A5087501523- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Proteoglycans and glycosaminoglycans research
- Biomedical Ethics and Regulation
- Animal Genetics and Reproduction
- Pancreatic function and diabetes
- Testicular diseases and treatments
- Reproductive Health and Technologies
- Diabetes Management and Research
- Infrared Thermography in Medicine
- Diabetes and associated disorders
Wellcome Sanger Institute
2023
University of Lincoln
2023
University of Leeds
2016-2022
What effects did treatment using hyaluronic acid (HA) binding/selection prior to ICSI have on clinical outcomes in the Hyaluronic Acid Binding sperm Selection (HABSelect) trial?Older women randomized trial's experimental arm (selection of bound immobilized (solid-state) HA) had same live birth rates as younger women, most likely a result better avoidance with damaged DNA.Recent controlled trials (RCTs) investigating efficacy HA-based selection ICSI, including HABSelect, consistently reported...
The male gamete is not completely mature after ejaculation and requires further events in the female genital tract to acquire fertilizing ability, including processes of capacitation acrosome reaction. In order shed light on protein changes experienced by sperm cell preparation for fertilization, a comprehensive quantitative proteomic profiling based isotopic peptide labeling liquid chromatography followed tandem mass spectrometry was performed spermatozoa from three donors proven fertility...
Are there novel hyaladherins in human sperm? Zona pellucida-binding protein 2 (ZPBP2), containing a Link-like hyaluronic acid (HA)-binding domain, and several other proteins BX7B motifs, such as ADAM32 Midkine, may be with HA-binding properties. (hyaladherins), which can bind HA surrounding the cumulus-oophorus complex, are distinct from hyases PH 20 (SPAM1) expressed by mature spermatozoa. Although HABP1 CD44 reasonably well characterized former has been implicated sperm-oocyte...
Morphological studies of pancreas samples obtained from young people with recent-onset type 1 diabetes have revealed distinct patterns immune cell infiltration the pancreatic islets suggestive two age-associated endotypes that differ by inflammatory responses and rates disease progression. The objective this study was to investigate whether these proposed are associated pathological differences in activation cytokine secretion applying multiplexed gene expression analysis tissue cases.RNA...
(Abstracted from Hum Reprod 2022;37:1106–1125) With intracytoplasmic sperm injection (ICSI), many natural barriers that would normally prevent the entry of abnormal are lost, increasing importance DNA integrity for successful in vitro fertilization. There is currently no consensus on optimal assay measuring quality (DNAq), defined as any structural aspect chromatin can compromise function if disrupted.
Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)