The aim of the present retrospective study was to compare microRNA (miR)‑146a expression levels in primary tumors and omental metastases 48 patients, who had undergone surgery for advanced ovarian serous cancer. Possible correlations between miR‑146a level clinicopathological features were investigated, including chemosensitivity survival. evaluated formalin‑fixed, paraffin‑embedded samples. demonstrated be increased comparison with normal ovary tissues (P=0.02) (P=0.01). A negative...

Acta Obstet Gynecol Scand 2003; 82: 69–73. © 2003 Background. To compare the efficiency of low‐calorie diet and applied together with laser acupuncture in therapy visceral obesity postmenopausal women. Methods. The study population consisted 74 females who were divided into two groups according to an employed 6‐month slimming procedure. In first group ( n = 36) a was applied, while women second 38) on same kind diet, having additionally one cycle procedure at time. At baseline end study,...

The prognostic value of the MDM2 gene amplification/expression in many types cancer remains unclear. Polymorphisms promoter region have been shown to alter protein expression and thus, may play a role carcinogenesis. aim present study was evaluate association between risk endometrial SNP309 polymorphisms gene. genotype analysis 152 patients 100 controls cancer-free subjects, Polish population, performed using PCR-based restriction fragment length polymorphism (PCR-RFLP). In presented study,...

Ectopic pregnancy (EP) is usually located in the Fallopian tube and it has a significant adverse effect on womens fertility Three types of EP treatment include: expectant, medical, surgical radical (salpingectomy) or conservative (salpingotomy) management.The aim study was to compare women's after tubal ectopic pregnancyOut 58 patients operated because 22 underwent laparoscopic salpingotomy (group 1) 36 salpingectomy 2). EP-related data were obtained from medical documentation (the symptoms,...

Objectives: 2D/3D transvaginal ultrasonography in evaluation of endometrium postmenopausal women with abnormal uterine bleedings (AUB). Material and methods: (TVU) was performed 118 menopausal AUB. Endometrial volume thickness, endometrial vascularity were evaluated. Complete histologic the obtained through dilatation & curettage (D&C) and/or hysteroscopy. Accordingly, patients divided into 3 groups: controls (no pathology, n = 49), GI (benign 37), GII (endometrial carcinoma, 32)....

Background.Clinical cases have been reported with women who got pregnant confirmed low serum anti-Müllerian hormone (AMH) concentrations, thus demonstrating that AMH concentration cut-points could be fairly specific for poor ovarian response (POR) to gonadotrophin stimulation, but not pregnancy.That observation prompted the question whether accurately corresponded whole amount of secreted by granulosa cells.Objectives.To measure levels in peritoneal fluid and their correlations...

Thirty-nine women of reproductive age suffering from chronic pelvic inflammatory disease (PID) for at least two years, previously treated pharmacologically with no effect, were enrolled in a four-week therapeutic protocol consisting 12 acupuncture treatments performed the frequency three per week. In each female patient baseline and after study, pain score following parameters blood serum evaluated: concentration immunoglobulin M (IgM), albumins, α 1 -globulins, 2 -globulins γ-globulins,...

1. The 2012 Hormone Therapy Position Statement of the North American Menopause Society. 2012; 19(3): 257–271. Google Scholar

The aim of this study was to detect TP53 Arg72Pro polymorphism in postmenopausal patients with endometrial cancer (EC), evaluate the risk EC connected it, as well check for possible relationships staging, grading and some factors neoplasm.Endometrial samples from 152 women 50 cancer-free ones were taken genetic evaluation codon 72 variability using PCR-RFLP technique.The group characterized by higher incidence Arg/Arg genotype (OR=3.01) lower Pro/Arg Pro allele (OR=0.33 0.48). There no...

Background. The widespread availability of ultrasonography means that transvaginal has become a routine procedure during gynecological examinations, even in asymptomatic patients. Nowadays the imaging technology offered by and tumor biomarkers give us an opportunity to implement ultrasound-guided aspiration as less radical treatment simple ovarian cysts (SOC).Objectives. aim study was retrospective evaluation diagnostic therapeutic efficacy SOC postmenopausal premenopausal patients.Material...

Significant relationships with endometrial cancer were demonstrated, both for CCL2, CCL5, and CXCL8 chemokines the chemokine receptor CXCR2. The reported case-control study of genetic associations was designed to establish role selected single nucleotide polymorphisms (SNPs) CXCL8, CXCR2 genes in onset progression cancer. This conducted on 282 women, including 132 (46.8%) patients 150 (53.2%) non-cancerous controls. genotypes CCL2 rs4586, CCL5 rs2107538 rs2280789, rs2227532 −738 T>A,...

The aim of this study was to determine the joint effect single nucleotide polymorphisms (SNPs) MDM2, TP53, and CDKN2A (P14ARF) genes on onset course endometrial cancer (EC) in postmenopausal women.The group consisted 144 EC women 50 non-cancer controls. MDM2 rs22279744, TP53 rs1042522, P14ARF rs3088440, rs3731217, rs3731245 SNPs were analysed.The double-SNP combinations T-C, T-T, or T-G SNP 309 decreased risk. triple-SNP T-C-T, T-C-G, T-T-G two multiple-SNP combination T-C-T-G three...