A5028662924- Autoimmune and Inflammatory Disorders Research
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Extracellular vesicles in disease
- Neonatal Respiratory Health Research
- Adolescent and Pediatric Healthcare
- Family and Disability Support Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Cerebral Palsy and Movement Disorders
- Lymphoma Diagnosis and Treatment
- Diabetes and associated disorders
- Congenital heart defects research
- Adrenal Hormones and Disorders
- Congenital Heart Disease Studies
- Myasthenia Gravis and Thymoma
- Sphingolipid Metabolism and Signaling
- Tracheal and airway disorders
- Hormonal Regulation and Hypertension
- Childhood Cancer Survivors' Quality of Life
National University Hospital of Iceland
2017-2024
University of Gothenburg
2013-2022
Exosomes are nano‐sized vesicles released by cells into the extracellular space and have been shown to be present in thymic tissue both mice humans. The source of exosomes is however still an enigma hence it not known whether epithelial (TECs) able produce exosomes. In this work, we cultured human TECs isolated These carry tissue‐restricted antigens (TRAs), for example, myelin basic protein desmoglein 3. presence TRAs indicates a possible role epithelium‐derived selection process thymocytes....
Exosomes are nanosized membrane-bound vesicles that released by various cell types and capable of carrying proteins, lipids RNAs which can be delivered to recipient cells. play a role in intercellular communication have been described mediate immunologic information. In this article we report the first isolation characterization exosomes from human thymic tissue. Using electron microscopy, particle size determination, density gradient measurement, flow cytometry, proteomic analysis microRNA...
Down syndrome (DS), caused by trisomy of chromosome 21, is associated with immunological dysfunctions such as increased frequency infections and autoimmune diseases. Patients DS share clinical features, manifestations specific autoantibodies, patients affected polyendocrine type 1. Autoimmune 1 mutations in the regulator (AIRE) gene, located on which regulates expression tissue-restricted Ags (TRAs) thymic epithelial cells. We investigated AIRE TRAs control tissue using quantitative PCR....
Abstract Extensive knowledge has been gained the last years concerning mechanisms underlying selection of single positive thymocytes in thymic medulla. Less is known regarding other important processes medulla such as regulation late stage thymocyte maturation. We have previously reported that exosomes are abundant thymus with a phenotype indicates an epithelial cell origin and immunoregulatory properties. In this study we use vitro system to investigate effects on maturation well nTreg...
Population-based neonatal screening using T-cell receptor excision circles (TRECs) identifies infants with profound T lymphopenia, as seen in cases of severe combined immunodeficiency, and a subgroup 22q11 deletion syndrome (22q11DS).To investigate the long-term prognostic value low levels TRECs newborns 22q11DS.Subjects 22q11DS at birth (22q11Low, N=10), matched subjects normal (22q11Normal, healthy controls (HC, N=10) were identified. At follow-up (median age 16 years), clinical...
Abstract Background Juvenile idiopathic arthritis is characterised by recurring episodes of acute inflammation, with joint swelling in one or more joints, often accompanied pain. These can now be controlled better than the past because a new category medications. However, despite stable disease activity, pain may continue to cause problems children juvenile and reduce their performance routine physical activities participation social school activities. Aim To evaluate prevalence pain,...
Dysregulated central tolerance predisposes to autoimmune diseases. Reduced thymic output as well compromised B cell checkpoints have been proposed in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim this study was investigate neonatal levels T-cell receptor excision circles (TRECs) and kappa-deleting element (KRECs), markers T- B-cell at birth, patients with early onset JIA. TRECs KRECs were quantitated by multiplex qPCR from dried blood spots (DBS), collected 2–5 days after...
Aims 1) to map questions of pain from a survey the International Classification Functioning, Disability and Health (ICF) 2) compare impact musculoskeletal on functioning based different components ICF in children with juvenile idiopathic arthritis (JIA) age-matched peers.
Purpose: To compare physical activity in children with juvenile idiopathic arthritis and age-matched peers. Materials methods: Daily was measured for seven consecutive days activPALTM accelerometer 8–18- year-old (n=28) age- sex-matched controls (n=35). The main variables were daily steps duration of time moderate to vigorous activity. A mixed model analysis variance used statistical analysis. Results: groups comparable terms age, height, weight, body mass index sex ratio. There no...