A5047201285- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Sexual function and dysfunction studies
- Gynecological conditions and treatments
- Reproductive System and Pregnancy
- Hormonal and reproductive studies
- Ovarian function and disorders
- COVID-19 and healthcare impacts
- Sexual Differentiation and Disorders
- Genital Health and Disease
- Menopause: Health Impacts and Treatments
- Breast Cancer Treatment Studies
- Ectopic Pregnancy Diagnosis and Management
- Urinary and Genital Oncology Studies
- Cancer and Skin Lesions
- Prenatal Screening and Diagnostics
- Estrogen and related hormone effects
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Pelvic floor disorders treatments
- Pregnancy-related medical research
University of Florence
2015-2024
University of Birmingham
2020-2022
Institut de Virologie
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
AstraZeneca (Brazil)
2020
Stryker (United Kingdom)
2020
Pfizer (United Kingdom)
2020
We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and all IL-17-producing cells are contained the CD161(+) fraction of CD4(+) present circulation or inflamed tissues, although they not CD1-restricted natural killer cells. More importantly, we show originate from naive umbilical cord blood, as well postnatal thymus, response to combined activity IL-1 beta IL-23. These findings implicate novel surface marker for Th17 exclusive...
To report the long-term results of external-beam accelerated partial-breast irradiation (APBI) intensity-modulated radiation therapy (IMRT) Florence phase III trial comparing whole-breast (WBI) to APBI in early-stage breast cancer.The primary end point was determine 5-year difference ipsilateral tumor recurrence (IBTR) between 30 Gy 5 once-daily fractions (APBI arm) and 50 25 with a bed boost (WBI after breast-conserving surgery.Five hundred twenty patients, more than 90% whom had...
Abstract We have previously shown that human Th17 lymphocytes are characterized by the selective expression of IL‐23 receptor (IL‐23R), CCR6, CD161, and transcription factor retinoic acid‐related orphan C (RORC), originate from a CD161 + CD4 naïve T‐cell precursor in response to combined activity IL‐1β IL‐23. show here not only TCRαβ , but also CD8 − TCRγδ circulating produce IL‐17 express distinctive marker on their surface. In addition, we demonstrate identifies umbilical cord blood T...
Does the methylation status of promoter region HOXA10 gene differ in eutopic and ectopic endometrium?The endometrium women with endometriosis is significantly more methylated when compared controls.Expression gene, which important for successful implantation, reduced affected by endometriosis.A pilot study was carried out including 18 admitted surgery endometriosis-related pain (cases) 12 because non-endometriotic disease (control). Sample collection analysis were performed between November...
What is the prevalence of adenomyosis at ultrasonography among adolescents and young women reporting dysmenorrhoea and/or heavy menstrual bleeding (HMB)?
Chronic inflammation is involved in the genitourinary syndrome of menopause (GSM) and beneficial effects androgens vagina have been described. We investigated potential involvement human smooth muscle cells (hvSMCs) inflammatory response immunomodulatory effect androgen receptor (AR) agonist dihydrotestosterone (DHT). HvSMCs isolated from menopausal women were evaluated for sex steroids receptors toll-like mRNA expression, left untreated or treated vitro with lipopolysaccharide (LPS) IFNγ,...
Abstract Background BRCA mutation carriers opting for prophylactic risk-reducing salpingo-oophorectomy (RRSO) face potential impacts on sexual functioning and body image. Aim The aim of the study was to assess extent dysfunction (SD) image impairment in patients, both with without cancer, before after undergoing RRSO. Methods present cross-sectional involved a group BRCA-positive patients (n = 220) from Gynecological Hereditary Cancer Risk Clinic, categorized into two different subgroups:...