A5044501042- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Connective tissue disorders research
- Probiotics and Fermented Foods
- Bacterial Infections and Vaccines
- Fibroblast Growth Factor Research
- Genomics and Phylogenetic Studies
- Infectious Diseases and Mycology
- Mycotoxins in Agriculture and Food
- Genetic Syndromes and Imprinting
- Plant Disease Resistance and Genetics
University of Minnesota
2021-2024
University of Minnesota Medical Center
2023
Drug resistant Candida auris infections are recognized by the CDC as an urgent threat. Here, we obtained and characterized a set of clinical isolates C. including multiple from same patient.
Invasive fungal infections are a leading global cause of human mortality. Only three major classes antifungal drugs widely used, and resistance to all can arise rapidly. The most prescribed drug, fluconazole, disseminates rapidly reaches wide range concentrations throughout the body. impact drug concentration on spectrum effect mutations acquired during adaptation is not known for any pathogen, how specific level given stress influences distribution beneficial has been poorly explored in...
The human fungal pathogen Candida albicans poses a significant burden on global health, causing high rates of mortality and antifungal drug resistance. C. is heterozygous diploid organism that reproduces asexually. Structural variants (SVs) are an important source genomic rearrangement, particularly in species lack sexual recombination. To comprehensively investigate SVs across clinical isolates , we conducted long read sequencing genome-wide SV analysis three distantly related isolates. Our...
A delicate balance between genome stability and instability ensures integrity while generating genetic diversity, a critical step for evolution. Indeed, excessive is harmful, moderated can drive adaptation to novel environments by maximising variation. Candida albicans , human fungal pathogen that colonises different parts of the body, adapts rapidly frequently hostile host microenvironments. In this organism, ability generate large-scale genomic variation key adaptative mechanism triggering...
Abstract Antifungal drug resistance and tolerance poses a serious threat to global public health. In the human fungal pathogen, Candida auris , triazole, polyene, echinocandin antifungals is rising, resulting in multidrug resistant isolates. Here, we use genome analysis vitro evolution of seventeen new clinical isolates C. from clades I IV determine how quickly mutations arise, stability absence drug, impact genetic background on evolutionary trajectories. We evolved each isolate as well low...
Abstract Stress-induced genome instability in microbial organisms is emerging as a critical regulatory mechanism for driving rapid and reversible adaption to drastic environmental changes. In Candida albicans , human fungal pathogen that causes life-threatening infections, plasticity confers increased virulence antifungal drug resistance. Discovering the mechanisms regulating C. priority understand how this other pathogens establish infections develop resistance drugs. We identified SUMO...