A5056928038- Mitochondrial Function and Pathology
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Dermatologic Treatments and Research
- Inflammasome and immune disorders
- Nanoparticle-Based Drug Delivery
- interferon and immune responses
- Micro and Nano Robotics
- Graphene and Nanomaterials Applications
- Metabolism and Genetic Disorders
- Protein Degradation and Inhibitors
- SARS-CoV-2 and COVID-19 Research
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
- Axon Guidance and Neuronal Signaling
- Click Chemistry and Applications
- Photosynthetic Processes and Mechanisms
- Cancer Cells and Metastasis
- Neuroscience and Neuropharmacology Research
- Nanoplatforms for cancer theranostics
- Microtubule and mitosis dynamics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infectious Encephalopathies and Encephalitis
Université du Québec à Trois-Rivières
2016-2024
Université du Québec à Montréal
2019-2024
Université du Québec
2024
University of Ottawa
2024
University of Calgary
2022
University of Fribourg
2012
Most cells constitutively secrete mitochondrial DNA and proteins in extracellular vesicles (EVs). While EVs are small that transfer material between cells, Mitochondria-Derived Vesicles (MDVs) carry specifically mitochondria other organelles. Mitochondrial content can enhance inflammation under pro-inflammatory conditions, though its role the absence of remains elusive. Here, we demonstrate actively prevent packaging pro-inflammatory, oxidized would act as damage-associated molecular...
Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness injuries of reindeer antler (velvet) regenerate, whereas back forms scar. Single-cell multi-omics reveal uninjured velvet fibroblasts resemble human fetal fibroblasts, express inflammatory mediators mimicking pro-fibrotic adult and rodent fibroblasts. Consequently, injury elicits site-specific immune responses: amplify myeloid infiltration maturation during repair, adopt an immunosuppressive phenotype...
Calretinin (CR) and calbindin D-28k (CB) are cytosolic EF-hand Ca2+-binding proteins function as Ca2+ buffers affecting the spatiotemporal aspects of transients possibly also sensors modulating signaling cascades. In adult hippocampal circuitry, CR CB expressed in specific principal neurons subsets interneurons. addition, is transiently within neurogenic dentate gyrus (DG) niche. expression during neurogenesis mark critical transition stages, onset differentiation for switch to adult-like...
Here, we report a non-invasive strategy for isolating cancer cells by autonomously propelled carbon nanotube (CNT) microrockets.
We report calcium phosphate (CaP) nanocapsule crowned multiwalled carbon nanotubes (CNT-GSH-G4-CaP) as a novel platform for intracellular delivery of an anticancer drug. As proof-of-concept, CNT-GSH-G4-CaP demonstrates release drug doxorubicin hydrochloride (DOX) within lysosomes from the interior cavity CNT upon pH triggered CaP dissolution. Importantly, we found that with nanolid can efficiently prevent untimely at physiological but promotes DOX increased acidic milieu observed in...
Abstract Mitochondria are essential for bioenergetic functions and various cellular processes, including differentiation immunity, their dysfunction leading to several pathologies. While these pathologies have traditionally been associated with ATP deficits, mitochondrial also leads reactive oxygen species (ROS) generation, inflammation, alterations the function of other organelles. negative impact on lysosomal activity has established, relationship between mitochondria rest endocytic...
OncoDiscover® is a novel platform for the capture of rare circulating tumor cells from cancer patients in presence PD-L1 oncotarget. It being used routinely clinic prognosis to improve overall survival patients.
Abstract Most cells constitutively secrete mitochondrial DNA and proteins in extracellular vesicles (EVs), small that allow the transfer of material between cells. While under pro-inflammatory conditions, this content can further enhance inflammation, its role absence inflammation remains elusive. Here, we demonstrate actively prevent packaging pro-inflammatory, oxidized into EVs. Importantly, distinction to be included EVs damaged excluded was dependent on their selective targeting one two...