A5052324556- Occupational and environmental lung diseases
- Autophagy in Disease and Therapy
- Air Quality and Health Impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- MicroRNA in disease regulation
- Scientific Research and Studies
- Ocular Diseases and Behçet’s Syndrome
- Biochemical Acid Research Studies
- Microbial Community Ecology and Physiology
- Plant responses to elevated CO2
- Radioactivity and Radon Measurements
- Biomarkers in Disease Mechanisms
- Therapeutic Uses of Natural Elements
- Nanoparticles: synthesis and applications
- Aquatic Ecosystems and Phytoplankton Dynamics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Tryptophan and brain disorders
- Circular RNAs in diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Nasolacrimal Duct Obstruction Treatments
- Protein Interaction Studies and Fluorescence Analysis
- Inflammasome and immune disorders
- Indoor Air Quality and Microbial Exposure
- Head and Neck Surgical Oncology
Southwest Medical University
2015-2025
Qinghai Provincial Peoples Hospital
2024
Peking University People's Hospital
2015-2022
Peking University
2015-2022
First Affiliated Hospital of Sichuan Medical University
2010-2015
Ministry of Education of the People's Republic of China
2015
Jintan People's Hospital
2011
Jiangsu University
2011
Abstract Age-related macular degeneration (AMD) is the leading cause of central vision loss in elderly. Degeneration retinal pigment epithelial (RPE) cells a crucial causative factor responsible for onset and progression AMD. A2E, major component toxic lipofuscin implicated AMD, deposited RPE with age. However, mechanism whereby A2E may contribute to pathogenesis AMD remains unclear. We demonstrated that was danger signal cells, which induced autophagy decreased cell viability concentration-...
Abstract Background Proton pump inhibitors (PPIs) are one of the most frequently prescribed classes drug in world and there is a growing number publications on correct versus incorrect use PPIs worldwide. The knowledge among medical staff essential for improving rationality PPI application. present study aimed to investigate awareness, attitude behavior toward Southwest China. Methods descriptive-analytical was conducted 900 from three professional groups (300 doctors, 300 nurses...
Microcystins (MCs), as the most dominant bloom-forming strains in eutrophic surface water, can induce hepatotoxicity by oxidative stress. Alpha-lipoic acid (α-LA) is a super antioxidant that synthesis of antioxidants, such glutathione (GSH), nuclear factor erythroid 2-related 2 (Nrf2). However, potential molecular mechanism α-LA regeneration GSH remains unclear. The present study aimed to investigate whether could reduce toxicity MCs induced human hepatoma (HepG2), Bel7420 cells, and BALB/c...
The increased drug resistance and metastasis of melanoma resulted in poor prognosis patients. Here, we designed synthesized a novel hemicyanine-based fluorescent probe ZWZ-3, investigated its application for imaging treatment both vitro vivo. ZWZ-3 preferentially accumulated cells via process that depended on the organic anion-transporting polypeptide (OATP), which targeted mitochondria hemicyanine cationic nitrogen. In addition, effect molecular mechanism melanoma. studies showed promoted...
Melanoma is the most invasive skin cancer, with a high mortality rate. However, existing therapeutic drugs have side effects, low reactivity, and lead to drug resistance. As power source in cells, mitochondria play an important role survival of cancer cells are target for tumor therapy. This study aimed develop new anti-melanoma compound that targets mitochondria, evaluate its effect on proliferation metastasis melanoma explore mechanism action. The novel mitochondria-targeting compound,...
Man-made mineral fibers (MMMFs) are substitutes for asbestos. MMMFs widely used as insulation, but their molecular mechanisms underlying the tumorigenic effects in vivo have been poorly studied. For this reason, work aimed to explore properties and carcinogenic of MMMFs. The three MMMFs, rock wool (RW), glass (GFs), ceramic (CFs), were prepared into respirable dust. Particle size, morphology, chemical composition analyzed by laser particle analyzer, scanning electron microscope, X-ray...
To investigate T cell subtypes and their functions in liver immune microenvironments among patients with alveolar echinococcosis (AE) using single-cell RNA sequencing (scRNA-seq).
Considering the high contents of minerals and potential health risk mineral dusts to human environment, this paper was aimed figure out toxic effect mechanism four common particles (quartz, albite, sericite, montmorillonite). Cytotoxicity assays for cell viability (MTT assay), membrane integrity (LDH oxidative stress (H2O2 assay) inflammatory cytokines (TNF-α IL-6 were applied. The results showed influence these on A549 followed order momtmorillonite > cericite≥quartz albite. There no...