A5091533519- Non-Invasive Vital Sign Monitoring
- Palliative Care and End-of-Life Issues
- Phonocardiography and Auscultation Techniques
- Healthcare Technology and Patient Monitoring
- ECG Monitoring and Analysis
- Neurogenesis and neuroplasticity mechanisms
- Social and Demographic Issues in Germany
- Health and Medical Studies
- Patient Dignity and Privacy
- Hemodynamic Monitoring and Therapy
- Ethics in medical practice
- Psychosomatic Disorders and Their Treatments
- Information Systems Theories and Implementation
- Innovative Approaches in Technology and Social Development
- Nerve injury and regeneration
- Acute Ischemic Stroke Management
- Indoor and Outdoor Localization Technologies
- Social Policies and Healthcare Reform
- Childhood Cancer Survivors' Quality of Life
- Advanced Chemical Sensor Technologies
- Music Therapy and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Management and Placebo Effect
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Rate Variability and Autonomic Control
Comprehensive Cancer Center Erlangen
2013-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013-2025
Universitätsklinikum Erlangen
2016-2025
Siemens (Germany)
2023
GTx (United States)
2013
University of Münster
2005-2007
Johannes Gutenberg University Mainz
2007
Expedeon (Germany)
2007
University of Gothenburg
2005
Heidelberg University
2005
G-CSF is a potent hematopoietic factor that enhances survival and drives differentiation of myeloid lineage cells, resulting in the generation neutrophilic granulocytes. Here, we show passes intact blood-brain barrier reduces infarct volume 2 different rat models acute stroke. displays strong anti-apoptotic activity mature neurons activates multiple cell pathways. Both its receptor are widely expressed by CNS, their expression induced ischemia, which suggests an autocrine protective...
The discovery of spontaneous neuronal replacement in the adult brain has shifted experimental stroke therapies toward a combined approach preventing cell death and inducing plasticity. Brain-derived neurotrophic factor (BDNF) was shown to induce antiapoptotic mechanisms after reduce infarct size secondary death. Moreover, intact animals, BDNF is potent stimulator neurogenesis.The current study analyzed effects on induction progenitor migration sensorimotor recovery cortical photothrombotic...
Abstract This paper introduces heart sound detection by radar systems, which enables touch-free and continuous monitoring of sounds. The proposed measurement principle entails two enhancements in modern vital sign monitoring. First, common touch-based auscultation with a phonocardiograph can be simplified using biomedical systems. Second, detecting sounds offers further feasibility radar-based heartbeat To analyse the performance principle, 9930 seconds eleven persons-under-tests’ signs were...
Abstract Using Radar it is possible to measure vital signs through clothing or a mattress from the distance. This allows for very comfortable way of continuous monitoring in hospitals home environments. The dataset presented this article consists 24 h synchronised data radar and reference device. implemented wave system based on Six-Port technology operates at GHz ISM band. device simultaneously measures electrocardiogram, impedance cardiogram non-invasive blood pressure. 30 healthy subjects...
To study the safety and effects of early continuous hypertonic saline infusion in patients with cerebral edema underlying cerebrovascular disease.Retrospective analysis.University medical center.Neurologic intensive care unit population mixed diseases.None.Between May 2008 December 2009, 100 severe intracerebral hemorrhage, ischemia, or aneurysmal subarachnoid hemorrhage signs intracranial hypertension received within ≤72 hrs after symptom onset a (3%, target sodium 145-155 mmol/L,...
Objective: Radar technology promises to be a touchless and thereby burden-free method for continuous heart sound monitoring, which can used detect cardiovascular diseases. However, the first most crucial step is differentiate between high- low-quality segments in recording assess their suitability subsequent automated analysis. This paper gives comprehensive study on this task addresses specific characteristics of radar-recorded signals. Methods: To gather signals recorded from radar,...
Abstract Radar systems allow for contactless measurements of vital signs such as heart sounds, the pulse signal, and respiration. This approach is able to tackle crucial disadvantages state-of-the-art monitoring devices need permanent wiring skin contact. Potential applications include employment in a hospital environment but also home care or passenger vehicles. dataset consists synchronised data which are acquired using Six-Port-based radar system operating at 24 GHz, digital stethoscope,...
Contactless measurement of heart rate variability (HRV), which reflects changes the autonomic nervous system (ANS) and provides crucial information on health status a person, would provide great benefits for both patients doctors during prevention aftercare. However, gold standard devices to record HRV, such as electrocardiograph, have common disadvantage that they need permanent skin contact with patient. Being connected monitoring device by cable reduces mobility, comfort, compliance...
Neuroprotective effects of induced hypothermia depend on its time point initiation after acute brain injury. Preliminary studies in cardiac arrest patients indicate that rapid infusion ice cold saline (ICS) is safe and effective for induction hypothermia. We investigated use with ischemic stroke (AIS).Patients (n=10) AIS were included within 3 hours symptom onset. After cranial CT, they treated-if indicated-with rt-PA. ICS 4 degrees C (25 mL/kg body weight) was administered via peripheral...
Although a lot of research has been done into radar-based heartbeat detection over the past few years, it is still unknown which physiological effects truly underlie these measurement signals. This paper investigates cardiovascular system, as well due to antenna characteristics, and establishes connection variety signals that can be found in comparable publications. For first time, cause diverging signal shapes researched, revealing locally specific pulse wave curves named sphygmograms....
While adult neurogenesis is considered to be restricted the hippocampal dentate gyrus (DG) and subventricular zone (SVZ), recent studies in humans rodents provide evidence for newly generated neurons regions generally as non-neurogenic, e.g. striatum. Stimulating dopaminergic neurotransmission has potential enhance SVZ DG most likely via D2/D3 dopamine (DA) receptors. Here, we investigated effect of two distinct preferential DA agonists, Pramipexole (PPX) Ropinirole (ROP), on hippocampus...
Vital parameters are key indicators for the assessment of health. Conventional methods rely on direct contact with patients' skin and can hence cause discomfort reduce autonomy. This article presents a bistatic 24 GHz radar system based an interferometric six-port architecture features precision 1 µm in distance measurements. Placed at 40 cm front human chest, it detects vibrations containing respiratory movements, pulse waves heart sounds. For extraction respiration rate, time-domain...
Monitoring the propagation of mechanical cardiac signals throughout body is crucial for assessing cardiovascular health. A common drawback current gold standard methods vital sign monitoring necessity continuous skin contact. Radar-based sensing offers a promising alternative by enabling contactless measurement activity, including heart sound signals. As previous research has primarily focused on deriving from proximal regions, insights into to peripheral areas are lacking. To address this,...
Context: Palliative care prioritizes patients' quality of life with symptom management, personal care, and minimal technology use to respect privacy. However, assessing symptoms, particularly for patients near the end who often are unable communicate, mostly depends on observation by healthcare providers, which may lack completeness objectivity. Objectives: Non-invasive radar-based monitoring heart rate (HR) respiration (RR) offers potential detecting symptoms without compromising palliative...
Palliative care is based on the principle of multi-professional collaboration, which integrates diverse competencies and perspectives to provide holistic support for patients their relatives. In palliative teams, there an intensive exchange information knowledge; however, current documentation hospital systems often fall short meeting specific demands effective collaboration dynamic communication in this field. This action design research study three-and-a-half-year interdisciplinary project...
Zusammenfassung In der Palliativversorgung werden technische Hilfsmittel wie EKG oder Pulsoxymetrie nur sparsam eingesetzt, um Zuwendung und Beziehungsarbeit nicht zu stören. Gleichzeitig ist Symptomerkennung essenziell viele Patient*innen können diese selbst äußern. Diese Studie untersucht erstmals den Einsatz eines Radarsystems zum berührungslosen Atemfrequenzmonitoring bei Palliativpatient*innen. einer prospektiven wurde radarbasiertes mit Goldstandardmethode stationär behandelten...
<title>Abstract</title> <bold>Background</bold> Electronichealth applications are playing an increasingly significant role in modern healthcare systems. Therefore, the European Union proposed GAIA -X - a digital ecosystem that facilitates data exchange and sovereign usage. TEAM-X aims to implement healthcare, this study focuses on palliative care. Especially vulnerable context, identifying opinions of prospective users during development ensures their needs as well objectives principles care...
<title>Abstract</title> Background The use of digital health technologies holds potential benefits for palliative care. Their implementation is fundamentally shifting routines and care practices. These shifts entail social implications that are complex, may emerge gradually challenging to identify. However, the not conceptualized yet. This study addresses this gap by developing a framework on in care, where importance inclusion interpersonal connection particularly evident. Methods We...
Cardiac auscultation provides an efficient and costeffective way for cardiac disease pre-screening.The George B. Moody PhysioNet Challenge 2022 aimed to detect heart murmurs clinical outcomes with sound recordings from multiple locations.Our team HearHeart proposed a lightweight convolutional neural network (CNN) random forest model classify outcomes.128 Melspectrogram features wide like the sociodemographic data statistical are extracted.Different techniques employed migrate imbalance...
Abstract Background Heart rate (HR) monitoring is a medical standard to provide information about patient’s health status. In palliative care, relationship and social engagement are crucial therapeutic concepts. For fear of disrupting communication, contact, continuous HR underutilised despite its potential inform on symptom burden effects. This study investigates radar-based as an innovative burden-free approach for care patients, compares accuracy with conventional ECG methods, shows...