A5064630672- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Asthma and respiratory diseases
- Neuroscience and Neuropharmacology Research
- Tracheal and airway disorders
- Ion channel regulation and function
- Congenital heart defects research
- Infant Development and Preterm Care
- Iron Metabolism and Disorders
- Neuroscience of respiration and sleep
- Inhalation and Respiratory Drug Delivery
- Hemoglobinopathies and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Cancer, Hypoxia, and Metabolism
- Family and Patient Care in Intensive Care Units
- Pharmacological Receptor Mechanisms and Effects
- Healthcare Systems and Technology
- Electronic Health Records Systems
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmaceutical studies and practices
- Cerebral Palsy and Movement Disorders
- Vitamin D Research Studies
- Occupational exposure and asthma
Yale University
2008-2020
Respiratory Clinical Trials
2008-2016
Riley Hospital for Children
2016
Indiana University – Purdue University Indianapolis
2016
Indiana University School of Medicine
2016
Boston Children's Hospital
2014
Case Western Reserve University
2009
Pediatrics and Genetics
2008
Yale New Haven Hospital
2006
OBJECTIVES. The objectives of this study were (1) to determine the prevalence and risk factors elevated pulmonary artery pressures in children with homozygous SS or Sβ° thalassemia using Doppler echocardiography (2) a correlation between abnormal transcranial examinations pressures. METHODS. Screening echocardiograms prospectively performed during an annual comprehensive clinic visit on who older than 6 years had thalassemia. Detailed history, examination, laboratory tests done, obtained 2...
<b><i>Background:</i></b> Pulmonary hypertension (PH) in infants with bronchopulmonary dysplasia (BPD) is associated increased morbidity and mortality. Elevated levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) decreased amino acid precursors nitric oxide (NO) have been PH, but not studied PH secondary to BPD. <b><i>Objective:</i></b> The aim this study was identify a biochemical marker for...
OBJECTIVE. The purpose of this work was to determine whether, in children with metabolic syndrome and sleep-disordered breathing, markers separate them from without breathing whether treatment continuous positive airway pressure is associated an improvement derangement. PATIENTS AND METHODS. Subjects aged 7 19 years old a validated sleep questionnaire were recruited. underwent overnight polysomnography, during which sympathetic nervous system activity assessed via 8-hourly measurements...
Abstract Past work has shown that δ‐opioid receptor (DOR) activation by [D‐Ala 2 ,D‐Leu 5 ]‐enkephalin (DADLE) attenuated the disruption of K + homeostasis induced hypoxia or oxygen‐glucose deprivation (OGD) in cortex, while naltrindole, a DOR antagonist blocked this effect, suggesting activity stabilizes cortex during hypoxic/ischemic stress. However, several important issues remain unclear regarding new observation, especially difference between and other opioid receptors stabilization...
Summary Elevated pulmonary artery pressures (PAP) occur in approximately 30% of children with sickle cell disease. In adults, hypertension is significantly associated mortality. There are no data on the long term significance children. Nineteen SS/Sß 0 thalassaemia had elevated PAP, defined as tricuspid regurgitant jet velocity (TRV) ≥2·5 m/s screening echocardiograms. They were prospectively followed for 23 months (range 19–31 months). Patients initial TRV ≥ 3 or 2·5 repeat echocardiogram...
Abstract Using a mouse model of neonatal respiratory distress syndrome (RDS), we demonstrate central role for macrophage migration inhibitory factor (MIF) in lung maturation at the developmental stage when human neonates are most susceptible to RDS. We prematurely delivered pups embryonic day 18, during early saccular pulmonary development. Only 8% genetically deficient MIF survived 8 h vs 75% wild-type controls (p &lt; 0.001). This phenotype was corrected all genotypes were bred from...
Section:ChooseTop of pageAbstract <<ContentsOverviewIntroductionUse These GuidelinesMethodsResultsLimitations and Future Di...ReferencesCITING ARTICLES
Central neurons are extremely vulnerable to hypoxic/ischemic insult, which is a major cause of neurologic morbidity and mortality as consequence neuronal dysfunction death. Our recent work has shown that δ-opioid receptor (DOR) neuroprotective against hypoxic excitotoxic stress, although the underlying mechanisms remain unclear. Because hypoxia/ischemia disrupts ionic homeostasis with an increase in extracellular K + , plays role death, we asked whether DOR activation preserves during...
We have recently found that in the mouse cortex, activation of delta-opioid receptor (DOR) attenuates disruption K(+) homeostasis induced by hypoxia or oxygen-glucose deprivation. This novel observation suggests DOR may protect neurons from hypoxic/ischemic insults via regulation because plays a critical role neuronal injury under stress. The present study was performed to explore ionic mechanism underlying DOR-induced neuroprotection. Because anoxia causes Na(+) influx and thus stimulates...
Objective To evaluate the accuracy of a computerized clinical decision-support system (CDSS) designed to support assessment and management pediatric asthma in subspecialty clinic.
Objective. Asthma is a leading cause of emergency department visits and hospitalizations for children in the United States. As part larger study, purpose this analysis was to determine which variables were most effective at predicting subsequent pediatric asthma-related hospitalizations. Methods. A retrospective, descriptive study conducted. Subjects consisted convenience sample 298 admitted New England Children's Hospital 2006 with primary diagnosis asthma. Data from two hospital databases...
Objective. Asthma is a leading cause of emergency department visits and hospitalizations for children in the United States. As part larger study, purpose this analysis was to determine which variables were most effective at predicting subsequent pediatric asthma-related hospitalizations. Methods. A retrospective, descriptive study conducted. Subjects consisted convenience sample 298 admitted New England Children's Hospital 2006 with primary diagnosis asthma. Data from two hospital databases...
BACKGROUND: Although e-mail may be an efficient clinician-patient communication tool, standard is not adequately secure to meet Health Insurance Portability and Accountability Act (HIPAA) guidelines. For this reason, firewall-secured electronic messaging systems have been developed for use in health care. Impact usability of these broadly assessed. OBJECTIVE: To evaluate the impact a system implemented pediatric subspecialty clinic. METHODS: This study was performed outpatient, academic...
We report undescribed pulmonary findings in a child with mucolipidosis II (ML-II). Children ML-II bear significant morbidity that may include extensive fibrosis, persistent hemosiderosis as well airway excrescences they reach preschool age.
To safely discharge a child with tracheostomy tube to home, we require two legal guardians/parents complete special training program. However, there are times when parents/guardians unavailable or unwilling be trained. Therefore, the purpose of this study was evaluate role second caregiver in home setting.A retrospective, descriptive, qualitative, pilot convenience sample parents 16 children who were discharged from hospital between September 2004 and December 2008 conducted. Data obtained...
We report a 19-year-old man with pulmonary squamous cell carcinoma (SCC) who had history of vertebral, anal, cardiac, tracheal, esophageal, renal, and radial limb defects (VACTERL) association tracheoesophageal fistula (TEF) + esophageal atresia (EA) repair as an infant. Children that undergo TEF EA may have increased risk for developing cancer they reach adulthood.
Aim: To identify variables that affect the risk of tracheostomy in a population extremely low birth weight (ELBW) infants.Methods: A retrospective matched case–control study was conducted. ELBW infants with were compared controls without tracheostomy. Data collection included demographics, detailed information about each intubation and extubation attempt, use steroids presence comorbidities. Statistical analyses include conditional logistic regression Poisson for clustered...