A5083618412- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Pain Mechanisms and Treatments
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease and Transplantation
- Pharmacological Effects of Natural Compounds
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Spine and Intervertebral Disc Pathology
- Liver Disease Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Magnesium in Health and Disease
- Neurological Disease Mechanisms and Treatments
- Ginseng Biological Effects and Applications
- Renal Diseases and Glomerulopathies
- Immune Response and Inflammation
- Anesthesia and Pain Management
- Gastric Cancer Management and Outcomes
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Acupuncture Treatment Research Studies
- Ion Channels and Receptors
- Orthopaedic implants and arthroplasty
Kyung Hee University
2015-2024
Samsung Medical Center
2020
Yonsei University
2017-2019
Yonsei University Health System
2015-2018
Severance Hospital
2017-2018
To evaluate the predictive and prognostic significance of nutritional index (PNI) in a large cohort gastric cancer patients who underwent gastrectomy. Assessing patient's immune status, PNI has been reported as marker for surgical outcomes various types cancer. We retrospectively reviewed data from prospectively maintained database 7781 gastrectomy January 2001 to December 2010 at single center. From this data, we analyzed clinicopathologic characteristics, PNI, short- long-term each...
Abstract Dysregulation of the immune system contributes to pathogenesis neuropsychiatric disorders including schizophrenia. Here, we demonstrated that toll-like receptor (TLR)-2, a family pattern-recognition receptors, is involved in schizophrenia-like symptoms. Psychotic symptoms such as hyperlocomotion, anxiolytic-like behaviors, prepulse inhibition deficits, social withdrawal and cognitive impairments were observed TLR-2 knock-out (KO) mice. Ventricle enlargement, hallmark schizophrenia,...
Abstract Inflammation and oxidative stress play major roles in the pathogenesis after spinal cord injury (SCI). Here, we examined neuroprotective effects of Angelica dahuricae radix (ADR) extract SCI. ADR significantly decreased levels proinflammatory factors such as tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), inducible nitric oxide synthase (iNOS), cyclooxygenase‐2 (COX‐2) a lipopolysaccharide (LPS)‐activated microglial cell line, BV2 cells. also...
It has been shown that epigenetic regulation plays an important role in skin wound healing. We previously found histone H3K27me3 demethylase JMJD3 regulates inflammation and cell migration keratinocyte In this study, we identified Notch1 as a direct target of NF-κB wounded keratinocytes using vitro vivo animal models. is up-regulated the edge its expression dependent on keratinocytes. also activates RhoU PLAU gene, which are critical regulators migration. Consistently, depletion or...
The blood-brain barrier (BBB) or blood-spinal cord (BSCB) formed by capillary endothelial cells provides a physical wall between the central nervous system (CNS) and circulating blood with highly selective permeability. BBB/BSCB disruption activation of matrix metalloproteinases (MMPs) has been shown to result in further neurological damage after CNS injury. Recently it discovered that estrogen attenuates vitro vivo models. However, molecular mechanism underlying estrogen-mediated...
The inflammatory response contributes substantially to secondary injury cascades after spinal cord injury, with both neurotoxic and protective effects. However, epigenetic regulations of genes following have yet be characterized thoroughly. In this study, we found that histone H3K27me3 demethylase Jmjd3 expression is acutely up-regulated in blood vessels the injured cord. We also observed up-regulation gene bEnd.3 endothelial cells were subjected oxygen-glucose deprivation/reperfusion...
Recently, we reported the antiapoptotic effect of ghrelin in spinal cord injury-induced apoptotic cell death oligodendrocytes. However, how inhibits oligodendrocytes apoptosis, is still unknown. Therefore, present study, examined whether microglia activation and thereby oligodendrocyte apoptosis.Using total extracts prepared from BV-2 cells activated by lipopolysaccharide (LPS) with or without ghrelin, levels p-p38 phosphor-p38 mitogen-activated protein kinase (p-p38MAPK), phospho-c-Jun...
After spinal cord injury (SCI), blood-spinal barrier (BSCB) disruption results in secondary including apoptotic cell death of neurons and oligodendrocytes, thereby leads to permanent neurological deficits. Recently, we reported that the histone H3K27me3 demethylase Jmjd3 plays a role regulating BSCB integrity after SCI. Here, investigated whether gallic acid (GA), natural phenolic compound is known be anti-inflammatory, regulates expression activation, attenuates following inflammatory...
Diabetic neuropathy is one of the most devastating ailments peripheral nervous system. Neuropathic pain develops in ∼30% diabetics. Here, we examined suppressive effect GS-KG9 on neuropathic induced by streptozotocin (STZ).Hyperglycemia was intraperitoneal injection STZ. Rats showing blood glucose level > 250 mg/dL were divided into five groups, and treatment groups received oral saline containing (50 mg/kg, 150 or 300 mg/kg) twice daily for 4 wk. The effects behavior, microglia activation...
The effect of delayed graft function (DGF) recovery on long-term outcome is unclear. aim this study was to examine the association DGF status with outcome. We analyzed 385 recipients who underwent single kidney transplantation from brain-dead donors between 2004 and 2015. Patients were grouped according renal at 1 month post-transplantation: control (without DGF); recovered (glomerular filtration rate [GFR] ≥ 30 mL/min/1.73 m2); incompletely group (GFR < m2). occurred in 104 (27%)...
In this study, we investigated whether total saponin extract (TSE), ginsenoside Rb1, and Rb1 metabolite compound K, which are isolated from red ginseng, have antinociceptive effects on peripheral central neuropathic pain (PNP CNP, respectively). PNP CNP were induced by tail nerve injury (TNI) at S1 contusive spinal cord (SCI) T9 in male Sprague–Dawley rats, respectively. Two weeks after TNI or 4 SCI, pain‐induced rats orally administered vehicle, TSE (50 mg/kg), (12.5 K (7 gabapentin (GBP,...
Abstract This retrospective study evaluated lactate clearance ( LC ), measured at 6, 12, 18, and 24 hours after reperfusion, as a predictor of early allograft dysfunction EAD ) short‐term outcomes in patients receiving deceased donor liver transplantation. Of 181 transplant recipients, 44 (24.3%) developed had lower s than those who did not develop . A receiver operating characteristic analysis showed that determined 6 the highest area under curve value 0.828 (95% confidence interval [ CI ]:...
Sensitized patients received desensitization therapy with rituximab for kidney transplantation. However, the impact of dose on hepatitis B virus (HBV) reactivation is unknown. Patients who underwent living donor transplantation between 2008 and 2016 were grouped according to (control vs. standard-dose [375 mg/m2] reduced-dose [200 mg/body]) comparison HBV reactivation. A total 336 surface antigen (HBsAg)-negative/antibody core (anti-HBc)-positive transplantation, whom 91 (27.1%) (57 34...
The tumor suppressor CYLD is a deubiquitinating enzyme that inhibits activation of the NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>κ</mml:mi></mml:math>B, which has key roles in inflammation and apoptosis. We hypothesized may regulate xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>κ</mml:mi></mml:math>B signaling pathway cholesteatoma. conducted immunohistochemistry to examine expression 16 cases cholesteatoma paired retroauricular (RA) skin. In epithelium,...
Histologic analysis of the ligamentum flavum (LF) in lumbar spine.The objective this study is to investigate levels glycogen synthase kinase-3β (GSK-3β) and β-catenin LF tissue patients with spinal stenosis (LSS).The hypertrophy primary cause progression LSS. Recently, Wnt signaling has been proposed as one molecular processes contributing hypertrophy. GSK-3β are recognized play a crucial part control pathway.From May 2020 July 2022, from 51 LSS (LSS group) 18 disc herniation (control were...