A5101792679- Iron Metabolism and Disorders
- Genomics and Chromatin Dynamics
- Complement system in diseases
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Cancer, Hypoxia, and Metabolism
- Fungal Infections and Studies
- Hemoglobinopathies and Related Disorders
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Renal Diseases and Glomerulopathies
- Rough Sets and Fuzzy Logic
- HIV/AIDS drug development and treatment
- DNA and Nucleic Acid Chemistry
- Biochemical and Molecular Research
- Nitric Oxide and Endothelin Effects
- Antifungal resistance and susceptibility
- semigroups and automata theory
- Erythropoietin and Anemia Treatment
- Cancer therapeutics and mechanisms
- HIV Research and Treatment
- Advanced Algebra and Logic
Washington University in St. Louis
2019-2025
Novartis (United States)
2019
University of Pittsburgh
2014-2017
Oxford University Clinical Research Unit
2013
University of Houston
2005
Non-degradative histone ubiquitylation plays a myriad of well-defined roles in the regulation gene expression and choreographing DNA damage repair pathways. In contrast, contributions degradative on genomic processes has remained elusive. Recently, APC/C been shown to ubiquitylate histones regulate pluripotent cells, but molecular mechanism is unclear. Here we show that despite directly binding nucleosome through subunit APC3, unable nucleosomal histones. extranucleosomal H2A/H2B H3/H4...
The mechanism by which HIV-1 reverse transcriptase (HIV-RT) discriminates between the correct and incorrect nucleotide is not clearly understood. Chemically modified nucleotides containing 1-aminonaphthalene-5-sulfonate (ANS) attached to their γ-phosphate were synthesized used probe selection this error prone polymerase. Primer extension reactions provide direct evidence that polymerase able incorporate gamma-modified nucleotides. Forward mutation assays reveal a 6-fold reduction in...
Iron is a critical component of metabolic homeostasis, but consumption dietary iron has increased dramatically in the last 30 years, corresponding with rise disease. While link between metabolism and health well established, extent to which contributes disease risk unexplored. Further, it unknown how interacts genetic background modify risk.
Oxidized soluble guanylate cyclase (sGC) heme iron (Fe 3+ ) is desensitized to nitric oxide (NO) and attenuates cGMP production needed for downstream activation of PKG-dependent signaling vasodilation. While reactive oxygen species drive oxidation sGC iron, the basic mechanism(s) governing recycling its NO-sensitive, reduced state 2+ ), are unknown. Here we report cytochrome b5 reductase 3 (Cyb5R3), also known as methemoglobin reductase, a novel regulator in vascular smooth muscle cells...