A5053581888- Natural Antidiabetic Agents Studies
- Antioxidant Activity and Oxidative Stress
- Phytochemical and Pharmacological Studies
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
- Drug-Induced Hepatotoxicity and Protection
- Muscle metabolism and nutrition
- Ubiquitin and proteasome pathways
- Microbial Natural Products and Biosynthesis
- Nicotinic Acetylcholine Receptors Study
- Endoplasmic Reticulum Stress and Disease
- Receptor Mechanisms and Signaling
- Muscle Physiology and Disorders
- Vitamin D Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Traditional and Medicinal Uses of Annonaceae
- Chemical synthesis and alkaloids
National Institute of Nutrition
2016-2022
Karolinska Institutet
2016
Karolinska University Hospital
2016
University of Hyderabad
2016
The cholinergic anti-inflammatory pathway (CAP) primarily functions through acetylcholine (ACh)-alpha7 nicotinic receptor (α7nAChR) interaction on macrophages to control peripheral inflammation. Interestingly, ACh can also bind α7nAChRs microglia resulting in neuroprotective effects. However, effects astrocytes remain elusive. Here, we investigated the of nicotine, an agonist, cytokine and cholinesterase production immunocompetent human stimulated with interleukin 1β (IL-1β) vitro. In...
Abstract Altered activity of the proteolytic machine—the 26S proteasome is observed in many disease conditions. Hence, either inhibition or activation thought to be a novel therapy for treatment certain diseases such as cancer and neurodegenerative disorders. In this study, we tested potential cinnamon one its active ingredients, procyanidin‐B2 (PCB2), inhibiting catalytic activities suppressing prostate cell growth. Proteasome were measured using fluorogenic substrates specific different...
Cinnamon contains bioactive substances with diverse medicinal properties. We investigated the anticancer potential of abundant monophenols from cinnamon, namely, cinnamaldehyde, cinnamic acid, and eugenol, by hypothesizing that they possess proteasome inhibitory activities capable suppressing cancer cell proliferation inducing apoptosis. This hypothesis was tested evaluating compounds, assessing downstream molecular cellular events are known to be impacted inhibitors. The cinnamon compounds...
The enantiopure synthesis of clavatustides A (<bold>1</bold>) and B (<bold>3</bold>) were accomplished by a seven step synthetic protocol starting from commercially available (<italic>R</italic>)-phenyllactic acid.
Abstract Cinnamon and its bioactive compounds inhibit prostate cancer cell proliferation in vitro. The aim of the current study was to assess chemopreventive efficacy cinnamon (CN) vivo using N-methyl-N-nitrosourea (MNU) testosterone (T) induce carcinogenesis male Wistar/National Institute Nutrition rats. Cancer-induced (CI) rats (n = 10) developed prostatic hyperplasia intraepithelial neoplasia. These histopathologic changes were diminished CI fed for 4 months with diets supplemented either...
<div>Abstract<p>Cinnamon and its bioactive compounds inhibit prostate cancer cell proliferation <i>in vitro</i>. The aim of the current study was to assess chemopreventive efficacy cinnamon (CN) vivo</i> using N-methyl-N-nitrosourea (MNU) testosterone (T) induce carcinogenesis in male Wistar/National Institute Nutrition rats. Cancer-induced (CI) rats (<i>n</i> = 10) developed prostatic hyperplasia intraepithelial neoplasia. These histopathologic...
<div>Abstract<p>Cinnamon and its bioactive compounds inhibit prostate cancer cell proliferation <i>in vitro</i>. The aim of the current study was to assess chemopreventive efficacy cinnamon (CN) vivo</i> using N-methyl-N-nitrosourea (MNU) testosterone (T) induce carcinogenesis in male Wistar/National Institute Nutrition rats. Cancer-induced (CI) rats (<i>n</i> = 10) developed prostatic hyperplasia intraepithelial neoplasia. These histopathologic...