A5069237819- Cancer-related cognitive impairment studies
- Gene expression and cancer classification
- Genetics, Bioinformatics, and Biomedical Research
- Machine Learning in Bioinformatics
- Acute Lymphoblastic Leukemia research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Brain Metastases and Treatment
- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
Misr International University
2021-2024
Microglial activation underpins the methotrexate (MTX)-induced neurotoxicity; however, precise mechanism remains unclear. This study appraised potential impact of apigenin (Api), a neuroprotective flavonoid, in MTX-induced neurotoxicity rats terms microglial through targeting miR-15a/Rho-associated protein kinase-1 (ROCK-1)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway. Male Sprague Dawley were randomly divided into 4 groups: Normal control (saline i.p. daily and i.v. on days 8...
Methotrexate (MTX) is a widely used neurotoxic drug with broad antineoplastic and immunosuppressant spectra. However, the exact molecular mechanisms by which MTX inhibits hippocampal neurogenesis are yet unclear. Dexmedetomidine (Dex), an α2-adrenergic receptor agonist, has recently shown neuroprotective effects; however, its full mechanism unexplored. This study investigated potential of Dex to mitigate MTX-induced neurotoxicity memory impairment in rats possible role...
One advantage of exploring the human DNA (De-oxyribonucleic acid) is revelation its contribution to many diseases. In result DNA, there were specific genes in chromosomes that reveal Alzheimer's Disease (AD). Prognosis AD helps slowing down progression disease considerably which our main goal. an irreversible progressive brain slowly causes decline memory affecting patient's life. can be detected by screening WGS (Whole Genome Sequence) search are responsible for detecting or finding...