and Cervical cancers, Endometriosis, PCOS are most prevalent ones pose grave threat to women's health. Proteomics has emerged as an invaluable tool for developing novel biomarkers, screening methods, targeted therapeutic agents gynecological disorders. Some these biomarkers have been approved by FDA,...
The purpose of this study was to isolate and characterize Pseudomonas aeruginosa phages with regard their morphology, growth characteristics, genetic material structural protein composition.Five specific P. PAO were isolated from sewage samples.Adsorption rates one step curves these determined on basis, found be distinct entities.DNA all the subjected restriction enzyme digestion, confirmed presence double stranded (ds) DNA as well heterogeneity among phages.RAPD PCR analysis phage also...
Therapeutic potential of five purified and well characterized bacteriophages (Pa29, Pa30, Pa31, Pa33 Pa34) was evaluated in thermally injured Pseudomonas aeruginosa PAO infected mice.Efficacy P. phages assessed on the basis percentage survival phage treated mice.Toxicity evaluation all phages, showed them to be non toxic as no sign morbidity mortality observed mice.Survival stability specific mice maximum count various organs obtained at 3 h which persisted till 24 could detected 36 post...
The present study aims to investigate the antigenic cross reactivity between receptor from Proteus mirabilis and spermatozoa against a common sperm immobilization factor, SIF, by calorimetric competitive inhibition studies, immunogenicity of this evoke formation antisperm antibodies their subsequent role in fertility outcome. binding (PM-SBR) was extracted ultrasonicated cell debris treating it for 12 h at 37°C with 1 M NaCl. After being purified gel permeation chromatography, its molecular...
Context Sperm immobilization factor (SIF) isolated from Staphylococcus aureus has been implicated earlier in the laboratory infertility due to its negative impact on sperm function. Moreover, SIF was found bind not only human and mouse spermatozoa but also several bacteria. Among array of bacteria, we selected Shigella flexneri investigate if it shares antigenic determinants with spermatozoa. Aim The study aimed delineate receptors S. that imitate receptor binding SIF, assess therapeutic...
In the present study a number of bacterial cultures were isolated from environmental soil samples. For this, motor repairs shops are one possible site interest chosen. Isolated further screened for biosurfactant production by using oil displacement method and surface tension measurement. Minimum reduction value was found 40 dynes/ cm as compared to control (Nutrient broth) 56 dynes/cm. Selected strain also showed β-hemolysis while negative result in Cetyltrimethylammonium bromide (CTAB)...
Enzymatic degradation of peptidoglycan, a structural cell wall component Gram-positive bacteria, has attracted considerable attention being specific target for many known antibiotics.Peptidoglycan hydrolases are involved in bacterial lysis through peptidoglycan degradation. β-N-acetyl-glucosaminidase, hydrolase, acts on O-glycosidic bonds formed by N-acetylglucosamine and N-acetyl muramic acid residues peptidoglycan. Aim present study was to the action β-N-acetylglucosaminidase,...