A5024409808- Cancer Cells and Metastasis
- Cancer and Skin Lesions
- Cancer-related Molecular Pathways
- Thyroid Cancer Diagnosis and Treatment
- TGF-β signaling in diseases
- Lymphoma Diagnosis and Treatment
- Cancer Research and Treatments
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Dermatologic Treatments and Research
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Wnt/β-catenin signaling in development and cancer
- Renal and related cancers
- Vascular Tumors and Angiosarcomas
- Ear and Head Tumors
- Tumors and Oncological Cases
- Viral-associated cancers and disorders
- Genetic and rare skin diseases.
Kangbuk Samsung Hospital
2016-2025
Sungkyunkwan University
2016-2025
University of California, Irvine
2011
Samsung Medical Center
2009
Hallym University
2001-2004
Korea University Medical Center
2004
Hangang Sacred Heart Hospital
2002
Hallym University Medical Center
2002
The study aims to determine whether type and density of tumour-infiltrating lymphocytes (TILs) can predict the clinical course in gastric cancer. Gastric carcinomas (n=220) were immunostained for CD3, CD8, CD20, CD45RO evaluated clinicopathologic characteristics. Number TILs that positively each marker counted using NIH ImageJ software. Tumours grouped into low- high-density groups (CD3, CD45RO). densities CD3+, CD8+, CD45RO+ found be independent predictors lymph node metastasis by...
The effects of exendin-4 on Sirt1 expression as a mechanism reducing fatty liver have not been previously reported. Therefore, we investigated whether the beneficial treatment are mediated via in high-fat (HF) diet-induced obese C57BL/6J mice and related cell culture models. Exendin-4 decreased body weight, serum free acid (FA), triglyceride levels HF-induced mice. Histological analysis showed that reversed hepatic accumulation lipids inflammation. increased mRNA protein its downstream...
In a fully automatic cell extraction process, one of the main issues to overcome is problem related extracting overlapped nuclei since such will often affect quantitative analysis images. this paper, we present an unsupervised Bayesian classification scheme for separating nuclei. The proposed approach first involves applying distance transform topographic surface generated by viewed as mixture Gaussians in algorithm. order learn distribution surface, parametric expectation-maximization (EM)...
Carcinogenesis and tumor growth are associated with chronic inflammation the host immune system. Here, we investigated clinical significance relationship between tumor-infiltrating lymphocytes (TILs) hematologic parameters in patients breast cancer. Invasive ductal cancer (N = 145) who underwent surgery were retrospectively evaluated. Samples obtained using a core needle biopsy for CD8+, FOXP3+ TIL assessment. Blood lymphocytes, neutrophils, monocytes, platelets by peripheral venous...
Although mucosal mast cell tryptase is known to significantly increase intestinal permeability, the relationship between cells and permeability remains unclear. The objective of this study was evaluate correlation among activity count.Rectal biopsies from 16 patients with diarrhea-predominant irritable bowel syndrome (IBS-D) 7 normal subjects were assessed for macromolecular using horseradish peroxidase in Ussing chambers. In addition, levels immunohistochemically quantified via image...
Collagen triple helix repeat-containing 1 (CTHRC1) is known to be aberrantly upregulated in most human solid tumors, although the functional roles of CTHRC1 colorectal cancer remain unclear. In this study, we investigated occurrence upregulation and its role vivo vitro. The expression profile clinical importance were examined by reverse transcription-polymerase chain reaction immunohistochemical analyses normal tumor patient samples. was detectable tissues, but also highly expressed...
To clarify possible roles of adhesion molecules including E‐cadherin, β‐ and γ‐catenin, CD44s, CD44v6, CD56, CD99 in ovarian serous neoplasms, an immunohistochemical study was undertaken for 23 benign, 40 borderline, 95 malignant neoplasms using tissue microarray (TMA). Significantly reduced expression overexpression were more frequently observed adenocarcinomas than benign borderline tumors. Expression CD44v6 nuclear γ‐catenin detected only tumors adenocarcinomas. Reduced E‐cadherin also...
Tristetraprolin (TTP) is an AU-rich element-binding protein that regulates mRNA stability. Here, we report TTP suppress the growth of human colon cancer cells both in vivo and vitro by regulating expression vascular endothelial factor (VEGF). colonic tissues was markedly decreased adenocarcinoma compared with normal mucosa adenoma. VEGF higher than Specific inhibition RNA-interference increased cultured cells, overexpression it. In addition, elevated level luciferase linked to a 3' terminal...
Background Sirt6 has been implicated in the regulation of hepatic lipid metabolism and development steatosis. The aim this study was to address potential role protective effects rosiglitazone (RGZ) on Methods To investigate effect RGZ steatosis, rats were treated with (4 mg·kg−1·day−1) by stomach gavage for 6 weeks. involvement RGZ's evaluated knockdown AML12 mouse hepatocytes. Results treatment ameliorated accumulation increased expression Sirt6, peroxisome proliferator-activated receptor...
Purpose:The molecular mechanisms that are responsible for the initiation and progression of breast cancers largely unknown.This study was to analyze cyclin B1, cdc2, p53 p16 tumor suppressor genes in human cancer. Materials Methods:To investigate role pathogenesis carcinomas, 98 cases were examined by immunohistochemical method.The correlations expression with various clinico-pathologic findings analysed.Results: In normal tissues, cdc2 weakly expressed, while not expressed.On other hand,...
Background Tendinopathy (pain and tendon degeneration) is associated with repetitive use mechanical overload. However, the etiology of tendinopathy remains unclear. Clarification histologic molecular changes to stress could provide better understanding Achilles disorders related stress. Questions/Purposes We asked whether simulating overuse induced (1) in rats similar tendinosis (increased cellularity fibrocytes, increased disorganization collagen fiber, roundness nucleus fibrocyte), (2)...
Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that play a pivotal role in aggressive behaviours, such as rapid tumour growth, invasion, and metastasis, of several types solid tumours. In particular, stromal MMP-2 plays important roles the progression malignant tumours, but most clinical studies have focused on tumoural -9 expression, not expression. One hundred seventy-seven cases diagnosed invasive ductal carcinoma breast between 2000 2005 were included this study....
Previous studies have demonstrated aberrant Brahma-related gene 1 (BRG1) expression in various tumor types. Increased BRG1 has recently been shown to correlate with aggressive oncogenic behavior many different types of human cancer. However, the role breast cancer development and progression is not fully understood.We evaluated 224 patients invasive ductal carcinoma (IDC) using tissue microarray samples immunohistochemistry. We also investigated whether status associated clinicopathological...
Background Matrix metalloproteinase-9 (MMP-9) is associated with remodelling of the extracellular matrix and invasion in various cancers. Identifying proteins connected to high MMP-9 expression important explaining its mechanisms. Our study aims shed light on genes discuss their clinical impact breast cancer. Methods We evaluated 173 cancer cases from Kangbuk Samsung Hospital, 1964 Molecular Taxonomy Breast Cancer International Consortium database serving as a validation cohort. investigated...
<title>Abstract</title> Cancer-associated fibroblasts promote tumor progression through growth facilitation, invasion, and immune evasion. This study investigated the impact of activated cancer-associated (aCAFs) on survival outcomes, response, molecular pathways in distal bile duct (DBD) cancer. We analyzed 469 patients (418 from our cohort 51 The Cancer Genome Atlas) with DBD adenocarcinoma. aCAFs were evaluated using hematoxylin eosin staining. developed a machine learning-based...
Abstract Background. Helicobacer pylori infection is a major gastric cancer risk factor. Deficient DNA mismatch repair (MMR) caused by H. may underlie microsatellite instability (MSI) in the epithelium and represent mechanism of mutation accumulation mucosa during early stages ‐associated carcinogenesis. In this study, we examined expression MMR protein (hMLH1 hMSH2) patients with chronic before after eradication infection. Materials methods. Gastric tissue samples were collected from 60...
We investigated the expression of 10 adhesion molecules (alpha-catenin, beta-catenin, gamma-catenin, CD44, CD44v6, ICAM-1, CD56, CEA, E-cadherin, and CD99) in 46 gallbladder carcinomas, 14 adenomas, 15 low-grade dysplasias, nine intestinal metaplasias, 20 samples normal epithelium by immunohistochemistry. The was altered carcinomas adenomas. In increased CD44v6 observed, together with decreased alpha/beta/gamma-catenin CD99. aberrant as well reduced alpha/beta/gamma- E-cadherins, noted....
Background: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has standardized the reporting of thyroid cytology specimens.The objective current study was to evaluate nationwide usage TBSRTC and assess malignancy rates in each category Korea.Methods: Questionnaire surveys were used data collection on fine needle aspiration (FNA) nodules at 74 institutes 2012.The incidences follow-up diagnosed from January December, 2011, institute also collected analyzed.Results: Sixty out...
Laminin 332 (LN332) is a basally expressed extracellular matrix protein that enhances the migration and invasion of breast carcinoma cells. The goal this study was to examine LN332 expression carcinoma. Triple negative carcinomas lack estrogen receptor (ER), progesterone (PR) HER2 positivity. Immunohistochemistry for ER, PR, HER2, dual silver in situ hybridization gene were used define phenotype 243 cancers biopsies or arrays. revealed 70% triple stained LN332. Cytokeratins 5/6 (CK5/6),...