A5040637855- Pancreatic function and diabetes
- Colorectal Cancer Surgical Treatments
- Erythrocyte Function and Pathophysiology
- Cellular transport and secretion
- Colorectal and Anal Carcinomas
- Cancer Treatment and Pharmacology
- Microtubule and mitosis dynamics
- Genetic and Kidney Cyst Diseases
- Multiple and Secondary Primary Cancers
- Renal and related cancers
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Phagocytosis and Immune Regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Immune cells in cancer
- Breast Implant and Reconstruction
- Wnt/β-catenin signaling in development and cancer
- Neutropenia and Cancer Infections
- Advances in Oncology and Radiotherapy
- Gastrointestinal Bleeding Diagnosis and Treatment
- Renal cell carcinoma treatment
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Women's cancer prevention and management
Washington University in St. Louis
2017-2018
University of Colorado Anschutz Medical Campus
2015-2017
University of Colorado Denver
2015
University of Colorado Boulder
2015
Hôtel-Dieu de Québec
1983
Université de Sherbrooke
1977-1978
Signaling by epidermal growth factor receptor (EGFR) is controlled endocytosis. However, mechanisms of EGFR endocytosis remain poorly understood. Here, we found that the mutant lacking known ubiquitylation, acetylation and clathrin adaptor AP-2-binding sites (21KRΔAP2) was internalized at relatively high rates via clathrin-dependent pathway in human duodenal adenocarcinoma HuTu-80 cells. RNA interference analysis revealed this residual internalization strongly inhibited depletion Grb2 E2...
Centrosome number is tightly controlled to ensure proper ciliogenesis, mitotic spindle assembly, and cellular homeostasis. amplification (the formation of excess centrosomes) has been noted in renal cells patients animal models various types cystic kidney disease. Whether this defect plays a causal role cystogenesis remains unknown. Here, we investigate the consequences centrosome during development, homeostasis, after injury. Increasing vivo perturbed proliferation differentiation...
ABSTRACT The post-mitotic midbody (MB) is a remnant of cytokinesis that can be asymmetrically inherited by one the daughter cells following cytokinesis. Until recently, MB was thought to degraded immediately However, recent evidence suggests protein-rich organelle accumulates in stem cell and cancer populations, indicating it may have functions. Here, we investigate role FYCO1, an LC3-binding protein (herein, LC3 refers MAP1LC3B), its function regulating degradation MBs. We show FYCO1...
ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping early-career researchers promote themselves alongside their papers. Lai Kuan Dionne and Eric Peterman are co-first on ‘FYCO1 regulates accumulation post-mitotic midbodies by mediating LC3-dependent midbody degradation’, Science. post-doctoral associate lab Moe Mahjoub at Washington University School Medicine, investigating molecular mechanisms secretion health...