A5069667173- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Pregnancy and preeclampsia studies
- Ethics and Legal Issues in Pediatric Healthcare
- Parvovirus B19 Infection Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Diabetes Research and Management
- Renal and related cancers
- Ectopic Pregnancy Diagnosis and Management
- Healthcare Policy and Management
- Child and Adolescent Health
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
Wilhelmina Children's Hospital
2021-2025
University Medical Center Utrecht
2021-2024
Utrecht University
2023-2024
University Medical Center
2024
Noninvasive prenatal testing by cell-free DNA analysis is offered to pregnant women worldwide screen for fetal aneuploidies. In noninvasive testing, the fraction of in maternal circulation measured as a quality control parameter. Given that originates from placenta, might also reflect placental health and pregnancy adaptation.
To assess the association between low fetal fraction (FF) in prenatal cell-free DNA (cfDNA) testing and adverse pregnancy outcomes.We conducted a retrospective cohort study of participants TRIDENT-2 (Dutch nationwide government-supported offering cfDNA screening for aneuploidies) who received failed test result due to FF (<4%) April 2017 until February 2018. Outcome measures included pregnancy-induced hypertension (PIH), pre-eclampsia (PE), small gestational age neonates (SGA), spontaneous...
Objectives Noninvasive prenatal testing (NIPT) to screen for fetal aneuploidies by analysing cell-free DNA in maternal plasma is available pregnant women worldwide. In the future, scope of NIPT could potentially be expanded prediction adverse pregnancy outcomes. The objective this study was assess and compare preferences obstetric healthcare professionals on new test purpose NIPT. Design A discrete choice experiment designed participants’ use predict outcomes regarding three attributes...
(Abstracted from Am J Obstet Gynecol 2024;231:244.e1–244.e18) Noninvasive prenatal testing (NIPT) for Down, Edwards, and Patau syndromes is widely available. Its accuracy depends on a sufficient amount of fetal cell-free DNA (cfDNA) in maternal plasma.
Abstract Background Fetal fraction (FF) measurement is considered important for reliable noninvasive prenatal testing (NIPT). Using minimal FF threshold as a quality parameter under debate. We evaluated the variability in reported FFs of individual samples between providers and laboratories within single laboratory. Methods Genomic assessment European Molecular Genetics Quality Network provide joint proficiency NIPT. compared across all stratified according to test methodologies. A sample...
To explore the perspectives of pregnant women on broadening scope noninvasive prenatal testing (NIPT) from screening for foetal aneuploidies to prediction adverse pregnancy outcomes.
Background: Worldwide, non-invasive prenatal testing (NIPT) by cell-free DNA (cfDNA) analysis is offered to pregnant women screen for fetal aneuploidies. In NIPT, the fraction of cfDNA in maternal circulation measured as a quality control parameter. Since originates from placenta, might also reflect placental health and pregnancy adaptation. We assessed association between adverse outcomes.Methods: performed retrospective cohort study with singleton pregnancies opting NIPT June 2018 2019...
ABSTRACT Objective To assess the added value of fetal fraction cell‐free DNA in maternal circulation prediction adverse pregnancy outcomes. Design Retrospective cohort study. Setting Nationwide implementation study on non‐invasive prenatal testing (NIPT; TRIDENT‐2 study). Population Pregnant women Netherlands opting for NIPT between June 2018 and 2019. Methods Two logistic regression models were constructed each outcome. The first model (base model) included prognostic clinical parameters...
From an ethical point of view, there is important distinction between two types prenatal screening. The first these targets maternal or foetal conditions (e.g., infectious diseases, blood group sensitization) where early detection allows for interventions that improve the chances a healthy pregnancy outcome. second screens such as Down syndrome, timely diagnosis in most cases only choice preparation child with special needs termination pregnancy. Whereas former makes easy fit prevention aim...