A5108034554- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Resilience and Mental Health
- Bone fractures and treatments
- Estrogen and related hormone effects
- Pelvic and Acetabular Injuries
- Emergency and Acute Care Studies
- Lower Extremity Biomechanics and Pathologies
- Pacific and Southeast Asian Studies
- COVID-19 and healthcare impacts
- Indigenous Studies and Ecology
- Respiratory Support and Mechanisms
- COVID-19 and Mental Health
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- Intensive Care Unit Cognitive Disorders
- Musculoskeletal Disorders and Rehabilitation
- Healthcare cost, quality, practices
- Global Cancer Incidence and Screening
- Frailty in Older Adults
- Breast Cancer Treatment Studies
- Technology Use by Older Adults
- SARS-CoV-2 detection and testing
- Optimism, Hope, and Well-being
James Cook University Hospital
2018-2024
NIHR Newcastle Biomedical Research Centre
2023
Newcastle University
2019-2023
South Tees Hospitals NHS Foundation Trust
2023
University of Sheffield
2022
University of Ulster
2022
University Hospital of North Durham
2021-2022
Royal Victoria Hospital
2022
Darlington Memorial Hospital
2021
Institute of Cancer Research
2016
Abstract Background Trauma places a significant burden on healthcare services, and its management impacts greatly the injured patient. The demographic of major trauma is changing as population ages, increasingly unveiling gaps in processes managing older patients. Key to improving patient care ability characterise current distribution. Objectives There no contemporary evidence available how age distribution at national level. Through an analysis Audit Research Network (TARN) database, we...
Background The AGILE CST-8 ( NCT04746183 ) Phase I de-escalation trial evaluated the safety and tolerability of combination molnupiravir nirmatrelvir/ritonavir for mild-moderate COVID-19. Methods Adult out-patients with SARS-CoV-2 infection within five days symptoms were randomly assigned 2:1 to receive (starting at 800mg twice daily (BD) reducing 600mg 400mg if necessary) in nirmatrelvir (300mg)/ritonavir (100mg) BD 5 versus Standard care. Using a dose de-escalation, open-label, Bayesian...
Objective Digital devices have demonstrated benefits to patients with chronic and neurodegenerative diseases. But when use medical in their homes, the technologies fit into lives. We investigated technology acceptance of seven digital for home use. Methods conducted 60 semi-structured interviews participants a larger device study on views acceptability devices. Transcriptions were analysed using qualitative content analysis. Results Based unified theory technology, we evaluated effort,...
Malnutrition is common in older people, known to interact with frailty, and a risk factor for wound complications poor functional outcomes postoperatively. Sustaining hip fracture significant life event, often resulting decline mobility ability. A nutritional state may further impede recovery rehabilitation, so strategies improve perioperative nutrition are of considerable importance. We provide review supplement practices this vulnerable growing population.Systematic preoperative oral...
Patients with A1 and A2 trochanteric hip fractures represent a substantial proportion of trauma caseload, national guidelines recommend that sliding screws (SHS) should be used for these injuries. Despite this, intramedullary nails (IMNs) are routinely implanted in many hospitals, at extra cost unproven patient outcome benefit. We have data from the National Hip Fracture Database (NHFD) to examine use SHS IMN level, define implications management decisions run counter guidelines.We NHFD...
Patella fractures are uncommon injuries but in frail patients they may confer significant morbidity. Tension band metallic wiring (TBW) is frequently employed to manage these yet complication rates high. Up one-third of require reoperation. In the host especially, patella can result functional impairment impacting on independence. Using PRISMA guidelines, this systematic review interrogates literature host. The evidence was found be minimal and low quality, comprising only eight cohort...
Patients with hip fractures pose a significant burden on health services. Malnutrition, frailty, and cognitive impairment are common, key to addressing the needs of this vulnerable patient group is nutrition optimization, including reduction in arbitrary nil by mouth (NBM) perioperative regimens. In order understand current practices, we characterize preoperative regional fracture population.Prospective data were submitted National Hip Fracture Database 6 hospitals north east England over...
Abstract Background: Neoadjuvant endocrine therapy allows biological studies of de novo response and resistance but not acquired based on clinical endpoints as surgery is usually carried out after around 4 months. Response associated with a significant fall in Ki67 (proliferation) 2 weeks treatment. However, at 12/16 weeks, c.15% tumours show recovery Ki67. We hypothesized that this reflected rapidly treatment have assessed its relevance association tumour biomarkers.Methods: Ki67, ER, PgR...
Abstract AimTo identify molecular sub-classes of endocrine-resistant breast tumours.MethodsWhole genome expression profiles 55 tumours were obtained using Illumina HT-12 BeadChip arrays. Endocrine resistance was defined as either (i) tumour increased in size during hormonal treatment or (ii) appearance local recurrence (iii) contra-lateral lesion (metastases new cancers) treatment. Most the treated patients post-menopausal. Hormonal included aromatase inhibitors (letrozole, anastrazole,...
Patients with hip fractures can become cold during the perioperative period despite measures applied to maintain warmth. Poor temperature control is linked increasing complications and poorer functional outcomes. There generic evidence for benefits of maintaining normothermia, however this sparse where specifically concerning fracture. We provide first comprehensive review in population.Large studies have revealed dramatic impact on wound infection, transfusion rates, increased morbidity...
Abstract RationalemiRNAs are a relatively recently discovered class of molecules with major implications in cellular biology, including tumorigenesis; yet little is known about their possible involvement the development endocrine resistance breast cancer. The aim this study was to identify sub-groups endocrine-resistant tumours distinctive miRNA profiles.Methods and ResultsFrozen biopsies were obtained from series 51 cancers, which either progressing primary tumours, local recurrences or...
Abstract Background:Aromatase inhibitors (AIs) reduce circulating oestrogen which may have a detrimental effect on lipid metabolism and subsequently ↑ cardiovascular risk. This study compares the effects of adjuvant A, L E metabolism.Patients Methods:This was an open, randomised pharmacodynamic study. Plasma lipids were measured in 120 postmenopausal women with invasive ER +ve breast cancer. As part their hormone therapy, patients randomized to receive either:• 4 months A or• EFasting blood...