A5028415031- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- IL-33, ST2, and ILC Pathways
- Occupational exposure and asthma
- Drug-Induced Adverse Reactions
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
Ajou University
2017-2025
Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial involved in the regulation of immune responses. Degradation PAF by acetylhydrolase (PAF-AH) has been shown to be associated with anaphylaxis, asthma, peanut allergy. The purpose this study was investigate relationships among clinical parameters, including urticaria severity treatment responsiveness, PAF-AH levels sera patients chronic spontaneous (CSU). Serum...
Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by itchy wheals of at least 6 weeks in duration, wherein the autoimmune mechanism involved to activate IgE receptors (FcεRIα) on mast cells. We aimed assess levels IgG autoantibody against FcεRIα sera from CSU patients using dot-blot immunoassay. performed hospital-based cross-sectional study 125 (64 ASST-positive, 61 ASST-negative) and 64 age-and sex-matched healthy controls. The cut-off value was determined as mean...
Shrimp is a predominant allergic food in adults and adolescents. This study aims to evaluate the clinical efficacy of immunologic diagnosis differentiating phenotypes shrimp allergy. We enrolled 85 diagnosed with allergy based on symptoms that occurred at least twice after ingestion who had specific immunoglobulin E (IgE) results for extract, were study. Patients classified into 2 groups: anaphylaxis (ANA) non-ANA. Serum-specific IgEs recombinant tropomyosin from both house dust mite (HDM)...
Asthma in the elderly has different clinical features including more severe phenotypes with higher comorbidities. Epithelial cells are known to initiate innate/adaptive immune responses asthmatic airways. We investigated and epithelial derived cytokine levels asthmatics compared non-elderly a cross-sectional cohort of adult order further understand its pathogenic mechanisms.A total 1,452 were enrolled from single tertiary hospital classified into 2 groups: 234 (≥ 60 years at initial...
Translationally controlled tumor protein (TCTP) is also known as histamine releasing factor it has the ability to activate mast cells. To investigate role of TCTP in pathogenesis chronic spontaneous urticaria (CSU), we evaluated serum level and effect on basophil cell degranulation. levels sera from 116 CSU patients 70 normal healthy controls (NCs) were measured by ELISA. CD203c expression basophils β-hexosaminidase release Laboratory Allergic Disease 2 cells upon stimulation monomeric...
BackgroundIn baker's asthma previous studies suggest that adaptive and innate immunity are involved in the development of work-related respiratory symptoms (WRS), where we hypothesized epithelial cells derive airway inflammation through modulating release inflammatory cytokines. Thus, conducted this study to investigate role cell-derived cytokines WRS among bakery workers.MethodsWe recruited 385 wheat-exposed subjects with (WRS+)/without (WRS-) working a single industry 243 unexposed...
This work was supported by a grant from the National Research Foundation of Korea (NRF) funded government (MSIP) (NRF-2018R1A2B6006199) and research Ahn-Gook Pharmaceutical Co, Ltd, Seoul, Republic Korea. Platelet activating factor (PAF) is one most potent phospholipid released platelets as well various inflammatory cells. PAF has been known to play role in regulation immune responses allergic inflammation. study aimed compare circulating levels PAF-acetylhydrolase (AH) which can catabolize...