A5047089457- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Biochemical Acid Research Studies
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Crustacean biology and ecology
- Mosquito-borne diseases and control
- Ubiquitin and proteasome pathways
- Neuroscience and Neuropharmacology Research
- Physiological and biochemical adaptations
- Bioactive Compounds and Antitumor Agents
- Biochemical and Molecular Research
Semmelweis University
2015-2022
Montavid Thermodynamic Research Group
2016-2017
Hungarian Academy of Sciences
2015
Itaconate is a nonamino organic acid exhibiting antimicrobial effects. It has been recently identified in cells of macrophage lineage as product an enzyme encoded by immunoresponsive gene 1 (Irg1), acting on the citric cycle intermediate cis-aconitate. In mitochondria, itaconate can be converted succinate-coenzyme A (CoA) ligase to itaconyl-CoA at expense ATP (or GTP), and also weak competitive inhibitor complex II. Here, we investigated specific bioenergetic effects increased production...
Succinate-CoA ligase (SUCL) is a heterodimer enzyme composed of Suclg1 α-subunit and substrate-specific Sucla2 or Suclg2 β-subunit yielding ATP GTP, respectively. In humans, the deficiency this leads to encephalomyopathy with without methylmalonyl aciduria, in addition resulting mitochondrial DNA depletion. We generated mice lacking either one allele. heterozygote exhibited tissue- age-dependent decreases expression associated ATP-forming activity, but rebound increases cardiac GTP-forming...
α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been identified neurodegenerative diseases such as Alzheimer's disease. The aim of present study was to establish role KGDHc and its subunits bioenergetics reactive oxygen species (ROS) homeostasis brain mitochondria. To bioenergetic profile KGDHc, genetically modified mouse strains were used having heterozygous knock out (KO) either dihydrolipoyl...