A5039823028- Psychedelics and Drug Studies
- Biochemical Analysis and Sensing Techniques
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Chemical synthesis and alkaloids
- Tryptophan and brain disorders
- COVID-19 and Mental Health
- Forensic Toxicology and Drug Analysis
- Posttraumatic Stress Disorder Research
- Neural and Behavioral Psychology Studies
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Complementary and Alternative Medicine Studies
Universidade de São Paulo
2018-2023
Clinics Hospital of Ribeirão Preto
2021-2023
Instituto de Neurociências e Comportamento
2018
Universidade de Ribeirão Preto
2018
Abstract Background Ayahuasca is a classic hallucinogen with anxiolytic and antidepressive properties. Anecdotal evidence also suggests that it improves performance (eg, singing, speech). This controlled trial assessed the effects of ayahuasca on speech anxiety in individuals social disorder. Methods Seventeen volunteers disorder participated pilot, proof-of-concept, randomized, parallel-group trial. Self-perception during public-speaking test was Self-statements During Public Speaking Scale...
Abstract Background The recognition of emotions in facial expressions (REFE) is a core aspect social cognition. Previous studies with the serotonergic hallucinogens lysergic acid diethylamide and psilocybin showed that these drugs reduced negative (fear) faces healthy volunteers. This trial assessed acute prolonged effects single dose ayahuasca on REFE. Methods Twenty-two volunteers participated pilot, proof-of-concept, randomized trial. Study variables included REFE task performed before 4...
Rationale: Previous studies with the serotonergic hallucinogens LSD and psilocybin showed that these drugs induced changes in personality traits, such as increases Openness. However, results are inconsistent, effects of ayahuasca on were never investigated a controlled trial. Objectives: To assess two randomized, placebo-controlled trials healthy volunteers. Methods: Data from parallel-group, volunteers included. In first trial, 15 ingested or placebo, while second trial received...
Background: One of the main public health strategies adopted at beginning COVID-19 pandemic consisted implementing strict lockdowns to stop transmission virus. Despite being an effective measure, confinement and associated social isolation create a stressful, potentially lengthy situations that has been proven have several psychological consequences. Given potential benefits certain psychedelic drugs shown for treatment disorders, this study aimed assess impact lifetime drug use on mental in...
Abstract Objective To assess endocannabinoid (anandamide, AEA; 2‐arachidonoylglycerol, 2‐AG) plasma levels in healthy volunteers and with social anxiety disorder (SAD) after a single oral dose of ayahuasca or placebo. Methods Post hoc analysis (baseline, 90 240 min drug intake) from two parallel‐group, randomized, placebo‐controlled trials. In Study 1, 20 ingested (average 1.58 mg/ml dimethyltryptamine (DMT)) placebo, 2, 17 SAD received 0.680 DMT) Results A significant difference was...
Abstract Background Serotonergic hallucinogens and cannabinoids may alter the recognition of emotions in facial expressions (REFE). Cannabidiol (CBD) attenuates psychoactive effects cannabinoid-1 agonist tetrahydrocannabinol. Ayahuasca is a dimethyltryptamine-containing hallucinogenic decoction. It unknown if CBD moderate attenuate ayahuasca on REFE. Procedures Seventeen healthy volunteers participated 1-week preliminary parallel-arm, randomized controlled trial for 18 months. Volunteers...
Rocha, Juliana Mendes MSc; Rossi, Giordano Novak Osório, Flávia L. PhD; Hallak, Jaime E. Cecílio dos Santos, Rafael Guimarães PhD Author Information
The COVID-19 pandemic has had a devastating impact on the health and wellbeing of global population. This paper presents results longitudinal transcultural study that was begun at peak (in April, 2020). An online survey used to collect data from English-, Spanish-, Portuguese-speaking participants. collected information about sociodemographics, lifestyle activities, COVID-19-related circumstances, drug use (with an emphasis hallucinogenic drugs), as well involving psychometric...
The COVID-19 pandemic has made evident the need to develop effective strategies cushion psychological consequences of social catastrophes. Preliminary evidence suggests that use hallucinogens is a protective factor mitigates against such stressors. However, underlying mechanisms must be further explored. This study specifically focused on potential role coping in this regard, analyzing them through an online survey completed by total 2971 subjects who were followed up with from beginning...
Alcohol is the recreational drug most frequently consumed, and its high frequency of use can lead to worsening social, psychological, domestic issues. The age group susceptible alcohol dependence 18- 24-year-old youths, demanding interventional tools target early involvement risks. Ayahuasca seems be a promising therapeutic tool since evidence suggests it presents potential for treatment depression, anxiety, substance abuse, among other disorders. This study aimed analyze subjective reports...
As the research field with psychedelic substances grows, it is expected to encompass a more extensive cohort of individuals presenting spectrum medical conditions, comorbidities, and unique physiological traits, thereby increasing likelihood potential adverse events. Furthermore, worth noting that there scarcity specialized literature regarding procedures ensure safe management clinical trials involving psychedelics. Acknowledging this, our team designed series protocols standardize care...