A5068514015- Epigenetics and DNA Methylation
- Recycling and Waste Management Techniques
- Renal and related cancers
- Effects and risks of endocrine disrupting chemicals
- Reproductive Biology and Fertility
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Microplastics and Plastic Pollution
Ministry of Agriculture, Livestock, and Food Supply
2022-2023
Northwest A&F University
2022-2023
Extensive epigenetic reprogramming occurs during preimplantation embryonic development. However, the impact of DNA methylation in plateau yak embryos and how contributes to transcriptional regulatory networks are unclear. In this study, we quantified gene expression oocytes a series at different developmental stages single-cell resolution using bisulfate-sequencing RNA-seq. We characterized genome activation maternal transcript degradation mapped events critical for Through cross-species...
Aberrant epigenetic nuclear reprogramming, especially imprinting pattern disorders, is one of the major causes failure clone development from somatic cell transfer (SCNT). Previous studies showed that ZFP57 a key protein required for imprint maintenance after fertilization. In this study, we found control regions in several imprinted genes were significantly hypomethylated cloned embryos compared with vitro fertilization embryos, indicating loss gene methylation. The expression was capable...