A5039557222- Pharmacological Effects and Assays
- Synthesis and biological activity
- Plant chemical constituents analysis
- Sesquiterpenes and Asteraceae Studies
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Synthesis and Biological Activity
- Analytical Chemistry and Chromatography
- Heavy Metals in Plants
- Cancer therapeutics and mechanisms
- Advanced Chemical Sensor Technologies
- Bioactive Compounds and Antitumor Agents
Universidad de Colima
2019-2025
University of Padua
2020-2022
A series of three 1,3-phenylene bis-oxamides 3a–c, structurally related to the GPR35 receptor-agonist drug lodoxamide, has been synthesized by reacting bis-oxalamates 2a and 2b with amines. The obtained compounds were characterized 1H 13C NMR, IR spectroscopy, they showed characteristic signals for aromatic, N―H, C=O groups. Molecular structure was determined using single-crystal X-ray diffraction. supramolecular architecture is driven N―H···O=C, N―H···N, C—H···π, O=C···O=C interactions...
A selective, sensitive and precise reversed phase HPLC-DAD method was developed validated for the simultaneous determination of six phenolic acids in aqueous extract their hydrolyzed forms prepared from Solanum elaeagnifolium Cav., Solanaceae, Ampelocissus acapulcensis (Kunth) Planch., Vitaceae, or Brosimum alicastrum Sw., Moraceae. The new showed good linearity (r > 0.999) a relatively wide concentration range (0.5–100 mg/l). limits detection quantification compounds were 0.097–0.467 mg/l...
The synthesis of a small library 8-substituted 2-methyl-5,6,7,8-tetrahydroquinoline derivatives is presented. All the compounds were tested for their antiproliferative activity in non-cancer human dermal microvascular endothelial cells (HMEC-1) and cancer cells: T-lymphocyte (CEM), cervix carcinoma (HeLa), (HMEC-1), colorectal adenocarcinoma (HT-29), ovarian (A2780), biphasic mesothelioma (MSTO-211H). Compounds 3a, 5a, 2b, showing significant IC50 values against whole panel selected cells,...
Triclosan (TCS) is used in many health care products as a broad-spectrum antimicrobial and disinfectant agent; however, it currently considered an emerging pollutant. The present study aimed to develop analytical HPLC method coupled Diode Array Detector for the TCS determination toothpaste. Method development involved optimization of separation sample preparation. For chromatographic optimization, different RP columns aqueous mobile phases were addressed. optimized was achieved around 3...