A5102909860- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Immune Response and Inflammation
- Developmental Biology and Gene Regulation
- Advanced Glycation End Products research
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
Hunan University
2021-2023
Tumor angiogenesis plays a crucial role in colorectal cancer development. Dysregulation of the receptor for advanced glycation end-products (RAGE) transmembrane signaling mediates inflammation, resulting various cancers. However, mechanism RAGE pathway modulating development has not been explored. In this study, an aptamer-based antagonist (Apt-RAGE) was used to inhibit interaction between and S100B, thus blocking downstream NFκB-mediated signal transduction. vitro results showed that...
Abstract Neural progenitor cells (NPCs) are essential for in vitro drug screening and cell-based therapies brain-related disorders, necessitating well-defined reproducible culture systems. Current strategies employing protein growth factors pose challenges terms of both reproducibility cost. In this study, we developed a novel DNA-based modulator to regulate FGFR signaling NPCs, thereby facilitating the long-term maintenance stemness promoting neurogenesis. This FGFR-agonist effectively...
Abstract Neural progenitor cells (NPCs) are important for in vitro drug screening and the cell-based therapy brain-related disorders, which requires well-defined reproducible culture systems. Current strategy use of protein growth factors presents challenges terms reproducibility cost. In this study, we have developed a novel DNA-based modulator to regulate FGFR signaling NPCs, enabling maintenance stemness over 50 passages neurogenesis towards neurons. The FGFR-agonist effectively promoted...