A5063871266- Autism Spectrum Disorder Research
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Tryptophan and brain disorders
- Mesenchymal stem cell research
- Treatment of Major Depression
- Metabolism, Diabetes, and Cancer
- Alkaloids: synthesis and pharmacology
- Cellular transport and secretion
- Ion channel regulation and function
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Child Development and Digital Technology
- Neurogenesis and neuroplasticity mechanisms
- PI3K/AKT/mTOR signaling in cancer
Guangzhou Sport University
2020-2024
Southern Medical University
2016-2019
Rationale: Repeated methamphetamine (METH) exposure induces long-term cognitive deficits and pathological drug-associated memory that can be disrupted by manipulating reconsolidation extinction. The nucleus accumbens (NAc) is the key region of brain reward system predominantly consists two subtypes medium spiny neurons (MSNs) based on expression D1 or D2 dopamine receptors (D1-MSNs D2-MSNs). Spine structural plasticity in NAc critical for acquisition, extinction memory. However, molecular...
Synaptic plasticity plays a critical role in cocaine addiction. The dopamine D1 and D3 receptors differentially regulate the cocaine-induced gene expression, structural remodeling behavioral response. However, how these two coordinately mediate ultra-structural changes of synapses after exposure whether are behaviorally relevant still not clear. Here, using quantitative electron microscopy, we show that have distinct roles regulating nucleus accumbens caudoputamen. Pre-treatment...
Pharmacognosy Magazine,2018,14,53,81-86.DOI:10.4103/pm.pm_90_17Published:February 2018Type:Original ArticleAuthors:Youli Guo, Chaohua Luo, Genghong Tu, Chan Li, Yi Liu, Wei Ken Kin Lam Yung, and Zhixian Mo Author(s) affiliations:Youli Guo1, Luo2, Tu3, Li2, Liu2, Yung4, Mo2 1 School of Traditional Chinese Medicine, Southern Medical University; Department Pharmacy, Guangdong Provincial Corps Hospital People's Armed Police Forces, Guangzhou, China 2 University, 3 Pathophysiology, Province Key...
Background The key neural pathological characteristics of autism spectrum disorder (ASD) include abnormal synaptic plasticity the medial prefrontal cortex (mPFC). Exercise therapy is widely used to rehabilitate children with ASD, but its neurobiological mechanism unclear. Methods To clarify whether structural and molecular synapses in mPFC are related improvement ASD behavioral deficits after continuous exercise rehabilitation training, we applied phosphoproteomic, behavioral, morphological,...
The mTOR pathway serves an important role in the development of insulin resistance induced by obesity. Exercise improves obesity‑associated and hepatic energy metabolism; however, precise mechanism this process remains unknown. Therefore, present study investigated rapamycin, inhibitor mTOR, on exercise‑induced expression metabolism genes rats fed a high‑fat diet (HFD). A total 30 male were divided into following groups: Normal group (n=6) chow diets HFD (n=24) for 6 weeks. performed...
Ketamine is a drug of abuse worldwide and current treatments for ketamine are inadequate. It an urgent need to develop novel anti-addictive strategy. Since gut microbiota plays crucial role in abuse, the present study investigates impact mechanisms addictive behaviors induced by addiction.