Coronavirus disease-2019 (COVID-19) is a global health emergency and the matter of serious concern, which has been declared pandemic by WHO. Till date, no potential medicine/ drug available to cure infected persons from SARS-CoV-2. This deadly virus named as novel 2019-nCoV coronavirus caused disease, that is, COVID-19. The first case SARS-CoV-2 infection in human was confirmed Wuhan city China. COVID-19 an infectious disease spread man well surface . In present work, silico approach...

A theoretical model was developed to allosterically inhibit the biological activity of dengue virus (DENV) by targeting non-structural protein ns2B-nsP3 protease based on in silico studies. The imidazole, oxazole, triazole, thiadiazole, and thiazolidine scaffolds were imported from ZINC database, reported various research group with different activity. They found biologically active as they contain heterocyclic fragments. Generic evolutionary molecular docking performed screen highly potent...

Abstract Contemplating the exemplary benefits of pectin on human health, we precisely characterized and evaluated antibacterial anticancer activities from purified Mulberry Fruit Pectins (MFP). Here, tested BR-2 S-13 varieties mulberry fruit pectins against six bacterial strains two cancer cell lines (HT-29 Hep G-2), using MIC an in vitro cell-based assay respectively. The performs superior to by inhibiting strong growth (MIC = 500–1000 μg/mL) cytotoxic at lowest concentration (10 µg/ml) G-2...

COVID-19 has affected more or less every nation across the world and economy very badly. Infection of this virus in human took life millions. We have already faced first second waves recently, nations humanity is afraid new strain, that is, OMICRON. Considered to highly infectious than previous strains. Therefore, researchers are working find a promising molecule with no permissible toxicity. In present work, authors chosen 10 molecules including used curing infection from nCoV. All were...

Mn(II) and Cu(II) complexes having the formula [M(L)2 ]X2 of ligand, i. e., 2-acetyl-5-methylfuranthiosemicarbazone were synthesized. Various analytical spectroscopic techniques described structure synthesized complexes. Molar conductance confirmed electrolytic nature The theoretical study explained structural property reactivity. chemical reactivity, interaction stability ligand metal studied with help global reactivity descriptors. MEP analysis was used to investigate charge transfer in...

Chikungunya fever is a major public health issue in India affecting millions of people and occurs due to Chikungunya. virus (CHIKV) single stranded RNA from the family Togaviridae genus alpha virus. It contain three structural proteins: glycosylated E1 E2, embedded viral envelope, non-glycosylated nucleocapsid protein. Till date, researchers are working on inhibition CHIKV but till now no cheap effective medicine available market. Therefore, authors this work thought isoquinoline based...

COVID-19 has threatened the existence of humanity andthis infection occurs due to SARS-CoV-2 or novel coronavirus, was first reported in Wuhan, China. Therefore, there is a need find promising drug cure people suffering from infection. The second wave this viral shaking world half 2021. Drugs Controllers India allowed emergency use 2-deoxy-D-glucose (2DG) 2021 for patients potentiality intervene D-glucose metabolism exists and energy deprivation an effective parameter inhibit cancer cell...

Abstract Mn(II) and Co(II) complexes of methyl‐(Z)−N′‐carbamothioylcarbamohydrazonate Schiff base ligand were synthesized. The metal salts taken in 2 : 1 stoichiometric ratio. All the synthesized characterized using elemental analysis, molar conductance, magnetic moment various spectroscopic techniques (FT‐IR, UV/VIS, EPR) techniques. Elemental results verified bidentate donor nature octahedral geometry all complexes. non‐electrolytic suggested by conductivity data analysis. In vitro...

Abstract Dengue fever is a severe disease in the present time. Based on literature, there no effective approved medicine available market for treatment of dengue fever. This spreading rapidly and an urgency to find potential cost‐effective antiviral compounds development cure patients from Different computational experimental approaches have been tried inhibitors nsP2B‐nsP3 protease virus. In work, four component one‐pot reaction was designed get pyrrolothiazolones & its mechanism...

Noscapine (narcotine) is an opium alkaloid, isolated from Papaver somniferum L. being used in clinical trials for curing cancer. Till date researchers mainly discussed the erythro form of noscapine but present work authors have as well threo noscapine. In work, library 11 derivatives each threo- and erythro- isomer was created virtually screened their chemotherapeutic efficacy on Tyrosine Kinase Domain Epidermal Growth Factor Receptor (PDB-1M14). The interaction between noscapines studied by...

Computer docking provides the necessary data for biochemists, chemists, and pharmacologists to design study ligands various proteins identifying that bind effectively in active site of these protein structures. There are varieties strategies which based different algorithms but herein authors used genetic algorithms. Herein, Estrogen sulfotransferase (1AQU), Q251Q8 DESHY taken from Desulfitobacterium hafniense (3IPF), anti-apoptotic Bcl-xL (2O1Y) β-catenin (1JDH) have been chosen interact...

<p>Nowadays, many people were dying due to infectious coronavirus diseases (COVID-19). It belongs the betacoronavirus family and also known as SARS-CoV-2. However, COVID-19 is a new form that has some basic difference in genome which makes it more lethal infectious. In transmitted human late December 2019 infected about 20 million till date. Its composed of positive-sense single-stranded RNA, encodes for poly-protein. This poly-protein further cleaved into various components virus make...

Nowadays, many people were dying due to infectious coronavirus diseases (COVID-19). It belongs the betacoronavirus family and also known as SARS-CoV-2. However, COVID-19 is a new form that has some basic difference in genome which makes it more lethal infectious. In transmitted human late December 2019 infected about 20 million till date. Its composed of positive-sense single-stranded RNA, encodes for poly-protein. This poly-protein further cleaved into various components virus make numerous...

Abstract Background: Type 2 diabetes is the most common form of diabetes, accounting for over 90% cases. Current treatment approaches type include diet, exercise, and a variety pharmacologic agents, including insulin, biguanides, sulfonylureas, thiazolidinediones. Methods: In present scenario, researchers focused themselves on thiazolidine ring-based compounds to cure mellitus. Among peroxisome proliferator activated receptor (PPAR) family, PPAR-γ effective in curing glucose homeostasis....