A5037267871- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Meteorological Phenomena and Simulations
- Geophysics and Gravity Measurements
- Oceanographic and Atmospheric Processes
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
University of Washington
2007-2023
National Institute on Alcohol Abuse and Alcoholism
2020-2021
Seattle University
2021
Dopamine is broadly implicated in reinforcement learning, but how patterns of dopamine activity are generated poorly resolved. Here, we demonstrate that two ion channels, Kv4.3 and BKCa1.1, regulate the pattern neuron firing release on different time scales to influence separate phases reinforced behavior mice. Inactivation VTA neurons increases ex vivo pacemaker excitability associated with increased rate ramping dynamics before lever press a learned instrumental paradigm. Loss enhances...
The entire free-surface elevation field of a rotating fluid in the laboratory can be imaged and analysed, by using it as parabolic Newtonian telescope mirror. This ‘optical altimetry’ readily achieves precision better than 1 μm surface elevation. topography corresponds to pressure just beneath surface. It is streamfunction for geostrophic hydrostatic circulation, which resolved 0.1 mm s −1 . Still animated images thus produced, field, are value themselves, projected image (a speckle...
Abstract Despite the widely known role of dopamine in reinforcement learning, how patterns release that are critical to acquisition, performance, and extinction conditioned responses generated is poorly resolved. Here, we demonstrate coordinated actions two ion channels, Kv4.3 BKCa1.1, control pattern neuron firing on different time scales regulate separate phases reinforced behavior mice. Inactivation VTA neurons increases ex vivo pacemaker activity excitability associated with increased...