A5019138305- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Fungal Biology and Applications
- Chemical Synthesis and Analysis
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Synthetic Organic Chemistry Methods
- Advanced Synthetic Organic Chemistry
- Plant Genetic and Mutation Studies
- Bioactive Compounds and Antitumor Agents
- Microbial Natural Products and Biosynthesis
- Indoor Air Quality and Microbial Exposure
- Single-cell and spatial transcriptomics
- Molecular spectroscopy and chirality
- Infectious Diseases and Mycology
- Asthma and respiratory diseases
- Mycotoxins in Agriculture and Food
- Axial and Atropisomeric Chirality Synthesis
- Plant Pathogens and Resistance
- Phosphodiesterase function and regulation
- Immune Response and Inflammation
- Garlic and Onion Studies
- Receptor Mechanisms and Signaling
St. Anne's University Hospital Brno
2024
Czech Academy of Sciences, Institute of Biophysics
2021-2024
University Hospital Brno
2024
Czech Academy of Sciences
2024
Masaryk University
2021-2023
We report a new synthetic strategy for the flexible preparation of forskolin-like molecules. The approach is different from previously published works and employs convergent assembly tricyclic labdane-type core pre-functionalized cyclic building blocks. Stereoselective Michael addition enabled fragment coupling with excellent control over three newly created contiguous stereocenters, all-carbon quaternary centers included. Silyl enol ether-promoted ring-opening metathesis paired ring closure...
Background: Pseurotins, a family of secondary metabolites different fungi characterized by an unusual spirocyclic furanone-lactam core, are suggested to have biological activities including the modulation immune response. Purpose: Complex characterization effects pseurotin D on human lymphocyte activation in order understand potential modulate response humans. Methods: CD4+ and CD8+ T cells CD19+ B isolated from blood were activated various activators simultaneously with treatment. The...
We report flexible synthesis of new unsymmetrically 2,6-disubstituted benzoquinones (33 examples) and a systematic study their reactivity in the Diels-Alder reaction. The reactions selected unsymmetrical with seemingly similar substituents were found to proceed high regioselectivity formation experimentally observed main products was rationalized by theoretical (DFT) calculations. findings can be exploited convenient preparation densely substituted stereochemically defined decalins unique...
Abstract The cyclic adenosine monophosphate (cAMP) signaling pathway is involved in various physiological and pathophysiological processes. Forskolin (FSK), a labdane diterpene well known as an activator of cAMP production, suggested to possess significant immunomodulatory potential. However, the specific effects elevated levels caused by FSK-mediated activation adenylate cyclase (AC) on T helper (Th) cell differentiation functions are still unclear. We speculated that increased Th cells...
Abstract We report a new synthetic strategy for the flexible preparation of forskolin‐like molecules. The approach is different from previously published works and employs convergent assembly tricyclic labdane‐type core pre‐functionalized cyclic building blocks. Stereoselective Michael addition enabled fragment coupling with excellent control over three newly created contiguous stereocenters, all‐carbon quaternary centers included. Silyl enol ether‐promoted ring‐opening metathesis paired...