A5071653094- Vitamin D Research Studies
- Diet and metabolism studies
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Regulation of Appetite and Obesity
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Digestive system and related health
- Hormonal Regulation and Hypertension
- Thyroid Disorders and Treatments
- Stress Responses and Cortisol
- Adrenal Hormones and Disorders
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Iron Metabolism and Disorders
- Food composition and properties
- Vitamin C and Antioxidants Research
- Retinoids in leukemia and cellular processes
- Biochemical Analysis and Sensing Techniques
- Microscopic Colitis
Iowa State University
2014-2024
Tufts University
2017
University of Notre Dame
2006-2007
Altered serum concentrations of the major circulating form vitamin D [25-hydroxycholecalciferol (25D 3 )] and its active hormone derivative [1,25-dihydroxycholecalciferol (1,25D have been linked to non-insulin-dependent diabetes mellitus (NIDDM). However, a mechanistic basis for this occurrence has not fully elucidated. Normally, renal reabsorption D-binding protein-bound 25D absolutely requires receptor-mediated endocytosis via receptor complex containing megalin, cubilin, disabled-2...
Megalin and disabled-2 (Dab2) are essential for uptake of the 25-hydroxycholecalciferol (25D3)-vitamin D binding protein (DBP) complex in tissues. In kidney, this mechanism regulates serum 25D3 levels production 1,25-dihydroxycholecalciferol (1,25D3) by CYP27B1 systemic use. Previously, we showed that mammary epithelial cells expressing express megalin Dab2 internalize DBP endocytosis, indicating was accessible conversion to 1,25D3 extra-renal Moreover, induction (protein mRNA abundance)...
We previously demonstrated that feeding of dietary resistant starch (RS) prior to the induction diabetes delayed progression diabetic nephropathy and maintained vitamin D balance in streptozotocin (STZ)-induced type 1 (T1D) rats. Here, we examined impact RS on kidney function homeostasis following STZ injection. Male Sprague-Dawley rats were administered fed a standard diet containing cornstarch or 20, 10, 5% for 4 weeks. T1D 10 20% RS, but not gained more weight than cornstarch-fed Yet,...
Type 2 diabetes (T2D) is characterized by vitamin D deficiency owing to increased urinary loss of 25-hydroxycholecalciferol (25D). Whole eggs are a rich source D, particularly 25D, the circulating form that reflects status. Zucker diabetic (type 2) fatty (ZDF) rats and their lean counterparts were fed casein- or whole egg-based diets for 8 weeks. egg consumption attenuated both hyperglycemia hypertriglyceridemia, as well reduced weight gain in ZDF compared casein-fed rats. Circulating 25D...
The literature regarding the relation between egg consumption and type 2 diabetes (T2D) is inconsistent there limited evidence pertaining to impact of on measures insulin sensitivity.
Nephropathy is a well-characterized complication of type 1 diabetes (T1D), resulting in proteinuria and urinary loss micronutrients. We previously found that whole egg-based diet maintained vitamin D balance 2 diabetic rats despite excessive losses due to nephropathy. The goal this study was investigate the impact egg consumption T1D rats. Sprague-Dawley were randomly assigned or nondiabetic control groups fed casein for 32 days. On day 26, two-thirds received streptozotocin injection induce...
25-hydroxyvitamin D (25OH D) 1α-hydroxylase (CYP27B1) knockout (KO) mice are growth retarded, hypocalcemic, and have osteomalacia. This can be prevented by 1,25 dihydroxyvitamin (1,25 injections or feeding a 2% calcium (Ca), 20% lactose rescue diet. We tested whether high dietary vitamin D3 (VD) could exert biological effects in the absence of CYP27B1 vivo. Male weanling KO wild-type (WT) were randomized to diet AIN93G diets (0.5% Ca, 0.4% phosphorus) with 1,000 (1K, rodent requirement),...