A5007078699- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Nanowire Synthesis and Applications
- Cancer Genomics and Diagnostics
- Mathematical Biology Tumor Growth
- Advanced Biosensing Techniques and Applications
- Acute Myeloid Leukemia Research
- Gastrointestinal motility and disorders
- Pregnancy and preeclampsia studies
- Statistical Methods in Clinical Trials
- Protein purification and stability
- Reproductive System and Pregnancy
- Scheduling and Timetabling Solutions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Gastroesophageal reflux and treatments
- Pregnancy and Medication Impact
- Evolution and Genetic Dynamics
- Pharmaceutical studies and practices
University of North Carolina at Chapel Hill
2022-2025
Effector T cells need to form immunological synapses (IS) with recognized target elicit cytolytic effects. Facilitating IS formation is the principal pharmacological action of most cell-based cancer immunotherapies. However, dynamics at cell population level, primary driver pharmacodynamics many immunotherapies, remains poorly defined. Using classic immunotherapy CD3/CD19 bispecific engager (BiTE) as our model system, we integrate experimental and theoretical approaches investigate their...
Therapeutic antibodies are often prescribed off-label to pregnant patients treat inflammatory, autoimmune, or malignant conditions. Despite their broad use, the extent of fetal exposure such therapeutic and risk development remain largely unknown. Given ethical challenges conduct randomized trials in patients, modeling simulation approaches offer an opportunity yield mechanistic insights using data from observational studies. In this study, a physiologically based pharmacokinetic (PBPK)...
Abstract Busulfan is an alkylating agent used as part of conditioning chemotherapy regimens prior to allogeneic hematopoietic cell transplant (allo‐HCT). Pharmacokinetic (PK)‐guided test‐dose strategies have been shown improve the number patients achieving busulfan exposure goals and clinical outcomes. However, current practices require extensive PK sampling. In this study, data were retrospectively collected from drug monitoring records adult allo‐HCT recipients who received once‐daily...
Pediatric obesity is a growing health concern, affecting millions of children worldwide. While pharmacokinetic (PK) changes in numerous commonly prescribed medications have been linked to obesity, the physiological mechanisms driving these alterations and their implications for drug dosing remain poorly understood. The objective this study was evaluate previously reported observations reduced pantoprazole clearance (CL) with investigate obesity-related characteristics liver physiology as...
Abstract Effector T cells form immunological synapses (IS) with recognized target to elicit cytolytic effects. Facilitating IS formation is the principal pharmacological action of most cell-based cancer immunotherapies. However, dynamics at cell population level, primary driver pharmacodynamics many immunotherapies, remains poorly defined. With classic immunotherapy CD3/CD19 bispecific engager (BiTE) as a model system, we integrate experimental and theoretical approaches investigate their...