A5047928497- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Mental Health and Patient Involvement
- Health Policy Implementation Science
- Analytic Number Theory Research
- Advanced Mathematical Identities
- Historical Economic and Social Studies
- Adolescent and Pediatric Healthcare
- Cardiac Imaging and Diagnostics
- Chronic Disease Management Strategies
- Historical Studies on Spain
- Hospital Admissions and Outcomes
- Healthcare innovation and challenges
- Religion and Society Interactions
- Limits and Structures in Graph Theory
- Family Caregiving in Mental Illness
- Reformation and Early Modern Christianity
- Obesity, Physical Activity, Diet
- Advanced Neuroimaging Techniques and Applications
- Homelessness and Social Issues
- Cardiomyopathy and Myosin Studies
- Historical Studies of British Isles
- Historical Economic and Legal Thought
Manchester Academic Health Science Centre
2022-2023
University of Manchester
2022-2023
University College London
2023
Mind
2022
St Bartholomew's Hospital
2006-2016
Barts Health NHS Trust
2009-2016
Cardiff University
2016
Queen Mary University of London
2008-2015
William Harvey Research Institute
2014
St Mary's Hospital
2014
Restoring sinus rhythm in patients with heart failure (HF) and atrial fibrillation (AF) may improve left ventricular (LV) function HF symptoms. We sought to compare the effect of a catheter ablation strategy that medical rate control persistent AF HF.Patients AF, symptomatic HF, LV ejection fraction <50% were randomized or control. The primary end-point was difference between groups at 6 months. Baseline 32±8% group 34±12% group. Twenty-six underwent ablation, 24 controlled. Freedom from...
<h3>Objective</h3> To investigate whether catheter ablation of atrial fibrillation (AF) reduces stroke rate or mortality. <h3>Methods</h3> An international multicentre registry was compiled from seven centres in the UK and Australia for consecutive patients undergoing AF. Long-term outcomes were compared with (1) a cohort AF treated medically Euro Heart Survey, (2) hypothetical without AF, age gender matched to general population. Analysis death carried out after first procedure (including...
A detailed appreciation of the left atrial/pulmonary venous (LA/PV) anatomy may be important in improving safety and success catheter ablation for AF. The aim this randomized study was to determine impact computed tomographic (CT) integration into an electroanatomic mapping (EAM) system on clinical outcome patients undergoing atrial fibrillation (AF).Eighty with AF were undergo first-time wide encirclement ipsilateral PV pairs using EAM alone (40 patients) or CT patients, Cartomerge). Wide...
Catheter ablation of paroxysmal AF using the Cryoballoon (CRYO) has yielded similar success rates to conventional wide encirclement radiofrequency catheter (RFCA), but randomized data are lacking. Pilot suggested a high rate with combined approach (COMBINED) RFCA followed by 2 CRYO applications each vein. We compared these 3 strategies in controlled trial.Patients undergoing first time were RFCA, CRYO, or COMBINED. Patients up at 3, 6, and 12 months 7 days ambulatory ECG monitoring. Success...
Whether ablation of complex fractionated atrial electrograms (CFAE) modifies fibrillation (AF) by eliminating drivers or debulking remains unknown. This randomized study aimed to determine the effect ablating different CFAE morphologies compared with normal (ie, tissue) on cycle length persistent AF (AFCL).After pulmonary vein isolation left and right were targeted, until termination abolition before DC cardioversion. Ten-second classified according a validated scale, grade 1 being most 5...
Introduction: The complex anatomy of the left atrium (LA) makes location ablation catheters difficult using fluoroscopy alone, and therefore 3D mapping systems are now routinely used. We describe integration a CT image into EnSite NavX System with Fusion its validation in patients undergoing atrial fibrillation (AF) or tachycardia (AT) catheter ablation. Methods Results: Twenty‐three (61 ± 9.2 years, 16 male) paroxysmal (14) persistent (8) AF (1) AT underwent system Dynamic Registration...
<h3>Objectives</h3> To investigate long-term efficacy of catheter ablation for atrial fibrillation (AF) and the impact ablating complex or fractionated electrograms (CFEs) in addition to pulmonary vein isolation linear lesions persistent AF (PeAF). <h3>Methods</h3> Consecutive cases from 2002–2007 were analysed. All patients underwent a wide-area circumferential with confirmation electrical isolation. For PeAF, added, additional targeting CFE 2005. Data collected prospective database....
To investigate the impact of variant pulmonary vein (PV) anatomy and use three-dimensional image integration (3D-II) on long-term efficacy catheter ablation for atrial fibrillation (AF). Consecutive procedures from 2002 to 2007 were analysed a prospective database. All patients underwent wide area circumferential ablation, with linear lesions added complex fractionated electrograms targeted persistent AF. Imaging was segmented Carto assess PV anatomy. Three hundred fifty 1.9 ± 0.9...
The measurement of the absolute rate cerebral metabolic oxygen consumption (CMRO2) is likely to offer a valuable biomarker in many brain diseases and could prove be important our understanding neural function. As such there significant interest developing robust MRI techniques that can quantify CMRO2 non-invasively. One potential method for via combination fMRI blood flow (CBF) data acquired during periods hypercapnic hyperoxic challenges. This based on two, previously independent, signal...
Catheter positioning and stability are recognized challenges in catheter ablation of atrial fibrillation (AF). This prospective randomized study assessed whether routinely using a steerable sheath affects procedure outcomes.Fifty-six AF patients were to either an Agilis NXT (St Jude Medical, St Paul, MN, USA) or fixed-curve Mullins (Cook Medical Inc., Bloomington, IN, for the catheter. A mapping system with CT integration was used isolate pulmonary veins (PVs) pairs further performed if...
Integration of a 3D reconstruction the left atrium into cardiac mapping systems can aid catheter ablation atrial fibrillation (AF). The two most widely used are NavX Fusion and Cartomerge. We aimed to compare clinical efficacy these in randomised trial.Patients undergoing their first were using either fusion or CartoMerge. Pulmonary vein isolation by wide area circumferential was performed for paroxysmal AF with additional linear fractionated potential persistent AF. Seven-day Holter...
<h3>Introduction</h3> Supraventricular tachycardias (SVTs) are a common cause of acute hospital presentations. Adenosine is an effective treatment. To date, no studies have directly compared paramedic-with hospital-delivered treatment SVT with adenosine. <h3>Method</h3> Randomised controlled trial comparing the and discharge by paramedics conventional emergency department (ED)-based care. Patients were excluded if they had structural heart disease or contraindication to Discharge time,...
Background: Robotic catheter ablation aims to improve outcomes after of atrial fibrillation (AF) through improved lesion quality. This study examined electrogram attenuation as a measure efficacy in response robotic (ROB) and manual (MAN) ablation. Methods: Patients with paroxysmal AF undergoing part an ongoing randomized controlled trial were studied (Clinical Trials Registration NCT01037296). underwent pulmonary vein isolation using NavX (St. Jude Medical, St. Paul, MN, USA). MAN or ROB...
<h3>Introduction</h3> Published long term follow-up data for catheter ablation (CA) of AF is scarce. Although many centres perform complex fractionated electrograms (CFE) in addition to pulmonary vein isolation (PVI), evidence this conflicting. We sought investigate efficacy CA and the impact ablating CFE PVI linear lesions persistent (PeAF). <h3>Methods</h3> Consecutive cases from 2002 2007 at St Bartholomew9s Hospital were analysed. All patients underwent wide area circumferential with...
To compare the use of a minimal (MIN) with conventional (CON) catheter approach for mapping and ablation regular supraventricular tachycardias (SVT) typical atrial flutter (AFL) in setting randomized-controlled trial. Two hundred patients (age 51.2 ± 15.9 years, 99 male) were randomized to MIN or CON group. The involved using two catheters AFL, one three other SVT (ablation included), whereas five catheters, respectively. Acute procedural success was similar between groups. There no...
Objective To explore emergent values for community-based peer support in three projects and use of research methodology.Background Peer refers to the people with shared lived experiences provide each other. Its roots are civil rights movement, providing alternatives clinical treatments. This method is delivered different settings, varying degrees structure. In this paper, it includes experience mental health issues.Methods We reviewed interview data from two evaluations one development...
<b>Objective:</b> To see if strategy of ablating the tricuspid annulus–inferior vena cava isthmus (TV–IVC) is superior to electrical cardioversion prevent recurrences in patients with coarse atrial fibrillation. <b>Design:</b> Prospective randomised controlled multicentre study. <b>Setting:</b> Four tertiary referral hospitals UK. <b>Patients:</b> 57 persistent fibrillation (irregular P waves ⩾0.15 mV ⩾1 ECG lead). <b>Interventions:</b> Patients were receive external (group A, n = 30) or...