A5111944786- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Physical Activity and Health
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Intensive Care Unit Cognitive Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Acute Myocardial Infarction Research
- Smoking Behavior and Cessation
- Long-Term Effects of COVID-19
- Exercise and Physiological Responses
- Macrophage Migration Inhibitory Factor
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Heart Failure Treatment and Management
- Electronic Health Records Systems
- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Vaccine Coverage and Hesitancy
- Advanced Causal Inference Techniques
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Machine Learning in Bioinformatics
- COVID-19 Impact on Reproduction
Baylor Scott & White Health
2014-2025
Baylor Medical Center at Garland
2022-2025
Research Institute of Dallas
2024
Society of Critical Care Medicine
2021-2022
University of Alabama at Birmingham
2022
Agency for Healthcare Research and Quality
2020
Texas Health Resources Foundation
2020
Texas A&M Health Science Center
2015
Cooper Medical School of Rowan University
2015
Indiana University – Purdue University Indianapolis
2015
OBJECTIVE—To quantify the relation of fitness to mortality among men with diabetes, adjusted for BMI and within levels BMI. RESEARCH DESIGN AND METHODS—In this observational cohort study, we calculated all-cause death rates in diabetes across quartiles categories. Study participants were 2,196 (average age 49.3 years, SD 9.5) who underwent a medical examination, including maximal exercise test, during 1970 1995, follow-up 31 December 1996. RESULTS—We identified 275 deaths 32,161 person-years...
Data are not complete for all characteristics in the table; denominators
Objective— This study examined the association between cardiorespiratory fitness and C-reactive protein (CRP), with adjustment for weight within categories. Methods Results— We calculated median adjusted geometric mean CRP levels, percentages of individuals an elevated (≥2.00 mg/L), odds ratios across 5 levels 722 men. values were age, body mass index, vitamin use, statin medication aspirin presence inflammatory disease, cardiovascular diabetes, smoking habit. found inverse ( P...
Real-world evaluations have demonstrated high effectiveness of vaccines against COVID-19-associated hospitalizations (1-4) measured shortly after vaccination; longer follow-up is needed to assess durability protection. In an evaluation at 21 hospitals in 18 states, the duration mRNA vaccine (Pfizer-BioNTech or Moderna) (VE) was assessed among adults aged ≥18 years. Among 3,089 hospitalized (including 1,194 COVID-19 case-patients and 1,895 non-COVID-19 control-patients), median age 59 years,...
Abstract Background and Aims Recurrent myocardial infarction (MI) incident heart failure (HF) are major post-MI complications. Herein, contemporary risks for recurrent MI HF described. Methods A total of 6804 patients with a primary discharge diagnosis at 28 Baylor Scott & White Health hospitals (January 2015 to December 2021) were studied. Patient characteristics, treatment, outcomes, including HF, MI, all-cause death, cardiovascular rehospitalizations, assessed. Landmark approach...
Numerous cross-sectional studies have observed an inverse association between C-reactive protein (CRP) and physical activity. Exercise training trials produced conflicting results, but none of these was specifically designed to examine CRP. The objective the Inflammation (INFLAME) study whether aerobic exercise without dietary intervention can reduce CRP in individuals with elevated CRP.The a randomized controlled trial 162 sedentary men women (> or = 2.0 mg·L(-1)). Participants were into...
Importance Data on the epidemiology of mild to moderately severe COVID-19 are needed inform public health guidance. Objective To evaluate associations between 2 or 3 doses mRNA vaccine and attenuation symptoms viral RNA load across SARS-CoV-2 lineages. Design, Setting, Participants A prospective cohort study essential frontline workers in Arizona, Florida, Minnesota, Oregon, Texas, Utah with infection confirmed by reverse transcriptase–polymerase chain reaction testing lineage classified...
The American Association for the Surgery of Trauma (AAST) has developed a new grading system uniform description anatomic severity emergency general surgery (EGS) diseases, ranging from Grade I (mild) to V (severe). purpose this study was determine relationship AAST grades acute colonic diverticulitis with patient outcomes. A secondary propose an EGS quality improvement program using risk-adjusted center outcomes, similar National Surgical Quality Improvement Program and methodologies.This...
Purpose: Education on the self-management of COPD has been shown to improve patients' quality life and reduce hospital admissions. This study aimed assess feasibility a pilot, pragmatic Chronic Care (CCC) education program led by registered respiratory therapists determine CCC's impact readmissions, patient activation, health status. Patients methods: was prospective, randomized, pilot inpatients with admitted US community between August 2014 February 2016. In total, 308 patients were...
Objectives: Growing evidence supports the Awakening and Breathing Coordination, Delirium monitoring/management, Early exercise/mobility (ABCDE) bundle processes as improving a number of short- long-term clinical outcomes for patients requiring ICU care. To assess cost-effectiveness this intervention, we determined impact ABCDE adherence on inpatient 1-year mortality, quality-adjusted life-years, length stay, costs Design: We conducted 2-year, prospective, study in 12 adult ICUs six hospitals...
Electronic health records (EHRs) have been promoted as a key driver of improved patient care and outcomes an essential component learning systems. However, to date, many EHRs are not optimized support delivery quality safety initiatives, particularly in Intensive Care Units (ICUs). Delirium is common severe problem for ICU patients that may be prevented or mitigated through the use evidence-based processes (daily awakening breathing trials, formal delirium screening, early...
Objective To examine the association between fitness, BMI, and neutrophil, lymphocyte, monocyte, basophil, eosinophil concentrations in apparently healthy, non-smoking men. Design Cross-sectional study of 452 men from Aerobics Center Longitudinal Study examining resting concentration white blood cell subfractions across fitness (maximal METs during a treadmill exercise test) fatness (BMI) categories after adjusting for age. Results Fitness was inversely associated with all WBC subfraction...
Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% vaccinated), VE 96% (95% confidence interval [CI], 93%-98%) patients with no chronic medical conditions 83% CI, 76%-88%) ≥ 3 categories of conditions. similar between those aged 18-64 years versus ≥65 (P > .05). severe very high...
Abstract Background: Most treatments deemed effective for Helicobacter pylori eradication in developed countries are less developing countries. Regimens containing clarithromycin, metronidazole, and amoxicillin seem efficacious despite antibiotic resistance, may be a viable option Materials Methods: We evaluated the efficacy of 14‐day regimen with 500 mg clarithromycin b.i.d., metronidazole t.i.d., t.i.d. (with without proton pump inhibitor), 10‐day 1 g 20 omeprazole b.i.d. Pasto, Colombia,...
The third paper in a series on how learning health systems can use routinely collected electronic data (EHD) to advance knowledge and support continuous learning, this review describes analytical methods for individual-level EHD, including regression approaches, interrupted time (ITS) analyses, instrumental variables, propensity score methods, also be used address the question of whether intervention “works.”The two major potential sources bias non-experimental studies care interventions are...
Purpose: To test the association between repeated clinical smoking cessation support and long-term cessation. Design: Retrospective, observational cohort study using structured free-text data from electronic health records. Setting: Six diverse systems in United States. Participants: Patients aged ≥18 years who were smokers 2007 had ≥1 primary care visit each of following 4 (N = 33 691). Measures: Primary exposure was a composite categorical variable (comprised documentation medication,...