A5056491840- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
- Diagnosis and treatment of tuberculosis
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Infectious Diseases and Tuberculosis
- Parvovirus B19 Infection Studies
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Herpesvirus Infections and Treatments
- Zoonotic diseases and public health
- COVID-19 epidemiological studies
- Chemistry and Stereochemistry Studies
- Neonatal and Maternal Infections
- Respiratory viral infections research
- HIV/AIDS Impact and Responses
- Autopsy Techniques and Outcomes
- HIV/AIDS Research and Interventions
- Sepsis Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Malaria Research and Control
University of Lincoln
2018-2025
University College London
2014-2024
University Teaching Hospital
2015-2024
Detroit Medical Center
2024
Lincoln University - Pennsylvania
2024
Sinai Grace Hospital
2024
Wayne State University
2024
The Royal Free Hospital
2005-2023
University of Zambia
2011-2022
MRC University of Glasgow Centre for Virus Research
2022
Patients with highly drug-resistant forms of tuberculosis have limited treatment options and historically had poor outcomes.
The bedaquiline-pretomanid-linezolid regimen has been reported to have 90% efficacy against highly drug-resistant tuberculosis, but the incidence of adverse events with 1200 mg linezolid daily high. appropriate dose and duration treatment this agent minimize toxic effects while maintaining tuberculosis are unclear.We enrolled participants extensively (XDR) (i.e., resistant rifampin, a fluoroquinolone, an aminoglycoside), pre-XDR rifampin either fluoroquinolone or rifampin-resistant that was...
SummaryBackgroundThe broad use of bedaquiline and pretomanid as the mainstay new regimens to combat tuberculosis is a risk due increasing resistance. We aimed assess safety, bactericidal activity, pharmacokinetics BTZ-043, first-in-class DprE1 inhibitor with strong activity in murine models.MethodsThis open-label, dose-expansion, randomised, controlled, phase 1b/2a trial was conducted two specialised sites Cape Town, South Africa. Adults aged 18–64 years newly diagnosed pulmonary sensitive...
BackgroundAn accurate biomarker is urgently needed to monitor the response treatment in patients with pulmonary tuberculosis. The Xpert MTB/RIF assay a commercially available real-time PCR that can be used detect Mycobacterium-tuberculosis-specific DNA sequences sputum samples. We therefore evaluated this serial samples obtained over 26 weeks from undergoing for tuberculosis.MethodsWe analysed 221 smear-positive tuberculosis enrolled at two sites (Cape Town, South Africa, and Mbeya,...
A molecular assay to quantify Mycobacterium tuberculosis is described. In vitro, 98% (n = 96) of sputum samples with a known number bacilli (10(7) 10(2) bacilli) could be enumerated within 0.5 log(10). comparison culture, the bacterial load (MBL) unaffected by other microorganisms present in sample, results are obtained more quickly (within 24 h) and seldom inhibited (0.7% samples), MBL critically shows same biphasic decline as observed longitudinally during treatment. As biomarker treatment...
Despite concerted efforts over the past 2 decades at developing new diagnostics, drugs, and vaccines with expanding pipelines, tuberculosis remains a global emergency. Several novel diagnostic technologies show promise of better point-of-care rapid tests for including nucleic acid-based amplification tests, imaging, breath analysis volatile organic compounds. Advances in repurposed drugs use multidrug-resistant (MDR) or extensively drug-resistant (XDR) have focused on development several...
The appearance of novel pathogens humans with epidemic potential and high mortality rates have threatened global health security for centuries. Over the past few decades new zoonotic infectious diseases caused by arising from animal reservoirs included West Nile virus, Yellow fever Ebola Nipah Lassa Fever Hanta Dengue Rift Valley Crimean-Congo haemorrhagic severe acute respiratory syndrome coronavirus, highly pathogenic avian influenza viruses, Middle East Respiratory Syndrome Coronavirus,...
In sub-Saharan Africa, there is scanty data on the causes of neonatal sepsis and antimicrobial resistance among common invasive pathogens that might guide policy practice.A cross-sectional observational prevalence etiology study neonates with suspected admitted to intensive care unit, University Teaching Hospital, Lusaka, Zambia, between October 2013 May 2014. Data from blood cultures phenotypic antibiotic susceptibility testing were compared multivariate analysis risk factors for sepsis.Of...
Abstract Objectives To develop a robust phenotypic antimicrobial susceptibility testing (AST) method with correctly set breakpoint for pretomanid (Pa), the most recently approved anti-tuberculosis drug. Methods The Becton Dickinson Mycobacterial Growth Indicator Tube™ (MGIT) system was used at six laboratories to determine MICs of phylogenetically diverse collection 356 Mycobacterium tuberculosis complex (MTBC) strains establish epidemiological cut-off value pretomanid. were correlated WGS...