A5065089642- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Parathyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Bone health and treatments
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- Hormonal and reproductive studies
- Ovarian function and disorders
- Vitamin D Research Studies
- Thyroid Disorders and Treatments
- Estrogen and related hormone effects
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Celiac Disease Research and Management
- Cancer, Hypoxia, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Ophthalmology and Eye Disorders
- Thyroid Cancer Diagnosis and Treatment
- Nutrition and Health Studies
- Oral and Maxillofacial Pathology
- Pharmacological Effects and Assays
- Bone health and osteoporosis research
- Menopause: Health Impacts and Treatments
- Sexual Differentiation and Disorders
Wroclaw Medical University
2006-2023
University of Wrocław
2008-2013
Niepubliczna Wyższa Szkoła Medyczna
2009
Academy of Medical Sciences
1995
Dolnośląskie Centrum Onkologii
1992
Heidelberg University
1986
Most research confirms that metformin therapy has a positive influence on cardiovascular risk factors (CVRF) such as dyslipidemia, insulin resistance and hyperandrogenism in polycystic ovary syndrome (PCOS). The aims of the present study were to establish other CVRF, plasma adiponectin, tumor necrosis factor-alpha (TNFalpha), interleukin-6 (IL-6) C-reactive protein (CRP) levels, obese premenopausal women with PCOS investigate effect treatment these factors.The group consisted 29 woman body...
Estradiol (E2) has antioxidant properties. The role of progestins in defense is still unknown. We have evaluated the influence E2 and plus medroxyprogesterone acetate (MPA) on serum lipid peroxide (LPO) levels, a marker free radical reactions, total status (TAS) postmenopausal women. Subjects consisted 26 women with surgical menopause, before after 4 months estrogen replacement therapy (ERT; E2), 54 natural menopause hormone (HRT; MPA). Forty premenopausal served as control group. Serum was...
Receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL), and its decoy receptor osteoprotegerin (OPG) play key roles in regulating bone turnover. The OPG/RANKL/RANK system is regulated by many hormones cytokines, among which parathormone (PTH) seems to be one the most important. Primary hyperparathyroidism (PHPT) with chronic excess PTH enhanced resorption provides an opportunity observe relationships between PTH, OPG RANKL. From a group 63 patients PHPT, 29 underwent effective...
Free radical reactions are involved in processes connected with aging. Estradiol acts as antioxidant and free scavenger, but the mechanism of this action remains unknown. has a hydroxyphenolic structure may donate hydrogen atoms to lipid peroxyradicals terminate chain reactions. There few reports concerning influence estradiol on natural enzyme activity, such superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) catalase (CAT). The aim study was estimate relationship between levels...
Background. The extrathyroid, orbital manifestation of Graves' disease (GD)—Graves' orbitopathy (GO)—presents a difficult clinical problem. immunological status GO patients is still under investigation. aim this study was to assess the serum concentration interleukin 6 (IL-6), soluble receptor (sIL-6R), and CD8+CD28− lymphocytes in evaluate if these parameters were associated with activity. Patients. Thirty-nine (29 women 10 men, aged 24–71, mean 50.18) newly diagnosed GD enrolled study....
Introduction: The aim was to assess associations among PCOS and NAFLD, the lipoprotein lipase polymorphism gene, metabolic disorders in PCOS. Material methods: In 184 women with 125 healthy, premenopausal volunteers, sex steroids, lipids, glucose, insulin, aminotransferases, free androgen index (FAI), HOMA-IR E2/T were calculated. Hepatic steatosis determined by ultrasound. Whole genomic DNA isolated from blood leucocytes. Lipoprotein polymorphisms rs268 rs328 analysed polymerase chain...
Background. Graves' orbitopathy (GO), also known as thyroid-associated ophthalmopathy, is characterized by dramatic tissue reactivity. Both inflammation and remodeling characterize the clinical course of GO. Some data has been found regarding association MMPs TIMPs in GO.Material Methods. Serum concentrations MMP-9, MMP-2, TIMP-1, TIMP-2 were determined ELISA method.Objectives. Forty-eight patients (34 females, 14 males, with median age 51.5 years) GD hyperthyroidism enrolled study. In 28...
Aim. The aim of the present study was to investigate influence endogenous estradiol and estrogen estrogen–progestin therapies on concentration in pre- postmenopausal women.Materials methods. groups consisted 26 women with surgical menopause (mean±standard deviation (SD): age 51.8±2.6 years, body mass index (BMI) 26.45±4.56 kg/m2), 54 natural (mean±SD: 50.5±3.0 BMI 25.75±4.09 kg/m2) 40 premenopausal controls 48.3±2.3 26.23±4.12 kg/m2). group received transdermally (50 μg/day) those...
Vitamin D affects both innate and adaptive immunity. Most of the effects vitamin on immunity are anti-inflammatory. In monocytes/macrophages, suppresses production inflammatory cytokines TNF-alpha, IL-1beta, IL-6, IL-8. Therefore, aim our study was to investigate relationship between 25(OH)D concentration selected cytokines-IL-6, TNF-α, IL-1β, which hemogram parameters for professional football players. We enrolled 41 Polish premier league soccer The mean age, career duration, VO2max were,...
Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Beside renal and skeletal complications, it has wide variety of nonspecific symptoms from other organs that mimic diseases delay the diagnosis. In recent decades clinical profile PHPT evolved to less symptomatic forms.The aim study was revise symptomatology in single region, facilitate early diagnosis by encouraging interdisciplinary communication among medical professionals.Data 100 patients (94 women 6 men, aged 57.1 ± 13.7...
The aim of the study was to assess self-reported cervical cancer screening rate among patients with inflammatory bowel diseases (IBD) and patient attitude towards human papilloma virus (HPV) vaccination. A self-designed survey conducted in hospitalized IBD patients. comprised demographic data, questions regarding smear test frequency vaccinations recommended for an patient. Randomly, completed a physician present determine question comprehension. In order provide test-retest reliability...
In order to assess safety of radioactive iodine administration in the treatment thyrotoxicosis, we measured concentrations matrix metalloproteinase-2 (MMP-2), its main inhibitor - TIMP-2 (tissue MMP-2), metalloproteinase-9 (MMP-9), TIMP-1, adiponectin, as well pro-inflammatory and procancerogenic thrombospondin-1 (TSP-1).The study involved 23 patients treated with radioiodine for thyrotoxicosis. Serum TSH, free T4, T3, MMP-2, MMP-9, TIMP-2, total adiponectin TSP-1 were by immunoassays just...
Free radical reactions are involved in processes connected with aging. Estradiol acts as antioxidant and free scavenger ,but the mechanism of this action remains unknown. has a hydroxyphenolic structure may donate hydrogen atoms to lipid peroxyradicals terminate chain reactions. There few reports concerning influence estradiol on natural enzyme activity ,such superoxide dismutase (SOD) ,glutathione peroxidase (GSH-Px) catalase (CAT). The aim study was estimate relationship between levels...
The authors estimated the influence of dehydroepiandrosterone (DHEA) administration, a potential antiatherogenic agent, on serum lipids, sex hormones and insulin levels in male rabbits fed an atherogenic diet. They concluded that (1) DHEA administration has unfavorable impact lipid profile; (2) diet causes resistance; (3) glucose are not related to normally with hyperlipoproteinemia; (4) slight increase estradiol concentration; (5) treatment no significant effect testosterone concentrations...