The BIOPEP-UWM™ database of bioactive peptides (formerly BIOPEP) has recently become a popular tool in the research on peptides, especially these derived from foods and being constituents diets that prevent development chronic diseases. is continuously updated modified. addition new introduction information about existing ones (e.g., chemical codes references to other databases) progress. New opportunities include possibility annotating containing D-enantiomers amino acids, batch processing...

This review presents the potential for application of computational tools in peptide science based on a sample BIOPEP database and program as well other programs databases available via World Wide Web. The contains biologically active sequences enabling construction profiles biological activity protein fragments, calculation quantitative descriptors measures value proteins precursors bioactive peptides, prediction bonds susceptible to hydrolysis by endopeptidases chain. Other allergenic...

Abstract This work is a literature overview on angiotensin‐converting enzyme (ACE) inhibitory/antihypertensive peptides in food protein sources. The following aspects related to with the above‐mentioned bioactivity are discussed: (i) mechanism of action ACE, (ii) structural character ACE inhibitors/antihypertensive peptide sequences determined by different methods, including quantitative structure–activity relationship studies, (iii) their sources, (iv) absorption peptides, (v) vitro and...

The aim of the present study was to perform an in silico evaluation bovine meat proteins as potential precursors biologically active peptides, well determine whether such peptides can be released by selected proteolytic enzymes. sequences 19 were processed using BIOPEP database and program. profiles biological activity protein fragments determined following parameters calculated: frequency occurrence with given (A), release enzymes (A(E)), relative (W). Among examined proteins, collagen...

The objectives of the present study were two-fold: first, to detect whether salmon protein fractions possess angiotensin I-converting enzyme (ACE) inhibitory properties and proteins can release ACE peptides during a sequential in vitro hydrolysis (with commercial porcine enzymes) ex vivo digestion human gastrointestinal enzymes). Secondly, evaluate activity generated hydrolysates. A two-step model was performed simulate process. Salmon degraded more efficiently by enzymes than juices...

The novel BIOPEP-UWM Virtual database is designed as a repository of peptide sequences whose bioactivity or taste information was the result in silico predictions. It tool complementary to existing summarizing results experimental data on bioactive peptides. layout and organization new are identical those record includes following information: name; sequence function (understood about predicted target biomacromolecule); bibliographic with reference paper describing peptide; additional...

Multiple linear regression (MLR) models were constructed to explain the bitter taste of di- and tripeptides based on their chemical nature (structure). Sequences (51 51 tripeptides) derived from BIOPEP-UWM database sensory peptides amino acids. The measure bitterness was Rcaf., that is, relative 1 mM caffeine solution (Rcaf. = 1.0). variables indices describing properties a single residue forming peptide structure taken ProtScale Biological Magnetic Resonance Data Bank. MLR made for two...

Abstract Metabolic syndrome (MSyn) includes physiological, biochemical, clinical, and metabolic abnormalities, leading to an increase in health problems like obesity, dyslipidemia, cardiovascular diseases, diabetes, which contribute mortality rate. One of the main factors having a key impact on our is food we consume. Thus, scientists work towards discovery novel bioactive compounds with therapeutic potential address MSyn. According scientific reports, peptides derived from proteins exhibit...

Proteins, apart from their basic functions, may play the role of precursors peptides that regulate body functions and/or show antihypertensive, antithrombotic, antiamnestic, immunomodulating and other activities. Computer analysis 109 protein sequences, done with help a database containing sequences 1100 bioactive has been presented. Following discriminants have used: frequency occurence fragments in chain (A), potential activity (B) profile biological protein. 3781 present under...

The potential of collagens to release biopeptides was evaluated using the BIOPEP-UWM-implemented quantitative criteria including frequency fragments with a given activity by selected enzyme(s) (A

This study presents and analyzes the results of in silico, vitro, vivo tests investigating potential preventive properties a group biologically active milk colostrum proteins peptides; that is, casein, α-lactalbumin, β-lactoglobulin, lysozyme, lactoferrin, glycomacropeptide, proline-rich peptides, lactoperoxidase. Casein or its peptides lowers blood pressure, reduces tumor growth, shows anticoagulant, antimicrobial, antioxidant activity. hydrolysates decrease probability diabetes....

Bovine milk protein preparations (MPPs), namely micellar casein concentrate (MCC), serum (SPC), and MCC with ultrafiltrated buttermilk permeate (MBP), were analyzed as sources of inhibitors angiotensin-converting enzyme (i.e., ACE) dipeptidylpeptidase IV DPP-IV) well antioxidative peptides. The studies involved in silico predictions the release biopeptides from bovine proteins. Then, all MPPs subjected to simulated gastrointestinal digestion using INFOGEST protocol. Results a BIOPEP-UWM...

This paper reports that carp muscle tissue hydrolysates obtained after<italic>ex vivo</italic>digestion show the ACE inhibitory and antioxidative activities.

In silico and in vitro methods were used to analyze ACE- DPP-IV-inhibiting potential of Gouda cheese with a modified content β-casein. Firstly, the BIOPEP-UWM database was predict presence ACE DPP-IV inhibitors casein sequences. Then, following cheeses produced: decreased, increased, normative β-casein after 1 60 days ripening each (six variants total). Finally, determination ACE/DPP-IV-inhibitory activity identification peptides respective Gouda-derived water-soluble extracts carried out....

The aim of this study was to characterize the digests and peptides derived from oat kernel proteins in terms their major enzyme inhibitory activities related prevention cardiometabolic syndrome. It also entailed characteristics antioxidant bioactivity analyzed material. carried out using coupled silico vitro methods. additional goal investigate whether identified can pervade Caco-2 cells. Based on results bioinformatic analysis, it found that selected may be a potential source 107 with...

The BIOPEP-UWM database has recently become a standard tool supporting food peptidomics. website provides an access to the databases annotating following groups of compounds: proteins, bioactive peptides, allergenic proteins and their epitopes, sensory peptides amino acids, with bioactivity predicted in silico as well acids modifications. enables, e.g., finding or taste-affecting fragments protein peptide sequences, calculating quantitative parameters describing precursors simulating...