A series of urea and thiourea derivatives s-triazine have been developed based on high yielding nucleophilic substitution 2,4,6-trichloro-1,3,5-triazine by 4-hydroxy coumarin, cyclopropylamine ammonia at suitable conditions.These were further treated with various substituted aryl isocyanate isothiocyanate.All the synthesized compounds evaluated for their antibacterial activities against Gram-positive Gram-negative strains bacteria.A few showed good to superior in vitro activity S.aureus,...

In an effort to discover new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evalution of various series 2-(N-methylamino)-4-(N,N-dimethylamino)-6-(arylthioureido)-s-triazine (5a–j) (N-methylamino)-4-(N,N-dimethylamino)-6-(arylureido)-s-triazine (6a–j). All synthesized compounds were screened for their antibacterial activity against two different gram-positive bacteria (S. aureus, B. subtilis) gram-negative (P. aeruginosa, E. coli) using...

Streptococcal toxic shock syndrome (TSS) is a fulminant disease characterised by rapid progression to multiorgan failure. However, streptococcal TSS manifesting as uterine necrosis (UN) unusual. Here, we present case of woman in her 30s with constellation symptoms, including abdominal pain, fatigue and fever. Despite an initially unclear clinical picture, she rapidly developed radiographical evidence intrabdominal arterial narrowing spurious infarctions ischaemic colitis. Exploratory...

Satellite communication systems operating at Ka band and Ku frequencies must affect the problem of propagation impairments which includes fading due to rain, clouds, snow for obtaining required performance.Rain affects signal most involved is absorption & scattering.Auto-Regressive Integrated Moving Average (ARIMA) model used generate predict time series values rain attenuation.The predicted obtained different window size ARIMA analysis done in terms error matrix

Integration of the renewable source in existing distribution network under varying load profile is a daunting task. This paper presents active power control PV system. availability and demand are mismatching. The extraction maximum enhanced with Perturb & Observe algorithm. In this Maximum Power Point Tracking (MPPT) algorithm coordinated Constant Generation (CPG) to address high penetration issue. implemented MATLAB Simulink environment. efficacy proposed technique tested for...

Abstract: In the current investigation, some newer triazines merged benzothiazole hybrids were subjected to molecular properties prediction, drug-likeness, lipophilicity and solubility parameters determination using Molinspiration, Molsoft ALOGPS 2.1 softwares. Amongst ten proposed analogues only seven therapeutic candidates chosen on basis of Lipinski’s “Rule Five”. Selected title compounds synthesized by cyclizing 3-chloroaniline potassium thiocyanate in presence bromine yielded...

The aim of the present investigation is to develop a stable formulation for Self-Nanoemulsifying Drug Delivery System (SNEDDS) in order enhance solubility and release rate poorly soluble drug (felodipine). Solubility study was performed select oil, surfactant co which had highest solubility. pseudo-ternary phase diagram constructed effect change ratio surfactant/co-surfactant on nanoemulsion find emulsification area diagram. simplex lattice design used optimize each evaluated various...

Growing the use of nonlinear devices for purpose controlling machines as per our definition. These circuits are based on power semiconductor switching which most harmonic source in network. Due to negative effect harmonics, filtration it must require. The active filter is superior solution eliminating unwanted harmonics. This paper will speak and discuss simulation its result a 3-phase 3-wire shunt with MATLAB/Simulink software. implement non-linear load compensate line current harmonics...

Aim: Brexpiprazole (BPZ) is a typical antipsychotic drug used for the treatment of schizophrenia and depression. It classified under BCS class-II with low aqueous solubility high intestinal permeability. In present investigation, solid dispersion BPZ was prepared to improve solubility. A transdermal patch optimized using central composite design control delivery BPZ.
 Place Duration Study: The formulation characterized at K. B. Institute Pharmaceutical Education Research, Gandhinagar,...

Offshore, bridges, steel structures, and heavy-duty equipment all use hollow cantilever beams. The great challenge for design engineers is to provide a better robust of beam that can withstand applied load with optimized parameters. According the literature review, strengthening or plate be accomplished by providing transversal and/or longitudinal stiffeners post-buckling lateral buckling moments. Thus, it not sufficient designers only part component minimum weight cost while ensuring...