Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, Camargo PM. Platelet‐rich fibrin and bovine porous bone mineral vs. platelet‐rich in the treatment of intrabony periodontal defects. J Periodont Res 2012; 47: 409–417. © 2011 John Wiley & Sons A/S Background Objective: Bovine (BPBM) is a xenograft that has been successfully utilized regeneration. (PRF) leukocyte platelet preparation concentrates various polypeptide growth factors therefore potential to be used as...

Background: It has been shown that clinical improvement of intrabony periodontal defects can be achieved with the use enamel matrix proteins (EMPs) or by grafting bovine porous bone mineral (BPBM). There is no report on potential synergistic effect EMPs and BPBM in regenerative therapy. The purpose this study was to compare effectiveness used alone combination treatment humans. Methods: Twenty‐one paired were surgically treated using a split‐mouth design. Intrabony either (EMP group)...

Abstract Objective: A combination of platelet‐rich plasma (PRP), bovine porous bone mineral (BPBM) and guided tissue regeneration (GTR) has been shown to be effective as regenerative treatment for intrabony periodontal defects. The purpose this study was evaluate the effectiveness PRP, BPBM GTR used in grade II molar furcation defects humans. Material methods: Using a split‐mouth design, total 52 mandibular were treated either with PRP/BPBM/GTR (experimental group, n =26) or an open flap...

Background and objective One of the major pathologic patterns in periodontitis represents an imbalance among production free radicals local antioxidants resulting periodontal tissue destruction. The study was to investigate influence non‐surgical treatment on salivary evaluate their capacity as biomarkers reflecting condition therapy outcome. Material Methods Sixty‐three systemically healthy non‐smokers, including 21 periodontally subjects ( HC ) 42 patients with current chronic fulfilled...

Periodontitis is considered to be a risk factor for preterm birth. Mechanisms have been proposed this pathologic relation, but the exact pattern remains unclear. Therefore, objective of present study evaluate levels four major labor triggers, prostaglandin E2 (PGE2), interleukin (IL)-1β, IL-6, and tumor necrosis (TNF)-α, in gingival crevicular fluid (GCF) serum samples between women with birth (PTB) full-term (FTB) correlate them periodontal parameters.PGE2, IL-1β, TNF-α were estimated using...

Introduction. Peri-implantitis is an inflammatory lesion of peri-implant tissues. Eradication the causative bacteria and decontamination implant surface essential in achieving predictable stabile clinical results. Photodynamic therapy (PDT) non-invasive adjuvant therapeutic method to surgery treatment bacterial infection. Objective. The aim this study was evaluate early microbiological outcomes periimplantitis after surgical with PDT. Methods. Fifty-two diagnosed peri-implantitis sites were...

Background: Acute mesenteric ishemia(AMI) is a rare but very serious disease with high rate of mortality and morbidity. About 1-2% all gastrointestinal AMI. Mortality about 60-80% depends time between starting symptoms establishing diagnosis, type AMI, comorbidities. AMI often in older population coronary syndrom atrial fibrilation. may be occlusive(embolisatio arteriae mesentericae superior(AMS), or thrombosis AMS, mesenterial vein thrombosis) nonoclusive form(NOMI). NOMI rising critical...

Abstract Objectives The study aimed to investigate the effect of surgical technique, implant macrodesign and insertion torque on bone temperature changes during placement. Material methods In in vitro study, 144 self‐tapping (blue SKY ® 4 × 10 mm; B redent) non‐self‐tapping ( S tandard 4.1 traumann) were placed osteotomies prepared pig ribs by lateral condensing or drilling techniques. maximum values 30, 35 40 Ncm used. Real‐time measurement placement was performed three thermocouples...

Background and Objective Gingival recession is defined as soft hard tissue displacement resulting in root surface exposure. The optimal outcome of gingival treatment complete, predictable long‐lasting coverage with a significant level regeneration. Tissue engineering, which applies active regeneration principles, presents the contemporary approach restitution lost tissues. objective present study was to evaluate compare clinical results application an autologous fibroblast cell culture (...

Abstract Objective To assess the clinical efficacy and esthetic outcome of porcine‐derived dermal collagen matrix in comparison with connective tissue graft treatment multiple adjacent gingival recessions (MAGR), 6 12 months after surgery. Materials methods Twenty patients bilateral type I MAGR were treated randomly (test site) or (control combination a modified coronally advanced tunnel technique. The primary objectives to evaluate mean complete root coverage. secondary keratinized width,...

Introduction. Fibrin, fibronectin, platelet derived growth factor, and transforming factors from concetrate are crucial for tissue reparation regeneration. Objective. This study was designed to evaluate clinical effectiveness of activated platelet-rich fibrin (PRF) membrane in treatment gingival recession. Methods. 19 recessions Miller class I or II were treated with a coronally advanced flap the PRF (PRF group). Following elevation flap, bone root surfaces covered membrane. After suturing,...

Abstract Background: The purpose of this study was to estimate the prevalence different genotypes human cytomegalovirus (HCMV) and Epstein‐Barr virus (EBV) in peri‐implantitis mucositis sites, evaluate correlation between herpesvirus presence clinical parameters. Methods: A total 80 dental implants (mean time loading, 4.16 ± 1.8 years) were evaluated during course (30 peri‐implantitis, 25 healthy peri‐implant sites). following parameters assessed: visible plaque index, bleeding on probing,...

The aim of this study was to compare the use periodontal probing and cone beam computed tomography (CBCT) images in diagnosis furcation involvement (FI) patients with chronic generalized severe periodontitis.Fifteen periodontitis were included study. In total, 174 sites (all molar teeth) analyzed. FI assessed at three (buccal, mesiopalatal, distopalatal) maxillary molars, two (buccal oral) mandibular molars. both clinically (periodontal probing) on CBCT images, using a dichotomous scale...

Introduction/Objective. The objective of the study was to investigate whether there are differences in therapeutic effect between initial treatments chronic periodontitis [scaling and root planning (SRP)] alone SRP conjunction with injectable platelet-rich fibrin (I-PRF) application, comparing clinical parameters after three months. Methods. Twenty-four patients who had at least two sites probing pocket depth (PPD) ? 5 mm on contralateral side participated study. Using a split-mouth design,...

Notch signaling pathway, known to influence bone resorption in several oral diseases, has not been analyzed peri-implantitis yet. Therefore, the aims of present study were determine levels cascade, remodeling mediators, and pro-inflammatory cytokines, conjunction with clinical parameters, subjects peri-implant mucositis peri-implantitis.Clinical parameters: probing depth, bleeding on probing, suppuration plaque index (PI) recorded. Samples collected from 130 participants, divided into (PI),...

Abstract Background The exact mechanisms of bone resorption in periodontitis have not been fully elucidated. aims this study were to analyze the expression Notch signaling molecules, remodeling mediators, and pro‐inflammatory cytokines patients determine their potential correlations. Methods included 130 individuals: 40 with aggressive (AP group), chronic (CP 50 periodontally healthy controls. Total RNA was extracted from gingival crevicular fluid samples relative gene investigated molecules...

Abstract Background The data on polyetheretherketone (PEEK) influence the peri-implant soft tissues in clinical settings are deficient. aims of this pilot study were to analyze and compare tissues’ response PEEK titanium (Ti) healing abutments (HA) by means histological immunohistochemical analyses. Methods A total 22 implants with or Ti HA placed 11 patients, applying “split-mouth” design. Three months later, tissue specimens harvested from 20 for histology order qualitatively detect...

Peri-implantitis presents inflammatory process that affects soft and hard supporting tissues of osseointegrated implant based on osteoclastogenesis. The aim this study was to investigate whether receptor activator nuclear factor kappa B (RANK) concentrations in peri-implant crevicular fluid could be associated with clinical parameters reflect nature peri-implantitis.The included 67 patients, 22 diagnosed peri-implantitis, persons healthy 23 patients periodontitis. Clinical from each patient...

Abstract Background & Objective Notch signaling pathway has been linked to bone loss in periodontitis and peri‐implantitis. This research aimed determine the molecules expression levels (Notch1, Notch2, Jagged1, Hes1, Hey1), along with remodeling mediators (RANKL OPG) proinflammatory cytokines (TNF‐α, IL‐17, IL‐1β, IL‐6) patients peri‐implant diseases. The aforementioned markers' was evaluated different RANKL/OPG ratios. Methods Fifty peri‐implantitis (PI group) 45 mucositis (PM were...

There are very few data about the effects of endogenous growth factors in vital pulp therapy, and still they often controversial. The aim study was to evaluate platelet rich plasma (PRP) conjugation with hydroxyapatite (HAP), as capping materials, root periodontium formation.Eight young monkeys (Cercopithecus Aethiops) permanent dentition incomplete formation were involved this study. After pulpotomy, lesion capped calcium hydroxide (control), (experimental group I) or PRP II). Six months...

Aims: Bone structure around basal implants shows a dual healing mode: direct contact areas manifest primary osteonal remodeling, in the void osteotomy-induced spaces, repair begins with woven bone formation. This is later converted into bone. The purpose of this study was to develop model accurately represent interface between and implant throughout process. applied biological scenario changing load distribution system over time. Methods: Computations were made through finite element...