A5022529251- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Hepatocellular Carcinoma Treatment and Prognosis
- T-cell and B-cell Immunology
- Bone and Joint Diseases
- Synthesis and Biological Evaluation
- Lung Cancer Treatments and Mutations
- Hematological disorders and diagnostics
- Osteomyelitis and Bone Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Meningioma and schwannoma management
- Immunotherapy and Immune Responses
- Biosimilars and Bioanalytical Methods
- Cell death mechanisms and regulation
- Vasculitis and related conditions
- Neurofibromatosis and Schwannoma Cases
- Drilling and Well Engineering
- Lung Cancer Research Studies
- Full-Duplex Wireless Communications
- Glutathione Transferases and Polymorphisms
- Insect Resistance and Genetics
Holy Spirit University of Kaslik
2025
University of Calgary
2020-2024
Physiologie de la Reproduction et des Comportements
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Université de Tours
2024
Centre National de la Recherche Scientifique
2024
Edward Via College of Osteopathic Medicine
2024
Institute of Cancer Research
2020-2023
Moffitt Cancer Center
2020-2022
University of South Florida
2021
Abstract B cell maturation antigen (BCMA) target loss is considered to be a rare event that mediates multiple myeloma (MM) resistance anti-BCMA chimeric receptor T (CAR T) or bispecific engager (TCE) therapies. Emerging data report downregulation of G-protein-coupled family C group 5 member D (GPRC5D) protein often occurs at relapse after anti-GPRC5D CAR therapy. To examine the tumor-intrinsic factors promote MM escape, we performed combined bulk and single-cell whole-genome sequencing copy...
Bispecific T cell engagers (TCEs) have shown promise in the treatment of various cancers, but immunological mechanism and molecular determinants primary acquired resistance to TCEs remain poorly understood. Here, we identify conserved behaviors bone marrow-residing cells multiple myeloma patients undergoing BCMAxCD3 TCE therapy. We show that immune repertoire reacts therapy with state-dependent clonal expansion find evidence supporting coupling tumor recognition via major histocompatibility...
Adoptive T cell therapy is a promising for multiple myeloma (MM), but its efficacy hinges on understanding relevant biological and predictive markers of response. B maturation antigen (BCMA) key target in MM, with active development anti-BCMA engagers (TCE) chimeric receptor (CAR T) therapies. The regulation surface BCMA expression by MM cells, resulting the shedding soluble (sBCMA), has triggered debate surrounding significance sBCMA as marker potential impact treatment outcomes. In order...
The translocation t(11;14) occurs in 20% of patients with multiple myeloma (MM) and results the upregulation CCND1. Nearly two-thirds MM cells are BCL2 primed highly responsive to oral inhibitor venetoclax. Although it is evident that this unique sensitivity venetoclax depends on Bcl-2 homology domain 3- proapoptotic protein priming BCL2, biology underlying dependency poorly defined. Importantly, epigenetic regulation transcriptomes its impact gene clinical response remain elusive. In study,...
<b><i>Objective:</i></b> The aim of this study was to apply a semi-automated calculation method fetal body volume and, thus, magnetic resonance-estimated weight (MR-EFW) prior planned delivery and evaluate whether the technique measurement could be simplified while remaining accurate. <b><i>Methods: </i></b>MR-EFW calculated using at 38.6 weeks gestation in 36 patients compared picture archiving communication system (PACS). Per patient, 8...
The magnetic resonance imaging (MRI) appearance of an "established" bone marrow infarct is well-known, consisting area preserved signal surrounded by a serpiginous line. We report the uncommon observation very early phases infarct, showing its progressive de novo on MR images paralleling clinical symptoms and high-dose systemic steroid administration in young female patient, presenting with acute knee pain. initial examination performed one week after pain onset showed no abnormality. One...
The goal of this study is to systematically evaluate the magnetic resonance imaging (MRI) signal characteristics and size cataracts that may be encountered in pediatric young adult patients.A retrospective analysis MRI features with a series cases, including characterization intensity on T2-weighted T1-weighted sequences, as well measuring thickness lens.Among nine seven patients, three lenses were thickened hyperintense presumably related osmotic effects. rest either normal characteristics,...
After insemination, a subpopulation of sperm reaches the oviducts and binds to isthmic epithelial cells form "sperm reservoir". Our objective was explore role annexin A5 (ANXA5), protein that with high affinity phosphatidylserine (PS), in formation reservoir pigs. Phosphatidylserine detected on head approximately 10 % boar at ejaculation. Porcine ANXA5 immunodetected strong signal luminal cilia isthmus derived spheroids (IES). Exogenous PS between 0.01 0.1 µg/mL recombinant porcine (rpANXA5)...
Our purpose was to retrospectively evaluate the safety and efficacy of transarterial hepatic radioembolization (TARE) treatment with yttrium-90 labeled glass microspheres in patients chemotherapy-refractory breast cancer liver-dominant metastatic disease.This retrospective single-institution study evaluated 31 female (mean age 59.6 ± 13.2 years) who were treated TARE. All received progressed on systemic chemotherapy before Twenty-one also had extrahepatic metastases, including 13 metastases...
The Effect of Hydraulic Vibrations on Initiation Buckling and Axial Force Transfer for Helically Buckled Pipes at Simulated Horizontal Wellbore Conditions Elie R. Barakat; Barakat Chevron Search other works by this author on: This Site Google Scholar Stefan Z. Miska; Miska U. Tulsa Mengjiao Yu; Yu Petru-Aurelian Simionescu; Simionescu University Nicholas E. Takach Paper presented the SPE/IADC Drilling Conference, Amsterdam, Netherlands, February 2007. Number: SPE-105123-MS...
We describe a simple ultrasound (US)-guided technique for accurate anatomical right atrium localization prior to permanent hemodialysis catheter insertion. It is used in patients whom will be inserted through an internal jugular vein access, order have the functional tip located at mid-level of atrium. In this technique, localized on US via left intercostal approach insertion under fluoroscopic guidance.
This paper presents a study and design of monitoring system for the continuous measurement electrical energy parameters such as voltage, current, power temperature. is designed to monitor data remotely over internet. The electronic meter based on microcontroller from Microchip Technology Inc. PIC family. takes into consideration correct operation in event an outage or brown out by recording values temperatures EEPROM internally available microcontroller. Also digital display used show...