A5076144834- Inflammatory Bowel Disease
- Microscopic Colitis
- Acute Lymphoblastic Leukemia research
- Adolescent and Pediatric Healthcare
- Gut microbiota and health
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced Chemical Sensor Technologies
- Pharmaceutical studies and practices
- Mental Health and Patient Involvement
- Epilepsy research and treatment
- Celiac Disease Research and Management
- Health Policy Implementation Science
- Neonatal Health and Biochemistry
- Tuberculosis Research and Epidemiology
- Analytical Chemistry and Chromatography
- Infant Nutrition and Health
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects and Toxicity Studies
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
Emma Kinderziekenhuis
2021-2025
Amsterdam University Medical Centers
2021-2024
Vrije Universiteit Amsterdam
2021-2024
University of Amsterdam
2021-2023
Abstract Background Fecal metabolomic profiles differ between pediatric inflammatory bowel disease (IBD) patients and controls may provide new insights in the pathophysiology of IBD. The role amino acids, however, is not fully elucidated. We aimed to assess fecal acid Methods In this case-control study, treatment-naïve, newly diagnosed IBD a non-IBD control group, matched based on sex age, were included 2 tertiary centres. assessed using targeted high-performance liquid chromatography...
Setting research priorities together with children and young people (CYP) in James Lind Alliance (JLA) Priority Partnerships (PSPs) is an example of involving CYP from the beginning process. In these PSPs, can be involved steering groups, surveys, focus groups final priority-setting workshop. The success JLA PSPs evident, but it important to note that specific guidance has not been available on how involve aged under 18 years. We aimed collect experiences tips who have taken part a exercise...
The gut microbiota and its related metabolites differ between inflammatory bowel disease (IBD) patients healthy controls. In this study, we compared faecal volatile organic compound (VOC) patterns of paediatric IBD controls with gastrointestinal symptoms (CGIs). Additionally, aimed to assess if baseline VOC profiles could predict treatment response in patients. We collected samples from a cohort de novo therapy-naïve CGIs. VOCs were analysed using gas chromatography–ion mobility spectrometry...
Colonoscopy is the gold standard for diagnosing inflammatory bowel disease (IBD). However, this invasive procedure has a high burden pediatric patients. Previous research shown elevated fecal amino acid concentrations in children with IBD versus controls. We hypothesized that finding could result from increased proteolytic activity. Therefore, aim of study was to investigate whether protease-based profiling able discriminate between and Protease activity measured samples patients (Crohn's...
In the recent era of growing availability biological agents, role thiopurines needs to be reassessed with focus on toxicity. We assessed incidence and predictive factors thiopurine-induced adverse events (AE) resulting in therapy cessation pediatric inflammatory bowel disease (IBD), related thiopurine metabolites biochemical abnormalities, determined overall drug survival. performed a retrospective, single-center study children diagnosed IBD between 2000 2019 treated therapy. The AE survival...
Thioguanine (TG) has been shown as a safe alternative in adults with inflammatory bowel disease (IBD) who did not tolerate conventional thiopurines [azathioprine (AZA)/mercaptopurine]. However, data pediatric IBD are scarce. Therefore, we aimed to assess the safety of TG maintenance therapy.A retrospective, multicenter cohort study children on was performed Netherlands. TG-related adverse events (AE) were assessed and listed according common terminology criteria for AE.Thirty-six (median age...
This study aimed to evaluate the current clinical practice of Dutch pediatric gastroenterologists regarding surveillance for colorectal dysplasia and cancer in ulcerative colitis (UC), including adherence guidelines, initiation interval applied endoscopy techniques.A vignette-based survey was distributed among all 47 who are registered working Netherlands.Thirty-three treating children with UC, completed questionnaire (response rate 70%). Of these respondents, 23 (70%) do conduct endoscopic...
Abstract Objectives Antibodies to infliximab (ATIs) are associated with loss of response in children inflammatory bowel disease (IBD). We aimed describe the effectiveness strategies for treatment modification following ATI development pediatric IBD: (1) escalation; and (2) switching another anti‐TNF agent. Methods This multicenter retrospective study included IBD (4–18 years) on infliximab. Therapeutic drug monitoring (TDM) < 6 months corticosteroid‐free remission each strategy were...
Abstract Background Rapid infliximab (IFX) infusions have shown to be safe in adults with inflammatory bowel disease (IBD), but data on its safety paediatric IBD is limited. This study aimed assess the frequency and timing of infusion reactions (IR) children who received rapid (1-h) vs. standard (2-h) IFX infusions. Methods retrospective cohort included patients 4-18 years old, treated between January 2006 - November 2021 at two tertiary centres (AMC VUmc) Amsterdam, Netherlands. The AMC...
Accelerated infliximab (IFX) infusions have shown to be safe in adults with inflammatory bowel disease (IBD), but data on its safety pediatric IBD is limited. This study aimed assess the incidence and timing of infusion reactions (IR) children who received accelerated (1-h) versus standard (2-h) IFX infusions.This retrospective cohort included patients 4-18 years age initiated between January 2006 November 2021 at Amsterdam University Medical Centre, location Academic Centre (AMC) VU (VUmc)....