A5034673378- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Salmonella and Campylobacter epidemiology
- Vector-Borne Animal Diseases
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Microbial infections and disease research
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Aquaculture disease management and microbiota
- Mosquito-borne diseases and control
- Corneal Surgery and Treatments
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- T-cell and B-cell Immunology
Jeonbuk National University
2016-2025
Stanford University
2008
VA Palo Alto Health Care System
2008
University of Tennessee at Knoxville
2004-2007
University of Pittsburgh
2005
Endoplasmic reticulum (ER) stress is associated with liver injury and fibrosis, yet the hepatic factors that regulate ER stress-mediated inflammasome activation remain unknown. Here, we report farnesoid X receptor (FXR) inhibits stress-induced NACHT, LRR, PYD domains-containing protein 3 (NLRP3) in hepatocytes. In patients hepatitis B virus (HBV)-associated failure or non-alcoholic fatty disease, mice injury, FXR levels inversely correlated extent of NLRP3 activation. Fxr deficiency...
Background: Deoxynivalenol (DON) and zearalenone (ZEN) are common food contaminants produced by Fusarium sp. Mycotoxins a potential health hazard because of their toxicological effects on both humans farmed animals. Methods: We analyzed three groups pigs: control group (fed standard diet), the DON ZEN groups, fed diet containing 8 mg/kg 0.8 respectively, for four weeks. Results: exposure decreased body weight (BW), average daily feed intake (ADFI), conversion rate (FCR), serum levels...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an infectious with multiple symptoms, such as fever over 37.5°C, cough, dyspnea, and pneumonia.In our research, microRNAs (miRNAs) binding to the genome sequences of (SARS-CoV), Middle East respiratory-related (MERS-CoV), SARS-CoV-2 were identified bioinformatic tools.Five miRNAs (hsa-miR-15a-5p, hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-16-5p, hsa-miR-196a-1-3p) found commonly bind...
Abstract Amlexanox is an anti-inflammatory and anti-allergic agent used clinically for the treatment of aphthous ulcers, allergic rhinitis, asthma. Recent studies have demonstrated that amlexanox, a selective inhibitor IkB kinase epsilon (IKKε) TANK-binding 1 (TBK1), suppresses range diseases or inflammatory conditions, such as obesity-related metabolic dysfunction type 2 diabetes. However, effects amlexanox on neuroinflammatory responses to not yet been comprehensively studied. In this...
Toll-like receptor 7 (TLR7) signaling predominantly regulates production of type I interferons (IFNs), which has been suggested in clinical studies to be antifibrotic. However, the mechanistic role TLR7-type IFN axis liver fibrosis not elucidated. In present study, was induced wild-type (WT), TLR7-deficient, and IFN-α/β receptor-1 (IFNAR1)-deficient mice TLR7-mediated assessed cells isolated from these mice. TLR7-deficient IFNAR1-deficient were more susceptible than WT mice, indicating that...
Abstract Ocular infection with HSV results in a blinding immunoinflammatory lesion known as herpetic stromal keratitis (HSK). Early preclinical events include inflammatory cell, mainly neutrophils, infiltration of the stroma, and neovascularization. To further evaluate role neutrophils pathogenesis, was compared BALB/c mice same background, but lacking CXCR2, receptor for chemokines involved neutrophil recruitment. Our show clear differences outcome ocular CXCR2−/− control mice. Thus,...
Abstract Recently, a possible link between toll-like receptor 7 (TLR7) and liver disease was suggested, although it limited to fibrosis. Based on this report, we investigated whether TLR7 has pivotal role in non-alcoholic fatty (NAFLD). The signaling pathway, which is activated by imiquimod (TLR7 ligand) naturally, induced autophagy released insulin-like growth factor 1 (IGF-1) into medium from hepatocytes. Lipid accumulation unsaturated acid (UFA; arachidonic acid:oleic = 1:1) hepatocytes,...
A highly contagious virus, severe acute respiratory syndrome coronavirus 2, caused the disease 19 (COVID-19) pandemic (SARS-CoV-2). SARS-CoV-2 genetic variants have been reported to circulate throughout COVID-19 pandemic. symptoms include symptoms, fever, muscle pain, and breathing difficulty. In addition, up 30% of patients experience neurological complications such as headaches, nausea, stroke, anosmia. However, neurotropism infection remains largely unknown. This study investigated...
This report evaluates the role of interaction between glucocorticoid-induced tumor necrosis factor receptor (GITR) and GITR ligand (GITR-L) in immuno-inflammatory response to infection with herpes simplex virus (HSV). Both GITR-L were transiently upregulated after ocular HSV infection, on antigen-specific T cells antigen-presenting cells, respectively, draining lymph node (DLN). In addition, virus-specific T-cell responses DLN spleen enhanced by anti-GITR antibody treatment, an outcome...
Abstract Ocular infection with HSV may result in the blinding immunoinflammatory lesion stromal keratitis (SK). This represents a CD4+ T cell-mediated immunopathologic both humans and mouse model. Early events pathogenesis that set stage for SK are poorly understood. The present study evaluates role of IL-1 using transgenic overexpresses receptor antagonist (IL-1ra) protein. Such mice were markedly resistant to compared IL-1ra−/− C57BL/6 control animals. resistance was shown be consequence...
Abstract The host-associated defence system responsible for the clearance of porcine reproductive and respiratory syndrome virus (PRRSV) from infected pigs is currently poorly understood. To better understand dynamics host–pathogen interactions, seventy-five 100 with PRRSV-JA142 25 control were euthanized at 3, 10, 21, 28 35 days post-challenge (dpc). Blood, lung, bronchoalveolar lavage (BAL) bronchial lymph node (BLN) samples collected to evaluate cellular immune responses. humoral...
Adeno-associated virus (AAV)-mediated gene delivery holds great promise for therapy. However, the non-invasive of AAV lung tissues has not been adequately established. Here, we revealed that intratracheal administration an appropriate amount AAV2/8 predominantly targets tissue. AAV-mediated used in this study induced expression desired protein parenchymal cells, including alveolar type II cells. We harnessed technique to develop severe acute respiratory syndrome coronavirus 2...
From 2017 to 2023, 196 dead Korean water deer (Hydropotes inermis argyropus), a common wildlife species in Republic of Korea, were necropsied. In one deer, bovine tuberculosis infection was confirmed through necropsy, histopathologic examination, and microbiologic diagnosis.
ABSTRACT An 11‐year‐old male castrated cat was presented for dyspnoea. Cardiomegaly and pulmonary oedema were identified radiographically. Echocardiography lesions of suspected aortic dissection consisting a false lumen filled with echogenic material at the level valve insufficiency. The developed pericardial effusion chylothorax three months after initial diagnosis. A computed tomography exam revealed wall defect allowing connection between true beak‐, spiral‐shaped compressing lumen, which...