A5037939359- Radiopharmaceutical Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Radioactive element chemistry and processing
- Metal complexes synthesis and properties
University of Padua
2022-2024
A series of macrocyclic ligands were considered for the chelation Pb2+: 1,4,7,10-tetrakis[2-(methylsulfanyl)ethyl]-1,4,7,10-tetraazacyclododecane (DO4S), 1,4,7-tris[2-(methylsulfanyl)ethyl]-1,4,7,10-tetraazacyclododecane (DO3S), 1,4,7-tris[2-(methylsulfanyl)ethyl]-10-acetamido-1,4,7,10-tetraazacyclododecane (DO3SAm), 1,7-bis[2-(methylsulfanyl)ethyl]-1,4,7,10-tetraazacyclododecane-4,10-diacetic acid (DO2A2S), 1,5,9-tris[2-(methylsulfanyl)ethyl]-1,5,9-triazacyclododecane (TACD3S),...
The complexes formed between Pb2+ and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) were reinvestigated in aqueous solutions using a combination of pH potentiometry, UV-vis spectroscopy, NMR spectroscopy. thermodynamic data supported by kinetics assays. Differently protonated complexes, i.e., [PbH3L]+, [PbH2L], [PbHL]-, [PbL]2-, detected, the corresponding stability constants (logβ) at T = 298 K I 0.1 M NaCl 33.1 ± 0.2, 32.00 0.06, 29.28 25.3 0.1, respectively. Results...