A5025849470- Genetic and Kidney Cyst Diseases
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Renal and related cancers
- Epigenetics and DNA Methylation
- Fish Ecology and Management Studies
- Sperm and Testicular Function
- Reproductive biology and impacts on aquatic species
Hebrew University of Jerusalem
2021-2023
Jerusalem Institute for Israel Studies
2023
University of California, Davis
2020
A hallmark of meiosis is chromosomal pairing, which requires telomere tethering and rotation on the nuclear envelope through microtubules, driving chromosome homology searches. Telomere pulling toward centrosome forms "zygotene bouquet." Here, we identified cilium" in oocytes. This cilium provides a cable system for bouquet machinery extends throughout germline cyst. Using zebrafish mutants live manipulations, demonstrate that anchors to counterbalance pulling. The essential synaptonemal...
The longevity of sperm in teleost such as zebrafish and medaka is short when isolated even saline-balanced solution at a physiological temperature. In contrast, some internal fertilizers exhibit the long-term storage sperm, >10 months, female reproductive tract. This evidence implies that possesses ability to survive for long time under suitable conditions; however, these conditions are not well understood. this study, we show can maintain fertility L-15-based medium supplemented with bovine...
Abstract The hallmark of meiosis is chromosomal pairing and synapsis via synaptonemal complexes, but also depends on cytoplasmic counterparts that tether rotate telomeres the nuclear envelope. Telomeres slide perinuclear microtubules, shuffling chromosomes mechanically driving their homology searches. Pull towards centrosome drives formation “zygotene bouquet”. These telomere dynamics are essential for fertility, bouquet, discovered in 1900, universally conserved. Nevertheless, how bouquet...
Abstract FGF signaling is used reiteratively during development and elicits several different responses, such as cell proliferation, differentiation, or migration. We parsed the complex intracellular response by creating triple homozygous mutants in Pea3 subgroup of ETS transcription factors, designated 3etv mutants. The proteins Etv4 Etv5 are expressed areas activity; however, their role signal transduction either positive negative modulators activity was unclear. Using mutants, we found...