Lisa M. Schaefbauer
- Cell Image Analysis Techniques
- Genetics, Bioinformatics, and Biomedical Research
- Advanced Fluorescence Microscopy Techniques
- Scientific Computing and Data Management
- Cellular Mechanics and Interactions
- Single-cell and spatial transcriptomics
- 3D Printing in Biomedical Research
Allen Institute for Cell Science
2020-2023
Understanding how a subset of expressed genes dictates cellular phenotype is considerable challenge owing to the large numbers molecules involved, their combinatorics and plethora behaviours that they determine
Summary Despite the intimate link between cell organization and function, principles underlying intracellular relation organization, gene expression phenotype are not well understood. We address this by creating a benchmark for mean natural range of cell-to-cell variation. This can be used comparison to other normal or abnormal states. To do this, we developed reproducible microscope imaging pipeline generate high-quality dataset 3D, high-resolution images over 200,000 live cells from 25...